High uric acid has been shown to increased vascular rigidity; but not sure that does the same on renovascular system; hyperuricemia however seems to increased medullary uric acid deposits. The question is which is chicken which is egg?
Gout-ologists seem to feel 1/3 hyperuricemia would never end up with gout attack; but do we know high uric acid alone might not have renal consequence? Up to this time I still believe in treat to target, but then do we only "treat to the target" in "clinical" gout?
We still need more evidences or works to do!