LC - this was an odd trial that I published here because JAKi are just starting to be studied in both PMR and GCA. I agree with you this is a head scratcher, because:
- of the 39 enrolled only 34 were treated
- Yes, it looks like steroids were optional in this study where they state, "oral glucocorticoids as rescue treatment in the event of high disease activity" and that "Subdeltoid glucocorticoid injections at week 1 and week 4 were permitted" (not required)
- It looks like they were testing the concept of treating "early PMR" without steroids and with baricitinib. Success was disease control (but not remission) at week 12 without oral glucocorticoids.
I dont think this is a better way to treat PMR, I do think this says JAK inhibitors may be effective and should be studied
JC
LC - this was an odd trial that I published here because JAKi are just starting to be studied in both PMR and GCA. I agree with you this is a head scratcher, because:
- of the 39 enrolled only 34 were treated
- Yes, it looks like steroids were optional in this study where they state, "oral glucocorticoids as rescue treatment in the event of high disease activity" and that "Subdeltoid glucocorticoid injections at week 1 and week 4 were permitted" (not required)
- It looks like they were testing the concept of treating "early PMR" without steroids and with baricitinib. Success was disease control (but not remission) at week 12 without oral glucocorticoids.
I dont think this is a better way to treat PMR, I do think this says JAK inhibitors may be effective and should be studied
JC