‘To screen or not’? For #CHB #congenital #heart #block Great debate #LUPUS2025 In #pregnant women with #SLE In + #Ro #SSA &/or #La #SSB mothers CHB Rx - #flourinated #steroids To ⬇️#fetal #mortality ❎no benefit ⬇️#cardiomyopathy ❎ ⬇️#pacemaker ❎ ⁦@RheumNow⁩ ??🤷‍♀️ https://t.co/xauDzfNBsC

Level up 🆙 #hydroxychloroquine #levels in #SLE When to determine adherence - too low To see if levels are supratherapeutic Who SLE Pts who have risks for #HCQ toxicity#CKD, liver dx, age, overdosing Why Safety Adherence ⁦@RheumNow⁩ #LUPUS2025 https://t.co/l8FPcqmTki

#Proteinuria that persists in #LN #lupus #nephritis even w mild proteinuria 👇 Worse outcomes Just like all CKD Take home Aim for None or minimal in #SLE <150 protein #voclosporin >> PBO (SoC) 1/2 Voclosporin had deep response at least once > PBO #LUPUS2025 @RheumNow https://t.co/CBUzyBatBh

Any ‘toll’ in #toll #like #receptors 7,8 in #SLE Cutaneous #lupus In #systemic or #cutaneous wk16 Rx PBO V #enpatoran No obvious dose response - all 3 dose >PBO Safe so far improves IFN No toll to pay! 👍 But need Ph3 data #LUPUS2025 @EricFMorand @RheumNow https://t.co/2DDztlVsUm

Systematic review and meta-analysis confirms modest efficacy of infliximab for pulmonary sarcoidosis and promising but limited evidence for adalimumab, tofacitinib and efzofitimob in specific sarcoid manifestations. https://t.co/XaqSiAVQTa https://t.co/DTGbIiPT3a

Systemic sclerosis is a vasular disorder! Microvascular dysfunction, Endotheliopathy, & reduced vascular reserve account for most findings. Good review w/ literature references in Arthritis Research & Therapy. https://t.co/ULfwBy7ECb https://t.co/QnpImUrA7q

Is Lupus Just a B Cell Disorder? https://t.co/0kwxE6KLeI https://t.co/pORHkg9HY6

Moving Targets in Lupus and Lupus Trials In the 1990s, lupus treatment development became a major focus, but progress was slow. Belimumab was eventually approved by recognizing that trials could only show small differences from placebo, requiring 867 patients globally to https://t.co/xrj8r1iNxr

If vagus nerve stimulation improves RA; then what if vagotomy? Danish study of vagotomy (1977-1995). 6070 vagotomy matched w/ 60,699 comparators. Truncal vagotomy was assoc w/ signif incr RA incidence (OR 2.62), but not superselective vagotomy (OR 1.05). NO diff in incident OA https://t.co/Rs1EyrQd57

Neutrophil alkaline phosphatase (NAP) elevated in active AOSD. 141 AOSD compared to Bcell lymphoma, SLE, aPL & controls. NAP pos. correl w/ Systemic Dz activity score (R=0.71), & 0.59 for CRP/ANC/ferritin. NAP scores higher in pre-MAS, but lower w/ MAS (w/lower WBC). NAP responds https://t.co/YbYPaJUEbz