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Interesting results in a critically important area of unmet need given the high prevalence of knee OA is. More data regarding the potential efficacy and safety benefits of metformin in (post-traumatic) knee OA will emerge from an on-going study funded by the Arthritis Foundation: PIKASO: Preventing Injured Knees From osteoArthritis: Severity Outcomes https://clinicaltrials.gov/study/NCT06096259