Articles By Olga Petryna, MD
Canakinumab Yields Genetic and Disease Modifying Effects in TRAPS Patients
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease resulting from mutations of the TNF super family receptor 1A (TNFRSF1A) gene.
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EULAR Recommendations for the Management of ANCA-Associated Vasculitis
A EULAR task force has updated its 2009 recommendations for the management of anti-neutrophil cytoplasmic antibody associated vasculitis.
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Pregnancy Complications in Primary Sjogren's
Sjogren's syndrome is a highly prevalent disorder, affecting women ten times more frequently than men. Although the typical onset follows menopause, a minority of women may develop primary Sjogren’s syndrome (pSS) during child-bearing years.
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Tocilizumab Effective in PMR
Polymyalgia rheumatica (PMR) should be easy and responsive, but it can be a challenge and requires long-term steroid therapy. Problems often begin when steroid–induced side effects take their toll on a patient, especially in elderly adults.
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GWAS Reveals Shared Susceptibility Locus Between RA and SLE
While the phenotypes of RA and SLE are quite different, genome-wide association studies (GWAS) performed in the past have shown a genetic overlap between both.
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Secukinumab Improves Patient-Reported Outcomes in Psoriatic Arthritis (FUTURE 1)
Secukinumab (Cosentyx) has recently been approved for use in ankylosing spondylitis and psoriatic arthritis; the latter largely based on the FUTURE 2 and the just reported FUTURE 1 clinical trial. FUTURE 1 demonstrates the efficacy and safety of secukinumab, with inital weekly intravenous loading, given monthly as a subcutaneous injection.
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Could Rheumatoid Synovium Be a Nursery for ACPA Producing Plasma Cells ?
One of the hallmarks of aggressive rheumatoid arthritis (RA) is presence of antibodies against citrullinated protein antigens (ACPA).
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EUSTAR Analysis Yields Predictors of Skin Improvement in Diffuse Systemic Sclerosis
Systemic sclerosis is one of the most challenging of rheumatic diseases, often complicated by significant morbidity and leads to irreversible disability in many cases.
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Biosimilars Reviewed by Expert Panel
As the number of biosimilars in development keeps on growing, reaching nearly 700 products to date, demand for data from randomized controlled trials (RCTs) and an understanding of these new biologics is peaking the interest of many.
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ASAS: MRI Definition of Active Sacroiliitis
Increased use of MRI for diagnosis of spondyloarthritis (SpA) in the last two decades has led to earlier diagnoses and gradual incorporation of MRI into the SpA assessment toolset.
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