Tweets
After TNFi secondary failure: does MOA switch beat TNFi cycling? UK RWD (n=155): yes for #PsA (76% vs 57% drug survival at 12m) and axSpA (80% vs 68%), but not RA. Yet 74% of axSpA pts still got another TNFi. Evidence vs practice gap in plain sight. @RheumNow #EULAR2026 POS0776
Jiha Lee @JihaRheum ( View Tweet )
2 weeks 3 days ago
JAKi vs ABA in RA-ILD: emulated target trial (n=1,162), JAKi with worse composite respiratory outcomes (HR 1.57) and all-cause mortality (HR 1.59) vs ABA over 5 yrs. JAKi with ↑ pneumonia risk. In RA-ILD, ABA may be the preferred choice? @RheumNow #EULAR2026 POS0813 #EULARBEST
Jiha Lee @JihaRheum ( View Tweet )
2 weeks 3 days ago
Real-world bimekizumab in SpA/#PsA (BIMPACT, n=223): 76% retention at 12mo, even with 54% having prior IL-17i exposure. Effective after IL-17Ai failure. Oral candidiasis higher in PsA (16.5%) vs SpA (3.3%); led to discontinuation in ~25%. @RheumNow #EULAR2026 POS0798/POS0810
Jiha Lee @JihaRheum ( View Tweet )
2 weeks 3 days ago
What defines MRI indicative of axSpA?
This systematic lit review show adapting more stringent cutoffs in BME (>=4 SIJ quads, erosion >=3 quads, fat >=5 SIJ quads) & combined BME + structural lesions inc specificity.
Time for updated definitions?
AbsPOS0866 @RheumNow #EULAR2026 https://t.co/gkVbcOAiD3
sheila @RHEUMarampa ( View Tweet )
2 weeks 3 days ago
ClearMEMory: Ph2 RCT evaluating memantine for tx of cognitive impairment in SLE using RBANS as outcome measure
MEM grp had sig. higher change in RBANS TIScore upto wk 12 vs. PBO, esp. immediate memory index score
Potential adjunct tx for NPSLE?
AbsPOS0701 @RheumNow #EULAR2026 https://t.co/UffdVPRu6s
sheila @RHEUMarampa ( View Tweet )
2 weeks 3 days ago
@RheumNow WIN Nutrition session #EULAR2026 (4)
🌾 Gluten does NOT influence biologic response in RD, BELIEVE cohort, 197 pts. No need to go gluten-free unless celiac disease
🌱 Plants for Joints trial: plant-based diet + exercise → sustained DAS28&WOMAC improvement @ 2Y, RA/OA
@RheumNow
Nelly ZIADE 🍀 @Nellziade ( View Tweet )
2 weeks 3 days ago
@RheumNow WIN Nutrition session at #EULAR2026 (3)
6.🍟 High UPF intake → increased RA risk (HR 1.06/SD), partly mediated by CRP. Not all NOVA-4 foods are equal
7.💊 Vit D supplementation significantly reduces SLE disease activity — MA of 10 RCTs, SMD −0.54 (p<0.00001).
@RheumNow
Nelly ZIADE 🍀 @Nellziade ( View Tweet )
2 weeks 3 days ago
WIN Nutrition session at #EULAR2026 (2)
🐟 n-3 PUFAs reduce RA risk by 9–10% per SD increase — especially in genetically high-risk individuals.
🫒 Mediterranean diet reduces RA risk by 25% (HR 0.75) & SLE risk by 39% (HR 0.61) in UK Biobank studies.
@RheumNow
Nelly ZIADE 🍀 @Nellziade ( View Tweet )
2 weeks 3 days ago
WIN Nutrition session at #EULAR2026 (1)
🫐Higher fruit intake → RR 0.88 & cereal intake → RR 0.87 for RA onset
🥩 Highest quartile of red & processed meat intake → nearly DOUBLE the risk of RA onset (OR 1.92, CI 1.11–3.35)
@rheumnow https://t.co/RhO08FXtLI
Nelly ZIADE 🍀 @Nellziade ( View Tweet )
2 weeks 3 days ago
COMPARE Ph I trial CD19 CAR T-cell ACPA+ refractory RA
6 pts median 6.5 b/tsDMARDs
Single CAR T infusion after lymphodepletion
Safety
-CRS only grade 1–2 (no severe events)
-No ICANS
-Transient neutropenia
-No unexpected toxicities
Efficacy
DAS28-CRP ↓ ~41% median
50% achieved https://t.co/cdEfGKcJUp
Aurelie Najm @AurelieRheumo ( View Tweet )
2 weeks 3 days ago
D2T RA shows a linked brain–psychology–immune signature
Cohort D2T RA vs non-D2T RA vs HC
91% D2T RA
Higher catastrophizing
Higher pain sensitivity
More emotion-focused coping strategies
“Chronic pain-like” profile
Associated with higher CNS related gene expression NRG1 https://t.co/nkQco73vqI
Aurelie Najm @AurelieRheumo ( View Tweet )
2 weeks 3 days ago
Oral GLP1s now coming to the market-Peptide based (can be given only on empty stomach),
Non peptide based (can be given anytime). Know about s/e and contraindications.
May have Rheumatic diseases indications soon. Imp for rheumatologists to be familiar.
#EULAR2026 @RheumNow https://t.co/KNudYN29PT
Links:
Bella Mehta @bella_mehta ( View Tweet )
2 weeks 3 days ago
