Antidrug Antibodies Impair Response to Biologic Drugs Monitoring for antidrug antibodies with biologic has not been routine in rheumatology but a new study suggests that antidrug antibodies correlate with nonresponse to bDMARDs in RA patients. https://t.co/tMxZpbyJl1 https://t.co/VCUdkp8I15

Remembering Dr. Naomi F. Rothfield - As one of UConn School of Medicine’s first women faculty, legendary internationally-renowned rheumatologist Dr. had a nearly 50 year career at UConn Health retiring in 2016. She passed away on Sunday, July 2. https://t.co/D3vJzXQCnz https://t.co/YajGbGWpKf

Scary Outcomes with Systemic Sclerosis Sine Scleroderma The hallmark of SSc is scleroderma, but less than 10% of SSc patients have ssSSc. A EUSTAR database review compared the manifestations and outcomes of ssSSC to lcSSc and dcSSc. https://t.co/DMZTLKwmHv https://t.co/2bXqMt7H1z

Review of DMARDs on the immunogenicity of vaccines by Winthrop: - reduced by B cell depletion, MMF, CTX, AZA, ABA - no effect: IL-6 inhibitors & HCQ - MTX & steroids: gen suppressed by depends on dose & vaccine type https://t.co/mh8xDnwpim https://t.co/44HJjPq0BS

Multicenter open label trial of 30 refract. Behcets (BD) pts treated w/ tocilizumab (TCZ) x 6 mos; TCZ was effective in 83% (18 complete & 7 partial resp). Complete responses seen w/ uveitis 67%, CNS 60%, mucosal 42%, articular 21%; plus steroid sparing https://t.co/PfrAoQxC2F https://t.co/ocAFv0Y2kr

Metanalysis 62 RCTs & 16 LTE RCTs looks at neoplasia risk in JAKi, TNFi, MTX, PBO. Total CA rate=1.15/100PYs in RCTs. No diff in all CA between JAKi vs PBO or JAKi vs MTX (IRR 0.77); but JAKi had more CA than TNFi (1.50; 1.16, 1.94) https://t.co/uRLJdO8A2j https://t.co/brNX6ZSfqq

Pre-Clinical RA - Clinical Trial Outcomes https://t.co/EIG1eam31h https://t.co/6rYcGmgJG5

JAMA: Prophylaxis for Pneumocystis Pneumonia - indications and Rx - Immuncompromised and Immunodeficient - Pts on Hi Dose Steroids - ANCA–associated vasculitis https://t.co/GjtkgeZE8b https://t.co/1I1jjrI5s8

988 -- the new 3 digit Suicide and Crisis Lifeline (available since July 2022). You don't need to be in crisis or suicidal to call 988 and speak with a counselor. It is a free service available at all hours, day or night, for anyone who needs support. https://t.co/RfTfmHbvxJ https://t.co/JPihu6XOyu

A double-blind, sham-controlled RCT of auricular vagus nerve stimulation (VNS) showed NO meaningful improvement in 101 RA completers. @week 12, ACR20 was 25% for VNS vs 27% for sham (NS). Also NS was change in DAS28-CRP (–0.95 vs –0.66)(p 0.06) https://t.co/ZvsfB0Pjqh https://t.co/oFmbQXVbct

Full read review of "Treatments for Lupus Nephritis" from Isenberg et al - discussing: - Pathogenesis, outcomes - Conventional Rx - B cell targeting: BEL, RTX, Obintuzumab, Atacicept & more - Sequential Rx: Synviose, BEAT, BLISS-Believe - JAKi & more https://t.co/TiHyK4ffms https://t.co/dmFXbMxKsE

Full read review of clinical trials in CTD-ILD, specifically looking at: - Frequency of ILD in RA, SLE, SSc, Sjogr, PM/DM & Rx outcomes - Results w/ RTX, MMF, CYC, IL-6i, nintedinib, pirfenidone, Stem cell transplant https://t.co/HyCsrzejLU https://t.co/ejJKOtXupC