Tweets
#Urinary #biomarkers #lupus #nephritis
#Tenascin C -suggests repair, fibrosis, progress of #LN
#IL16, #CD163, & more for LN activity
Sometime a biomarker may replace repeat #kidney #biopsies?
#AMP group #Accelerated #Medicines #Program
#ACR24 @ACRheum @RheumNow abst#851
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
What to use in future for active #Sjogren's #SjD
B cell depletion, signal attenuation
Ianalumab 2+ phase3 RCTs
Telitacept +RCT
Nipocalimab FcRn +Ph2
Dazodalibep CD40L +Ph2
+RCTs
HCQ+Lef
Rituximab
?BTKi
#ACR25 @ACRheum @RheumNow
abst#LB24, LB11
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
#MTX is NOT the same as TCZ in #GCA in RCT
#TCZ did better
So use an advanced Rx for GCA
ex TCZ, Upa when approved
METOGiA RCT - more relapses in MTX
abst#891 #ACR25 @ACRheum @RheumNow https://t.co/wsEKGF8dW2
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
Will #PAD4 levels predict pts w #CCP positive #arthralgia who will develop #RA?
Leeds study - 79 at risk pts
PAD4 levels may predicting #rheumatoid #arthritis development
#ACR25 @RheumNow @ACRheum abst#832 https://t.co/dnAA6z3NJQ
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
#GCA & #PMR @ACRheum #ACR25
#gamechangers #ACRBest
Yr 2 Select-GCA abst#776
#upadacitinib in yr2 of GCA REDUCES flares
HELPFUL info ?ability to get drug for 2 yrs hopefully
Failed Phase3 RCT of #secukinumab in #GCA helped #PMR abst#1175 &
+Ph3 for PMR REPLENISH RCT
@RheumNow https://t.co/5lH6HXhnfg
Links:
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
What happens if you have #axSpA & concomitant #FM?
Pts with both have less TNFi retention,
-residual pain may lead to d/c Rx.
Need to determine if axSpA pt has #fibromyalgia as there may not be objective findings if no peripheral arthritis in axSpA.
#ACR25 @RheumNow abst#534
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
Post-CAR-T myelopathy has been an issue in heme onc, and is still an unpredictable quantity without a clear cause. Will this be a problem for autoimmune CAR-T as we gain more experience? @CarolineDiorio @ChildrensPhila in the #ACR25 BCRC pre-meeting @RheumNow https://t.co/RhhdOiyEAX
Links:
David Liew @drdavidliew ( View Tweet )
2 months 2 weeks ago
When should you order a renal bx in suspected #LN?
Active urinary sediment
Used to be #UPCR 500g/g or more
Abst#772 looked at UPCR 250g/g to 499
71% + LN and half needed Rx
esp if
Low C3,C4
Black race
Petri, Baltimore #lupus #cohort
#ACR25 @ACRheum @RheumNow
Janet Pope @Janetbirdope ( View Tweet )
2 months 2 weeks ago
RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is independently selected by RheumNow and its faculty.
Dr. John Cush @RheumNow ( View Tweet )
2 months 2 weeks ago
Next Generation T-Cell Engager: The Future
Dr. Alfred Kim reviews abstract 0001 presented at #ACR25.
https://t.co/vmZYfmKCm8 https://t.co/PkLOs9lZ8l
Links:
Dr. John Cush @RheumNow ( View Tweet )
2 months 2 weeks ago
RheumNow’s expanded coverage of the #ACR25 meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is selected by RheumNow and its faculty.
Dr. John Cush @RheumNow ( View Tweet )
2 months 2 weeks ago
CAR-T Cell Therapies Show Promise for Autoimmune Disease
Two pioneering studies presented at #ACR25 spotlight the potential of CAR-T cell therapies to transform treatment for SLE and other autoimmune diseases. These early findings suggest a new frontier in immune modulation and https://t.co/KdNWmVc4Qc
Dr. John Cush @RheumNow ( View Tweet )
2 months 2 weeks ago
