Combined 4 tofacitinib RCTs (4404 pts) found baseline probable major depression or anxiety disorder in 44.5%, 39.8%, 45.4%, 39.1% on TOFA 5 BID, TOFA 10 BID, adalimumab, & placebo. Effective RA Rx w/ Tofa or ADA lead to improved depression and anxiety https://t.co/y6UoFXANo7 https://t.co/aV5uV9qWbz

#PsA Metanalysis of 54 RCTs (22621 pts; 49% male). Males had less severe Dz than females (TJC, HAQ, global, pain) but higher PASI & CRP. Males had higher ACR20 resp to inhib of IL-17 (OR 1.7), IL-23 (1·46), 12/23 (2·67), TNF (1·55) but no diff w/ JAK/Tyk2 https://t.co/fOl9zpCv1G https://t.co/JXAj5sG1bf

Substudy of the ADVOCATE trial looked at 214 ANCA assoc vasculitis pts treated with #RTX; avacopan Rx showed improved recovery of renal function, faster reduction in albuminuria and lower glucocorticoid toxicity compared to a prednisone taper. https://t.co/ujynO9oAj0 https://t.co/JWBrKzGux1

MSK disorders affects >1.63 billion worldwide. Global Burden of Diseases study estimates that by 2050, 1.06 billion will have "other" MSK Dz (excluding RA, OA, LBP, gout, neck pain) - up from 494 million in 2020. https://t.co/cCf8biqjx1 https://t.co/Xv9qlvQl90

International study of 600 lupus pts - photosensitivity seen in 65% & was associated other lupus skin Dz (OR = 3.8). Fatigue was the most frequently reported systemic manifestation (82%). https://t.co/kjuvRZnB13 https://t.co/UTMNgiXbZZ

Can We Prevent RA? Results from the APIPPRA Trial Dr. Jonathan Kay talks with Dr. Andrew Cope about abstract 0835 at the 2023 ACR Convergence meeting in San Diego, CA https://t.co/d4nXIQbvEC https://t.co/n9kvz8Z8tY

Long term F/U of early RA, T2T RCTs (n 1616) finds excess mortality > 10yrs for BeST (SMR 1.32) & IMPROVED (SMR 1.33) RCTs; highest in ACPA+ smokers (SMR 2.80 & 2.14); Cancer main cause. SMR incr 34% & 13% for ea 1 pt incr in DAS https://t.co/mXrCnzfe4W https://t.co/wWxfI1kMbm

Simulated Trials to Counter ORAL Survelliance Dr. Jack Cush and Dr. Janet Pope at the 2023 ACR Convergence meeting in San Diego, CA. https://t.co/XF8zlISqKC https://t.co/yXn7KADIdo

Undiagnosed IBD in AxSpA Dr. Eric Dein (Summit, New Jersey) discusses Abstract #0495 presented at the ACR 2023 Convergence meeting in San Diego. https://t.co/l0pAs5u9nY https://t.co/BY5HwRlWXo

Biologics in RA: Mechanisms of Delivery Over Mechanisms of Action? Dr. Aurelie Najm discusses abstract 0838 presented at the 2023 ACR Convergence meeting in San Diego, CA. https://t.co/ffMf0R0ces https://t.co/QCAIrUmdoY

Infections During Treatment of GPA with Rituximab Dr. Richard Conway (Dublin, Ireland) discusses abstract 1584 presented at the 2023 ACR Convergence meeting in San Diego, CA. https://t.co/hBusU8XgMo https://t.co/pHT1ymQ7qR

long head of the biceps tendon is intra-articular but extrasynovial, and widely recognized as an important pain generator, especially in anterior shoulder pain. The biceps-labral complex has been identified and broken down into different regions... https://t.co/asiMiGU6hS https://t.co/PidKTSsEfG