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Canadian lupus cohort of 560 SLE pts without myositis at baseline. Over time, only 5 pts developed myositis (after mean 8.5 yrs). Incidence = 1.05 per 1000 PYs. Arthritis, Raynauds, -Sm Abs were common, but only non-Whites had increased risk of myositis. https://t.co/fzWhUADjMz
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Dr. John Cush RheumNow ( View Tweet)
44 pts of Inclusion body myositis were randomized to either PBO or sirolimus 2 mg/d. At 12 mos there were no signif differences betw groups for motor strength , but sirolimus had more SAEs (45 vs 27%); yet sirolimus had better HAQ, FVC & 6-min walk times. https://t.co/YhnRTnaGFl
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Dr. John Cush RheumNow ( View Tweet)
ProDERM Study: IVIG in Dermatomyositis--The ProDERM study show that IVIg is safe, effective and superior to placebo in patients with dermatomyositis (DM).
https://t.co/HOB8CYn9yc https://t.co/AmT3AQdawa
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Dr. John Cush RheumNow ( View Tweet)
2020 Rheumatology Year in Review
2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related.
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ProDERM Study: IVIG in Dermatomyositis
The ProDERM study design and outcomes are previewed in Medicine; and as promised the results were revealed at ACR Convergence in November 2020 showing that IVIg is safe, effective and superior to placebo i(PBO) in patients with dermatomyositis (DM).
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44 patient study of sirolimus vs placebo in patients with inclusion body myositis found no difference in the primary outcome of relative knee extension strength, nor in secondary outcomes. SAE were more common w/ sirolimus 45% vs 27% in PBO https://t.co/YhnRTnaGFl
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Dr. John Cush RheumNow ( View Tweet)
#BestACR20Tweets
RT @drdavidliew :The 'triple M' irAEs (myositis/myocarditis/MG): one of the rheumatic irAEs where autoAb are freq pos
Nice systematic review:
any autoAb+ 61% tested
MG+ 59% tested
MSA+ in 27% tested (18/67, 11 had myositis alone) https://t.co/aQHapPbjw9
Dr. John Cush RheumNow ( View Tweet)
IVIg in Dermatomyositis: Dr. Sheila Reyes ( @RHEUMarampa) reviews abstract #0995 presented at #ACR20.
https://t.co/PKYATqUh0d
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Dr. John Cush RheumNow ( View Tweet)
Watch our #ACR20 video recap titled "Treatment of Dermatomyositis Studies" with Dr Robert Chao (@doctorRBC). Dr. Chao reviews two important abstracts - #0955 and #0958 - on the treatment of dermatomyositis as presented at the 2020 ACR annual meeting.
https://t.co/1hiTZQVjlL https://t.co/CW9OGHTuJg
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Dr. John Cush RheumNow ( View Tweet)
Summary of #ACR20 part C:
- A must see talk was the avacopan story
- IVIG for myositis does work! More than just anecdotal evidence now
- DIET is key to helping improve autoimmune dz!
- low dz activity RA pts should taper off of MTX 1st when also on TNFi @jeffsparks @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
The 'triple M' irAEs (myositis/myocarditis/MG): one of the rheumatic irAEs where autoAb are freq pos
Nice systematic review:
any autoAb+ 61% tested
MG+ 59% tested
MSA+ in 27% tested (18/67, 11 had myositis alone)
@NilashaGhosh @lovetolearn27 @got_rheum #ACR20 ABST1574 @RheumNow https://t.co/utSj8yY0fd
David Liew drdavidliew ( View Tweet)
This cohort study presented by @Dr_Alex_Oldroyd shows that early cancer diagnosis after #myositis onset is associated with significantly improved survival.
Cancer screening essential in pts newly diagnosed with IIMs.
@RheumNow #ACR20 abs1057 https://t.co/qVsnTcEnWb
sheila RHEUMarampa ( View Tweet)
Poll results are in! 75% of those that responded plan to only screen for cardiac manifestations of myositis if a pt develops concerning symptoms. 20% screen for involvement annually w/ a TTE, troponin, BNP, and EKG! @RheumNow #ACR20 https://t.co/crUhFR6Hzf
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Pts are starting to ask me more about turmeric and ginger. Excellent review by Dr. Shah
1⃣Both good anti-inflammatory
2⃣Watch out in pts with bleeding/platelet disorder, menorrhagia, gallstones, PUD
3⃣Supported by trials
@RheumNow #ACR20 https://t.co/2U8zDQu64T
Robert B Chao, MD doctorRBC ( View Tweet)
Dr. Stone Rheum Pearls - B cell therapy treats APS-capillaritis... without effecting aPL titers. #ACR20 @RheumNow https://t.co/5ZJN3xBE57
Eric Dein ejdein1 ( View Tweet)
Great Thieves Market poster by my @jhrheumatology co-fellow Dr. James Son. 27 yo patient with active myositis has this imaging. Check it out for diagnosis! @RheumNow #ACR20 https://t.co/xUT6QkWNAX
Eric Dein ejdein1 ( View Tweet)
Do you obtain baseline and/or serial TTE, EKG, BNP, and TROPONIN* on follow-up visits of your patients with myositis? #ACR20 @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Do you obtain baseline and/or serial TTE, EKG, and BNP on follow-up visits of your patients with myositis? #ACR20 @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Dr Sammy Zakaria said we need close communication with cardiologist in myocarditis related to myositis. #ACR20 @RheumNow https://t.co/kTAZKWpw0S
Sole RetamozoSole ( View Tweet)
Myositis:getting to the Heart. #ACR20 Prof Chung @RheumNow https://t.co/pj9rzmRgyx
Sole RetamozoSole ( View Tweet)