By downloading this material, I acknowledge that it may be used only for personal use and personal education and that I will accredit RheumNow.com as the source and owner of this material. Commercial use or mass reproduction of this material without permission from RheumNow (info@rheumnow.com) is prohibited.
Loved reading this! I am pretty sure that nowadays if someone said “Pisetsky,” the first word out of their mouth is anti-DNA. I also believe the fact that anti-DNA antibodies probably arise in response to foreign DNA from infection, bacterial or viral, and this tolerance may potentially be broken in the gut. Our proposal states that tolerance to DNA could be broken by interactions between bacterial DNA and DN2 B cells in the gut, if DNASE1L3 is functionally impaired or insufficient. doi: 10.1016/j.imlet.2024.106937.