Tweets
How do you wean MTX?
Consider every other week dosing as options - supported by 2 randomized studies from 1995 and 1999
Option to lower weekly dosing in patients that want to take less often
Joel Kremer #RNL2023 @RheumNow https://t.co/3GMdn3lLhy
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
MTX lung disease:
Presents at 6-12 months
Baseline CXR is key to know if lung infiltrates are new
#RNL2023 @RheumNow https://t.co/Whu4O1GLA9
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
Do and don’t around MTX , Dr.Kremer approach to MTX #RNL2023 @RheumNow https://t.co/dXLQ0epsp4
Nouf Al hemmadi @NoufAhmedAlham2 ( View Tweet )
3 years 3 months ago
@Janetbirdope at #RNL2023
RA is not a disease of young
Incidence increasing in elderly population, not often offered the full range of medications due to co-morbidities, despite safety data
Higher DAS, seroneg
Co-morbidities decrease outcomes
@RheumNow
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
Myths of RA by Dr. Janet Pope
- RA development should have ACPA years before?
- there is a significant minority of early RA patients who are seronegative!
@RheumNow #RNL2023 https://t.co/pnOxTkfW0l
Robert B Chao, MD @doctorRBC ( View Tweet )
3 years 3 months ago
How much of RA risk is attributed to lifestyle?
@Janetbirdope presents Nurse's Health Study showing 35%
BMI and smoking increase risk of RA... in patients with ACPA positivity
#RNL2023 @RheumNow https://t.co/g9DIrgc7pk
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
@Janetbirdope #RNL2023
Benefit of intra-articular jt injections in early RA
Injection of 6-12 swollen joints (!) vs systemic glucocorticoids
-- FAR better ACR20 and ACR50 with less side effects
@RheumNow https://t.co/AtgCKOd8IC
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
29 pts w/PsA Sine Psoriasis: 16F/13M, mean age 45 yrs w/ PsA ~6.2 yrs. 54% had 1st-degree relatives with PsA. 66% had DIP arthritis, 39% polyarticular, 36% oligoarticular, 25% were axial. Nail findings seen in 89%, enthesitis 59%, dactylitis 62% https://t.co/MlnIzGBzn0 https://t.co/8hHE3Yv8UE
Links:
Dr. John Cush @RheumNow ( View Tweet )
3 years 3 months ago
Carol Langford #RNL2023 @RheumNow
Rx options for GPA showed by targeted to patient's disease characteristics of severe vs non-severe disease
CYC not for non-severe due to toxicity
MTX, MMF not for severe disease https://t.co/O3U29jmsHv
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
Carol Langford #RNL2023
Use of CYC + RTX:
Not routine upfront, but may be needed for escalating disease
Limited data to support initial usage
Higher risk of hypogammaglobulinemia, infection, and death
@RheumNow https://t.co/SHwV8o4xX1
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
Dr. Langford #RNL2023
When to use CYC over RTX for severe GPA induction?
- Severe disease with RTX intolerance
- Worsening disease despite RTX
- RGPN Cr > 4.0, mechanical ventilation? (these were excluded from RAVE trial)
@RheumNow https://t.co/twVJ81pgUK
Eric Dein @ericdeinmd ( View Tweet )
3 years 3 months ago
Dr. Carol Langford on GPA treatment
Duration of remission maintenance therapy?
- at least 2 years, after 2 years, maintenance appropriate in many cases
- consider RTX, and other cDMARDs (MTX, MMF, AZA)
@RheumNow #RNL2023 https://t.co/VmswcnzN5v
Robert B Chao, MD @doctorRBC ( View Tweet )
3 years 3 months ago
