Both Lupus Nephritis and Cutaneous lupus erythematosus (CLE) show evidence of tissue infiltrating T cells expressing hi amouts of hypoxia-inducible factor-1 (HIF-1); HIF-1 inhibition improves skin/systemic disease & decreases T cell cytotoxic activity https://t.co/Yv2K5UKjUV https://t.co/sbfLl7ZUqh

Chinese study of 5530 RA pts found 546 (9.9%) who developed diabetes. DM risk was significantly lower w/ bDMARD (HR 0.51), MTX (HR 0.50) and HCQ (HR 0.52). TNF inhibitors were also protective (HR 0.69). https://t.co/hdkyqFXbbu https://t.co/baQORpq1HP

Prolonged irAEs? 318 pts treated with anti–PD-1 therapy for melanoma, 64% had acute irAEs (14%) grade 3-5). Chronic (>3 mos) irAEs, seen in 46% (half >=grade 2, 68% had Sxs). Most commonchronic irAEs= hypothyroid (70%), arthritis (33%), dermatitis (17%) https://t.co/5SNeLTTPSk https://t.co/d6L5lnSwJR

IMMpulse study - 1 yr OL, phase 4 trial of risankizumab (150 mg, wk 0, 4) vs apremilast (30 mg bid) in 352 pts w/ moderate plaque psoriasis. RIZ had superior efficacy at wk 16 w/ PASI90 score of 55.9% vs 5.1% for APR. https://t.co/dSLJA9Tsmx https://t.co/AHPHdmOtM3

Assessment of Psoriatic Arthritis: A Global Perspective Drs. Antoni Chan, Nelly Ziade and Ihsane Hmamouchi discuss POS1542 presented at EULAR 2023 in Milan, Italy https://t.co/mSNhAma78C https://t.co/dhikAgIW7t

Cross-sectional study 365 RA pts showed eating half a pizza >1 time/wk (vs. ≤2 times/mo) was assoc w/ 70% less Dz activity; esp w/ more severe RA (80%) (benefit likely due to mozzarella & olive oil). YES, this was an italian study... https://t.co/6xKMIFdEWf https://t.co/UfpJO1xNe4

Metanalysis of remote Pt monitoring w/ electronic Outcome Measures (ePROMs) in #RA (4,473 pts, 7 studies) showed lower disease activity & higher remission rates in ePROM group (OR 1.65) & fewer F2F visits were needed in ePROM grp https://t.co/Va2Psx6zSc https://t.co/rdzam3ROJv

Antenatal Corticosteroids and Serious Infection in Offspring A claims data study shows that maternal use of antenatal corticosteroids may be associated with an increased risk of serious infection in the offspring's first 12 months. https://t.co/0qHgQkQvs9 https://t.co/hv1ACFQSZB

Italian JAKi study, 685 pts Rx w/ BARI (48%), TOFA (31%), UPA (14%), filgotinib (7%), had half (47%) Rx JAKi as 1st line, prior to a biologic. AE of special interest (1137 PYs FU) in 18%, including 1 CVA, 3 deaths/infx. High CV risk pts = Hi AESI(23%) https://t.co/0NN60tvokZ https://t.co/Dzc7OG9Mmv

Rheumatology Journals Rife With Faulty Conflict-of-Interest More often than not, conflict-of-interest disclosures in three major rheumatology journals didn't match records in the U.S. government's Open Payments database, researchers found. https://t.co/LKyEURZrQY https://t.co/EQLSWXB3o2

Multi-media, sponsor-generated clinical trial posters presented at major rheumatology meetings are now available in RheumNow’s newest offering: the Poster Hall. https://t.co/4WRpwh8iRa https://t.co/ZGKDqfjb7Y