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And the threshold for accumulation of UA in subchondral bone is around 4-4.5 in DECT studies. So for holistic health outcomes we should be shooting for <=4.5 with ULT. Aggressive statin therapy doesn't work any better than this, with more toxicity and if you maintain 0.6 mg of colchicine a day you lower your risk of MACE by another 30%. There's the study to do. We have more effective tools than cardiology.