Is MTX worth anything in GCA? METOGiA: MTX 52w vs TCZ 52w for GCA MTX didn’t achieve non-inferiority to TCZ, but: - clearly it does something - continue both >1y: after MTX/TCZ therapy ended, they ended up with same relapse-free survival, cumulative GC #ACR25 ABST0891 @RheumNow https://t.co/WvvkHKIXuQ

In pooled PsA trials (n=1222), deucravacitinib reduced disease activity–linked proteomic scores in both sexes by Week 16. Proteomic profiling identified 133 unique proteins in males and 177 in females vs sex-matched healthy controls. Females showed greater enrichment in https://t.co/TTAWUtOLP0

#ACR25 Abstr#1535 This is super-cool & watch this space! Novel Bi-specific T-cell Engager using pan-gamma delta TCR instead of currently used CD3. In vitro study = complete B-cell depletion comparable to other BiTE, but with a more favorable cytokine release profile @RheumNow https://t.co/PtR5g3gCPH

Sex based differences in PsA proteomics Analyse from POETYK PSA 1 & 2 deucravacitinib RCT Large overlap but female pts specificities, Upregulation of: -JAK STAT pathway -Cytokine interaction Linked with higher disease activity in female groups Yes Correlation, but not https://t.co/VwiVOkxpoB

Open-label MTX vs. Toci in GCA in METOGiA Wk 78: 37% w/o relapse in MTX arm 46% w/o relapse in Toci arm MTX was NOT non-inferior to Toci Toci superior in 2ndary endpoints Cumulative doses GC not significantly different #ACR25 #ACRBest @RheumNow Abst 0891 https://t.co/lCaP4EdJ9C

List of GLP1 agonists approved currently..would they have effects in #OA Session title is should we gave them to everyone? #ACR25 @RheumNow https://t.co/dXwB6Jkg8C

HOPE for Pts w #fibromyalgia #FM #Transcutaneous #electrical #nerve #stimulation + #physio Is Better than #PT alone #Pragmatic #cluster #randomized #trial Answered impt question Does #TENS help Pts w #fibro Too ba noTENS sham Abst#LB03 #ACR25 #ACRBest @RheumNow @ACRheum https://t.co/fGyAugFtcN

Open label noninferiority RCT "METOGiA" in GCA TCZ improved relapse free survival (83% vs 67% MTX) & pred free remission (81% vs 61% MTX) wk 52. Ignore the weird primary endpt at week 78 Everyone also got pred; are we sure MTX works at all? @RheumNow #ACR25 #ACRBest Abstr#0891 https://t.co/i48JBnawB7

A randomized trial of app-based behavioral (acceptance and commitment) therapy (ACT) showed reduced pain interference and affective distress in axial SpA compared to standard of care. Acceptance was moderate, but impact was meaningful. Abstract 1461 @RheumNow #ACR25 https://t.co/sF5Ldtc61R

#1077 More health literacy work from our group! 995 people with inflammatory arthritis: lower health literacy linked to higher absenteeism & presenteeism Those with highest HLQ scores were mostly retired with better engagement in care @RheumNow #ACR25 Come check out our poster! https://t.co/CaqzkjMWYB

#ACR25 Abstr#1526 Finally it’s here! Consensus-based guidance on GC #steroid tapering in patients with #SLE. Included considerations before tapering, tapering schedules and monitoring during tapering. Looking forward to the uptake and hearing patients’ views @RheumNow #ACRBest https://t.co/FFl2TFhtTa