Allergic Drug-Induced Arthritis Dr. Jack Cush reviews the news and journal reports from this past week on https://t.co/iRqfkFu52z. This week we delve into some odd associations, repeat drug warnings and the consequences of antirheumatic therapies. https://t.co/lRBaXMAgz6 https://t.co/37gIHniIEi

Microbiome of Hip and Knee Osteoarthritis is not "Sterile" NGS techniques show the presence of bacterial DNA in surgical specimens of hip and knee arthritis, from patients undergoing first-time total joint arthroplasty, reports a study. https://t.co/FIUG73x21N https://t.co/kNHgKiuxHM

Peresolimab's Potential in Rheumatoid Arthritis Peresolimab is a humanized IgG1 monoclonal antibody that acts as a PD-1 agonist (stimulator). The NEJM reports that PER met its efficacy primary endpont in treating patients with active RA. https://t.co/B3tApMEWI3 https://t.co/Qi3WQkwvRd

Medevil ruler Bermudo II ("The Gouty", in Spanish: "el Gotoso") was King of León & Galicia (982 to 999). Some campaigns were a success but he lost wars & reign, presumeably from severe gout & could no longer ride horseback, & had to travel by litter https://t.co/xxzRNUY2mv https://t.co/YQRwGixd4Y

14 yr study #SLE (255 pts) & Lymphadenopathy. Causes: SLE (33.7%), lymphoma (0.8%) or TB (0.4%). LAD assoc w/ with fever (OR=3.3), pericarditis (4.1), membranous GN (3.6), leukopenia (2.6); NOT Wt loss, myocarditis, myositis. Bx needed to R/O lymphoma. https://t.co/WzCmtOVQWm https://t.co/rMEujVv9e2

82 Patients with Knee OA and Severe Obesity, showed that Bariatric Surgery and Weight Loss Before TKA significantly Reduced Complications Versus TKA Alone (without Wt loss surgery). TKA was delayed 17 (vs 4 mos) in Wt loss group.https://t.co/JR3BUqthhy https://t.co/q93AI4cpK0

In 2020, there were 619 million back pain cases Worldwide; this is expected to grown by 50% to 843 million people by 2050, due to ageing of populations. https://t.co/ruB0gfMoFm https://t.co/UATKXRVj9p

82 Patients with Knee OA and Severe Obesity, showed that Bariatric Surgery and Weight Loss Before TKA significantly Reduced Complications Versus TKA Alone (without Wt loss surgery). TKA was delayed 17 (vs 4 mos) in Wt loss group.https://t.co/JR3BUqthhy https://t.co/mUh5FfSUBR

U.S. FDA Approves RINVOQ® (upadacitinib) as a Once-Daily Pill for Moderately to Severely Active Crohn's Disease in Adults based on induction studies, U-EXCEED, U-EXCEL,& U-ENDURE maintenance study. This is 7th FDA approval for RINVOQ https://t.co/DwU7L9A58i https://t.co/zeeiciPx01

Dr. Spiera's approach to PMR treatment - prefers methylprednisolone - rapid taper over 16 weeks - consider GC sparing therapy (MTX, IL-6i) @Rheumnow #RNL2023 https://t.co/EtlDZm1RSb https://t.co/cZSYwYRKNM

IL-6 for PMR SPARE and SEMAPORE (Toci), SAPHYR (Sari) 2/2023: FDA approves sarilumab for PMR for inadequate response to corticosteroids or unable to taper off Robert Spiera @RheumNow #RNL2023 https://t.co/gpBYXhguaV https://t.co/7tU1VBUb6F

Cochrane metanalysis of antidepressant use in managing chronic pain shows they dont work, with the small exception, duloxetine - at standard dose (60 mg) it was effective, but no benefit to using a higher doses https://t.co/SReueTu4VV https://t.co/ki0snBMS3z