Hi Joel, Read your article about the history and development of MTX with great interest. I was surprised you did not mention the paper by Steinssen, Korn, and Weinstein as early as 1981-1982 about our trial of IM mtx at the University of Connecticut and the Newington VAH. I do believe this was a pivotal trail that helped to launch the use of MTX in RA. The trial was presented in poster form at ACR in 1981 with " standing room only" crowds. Thanks again for a great review. Dr. Alan Fischman