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A systematic and scoping literature examined the Treat-to-target (T2T) approach to rheumatoid arthritis (RA), noting its implementation is suboptimal and finding many barriers to implementation.
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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com - leading with lupus because everyone wants to know about lupus!
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An international cohort study of patients with calcium pyrophosphate deposition (CPPD) disease, i.e., recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS) identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features.
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The inflammatory activity in the body caused by rheumatoid arthritis is linked to specific cognitive impairments, finds a small comparative study, published in the open access journal RMD Open.
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Researchers at Rush University analyzed clinic MDHAQ data and found between 36-40% of osteoarthritis and rheumatoid arthritis patients screen positive comorbid anxiety, depression, or fibromyalgia.
Dr. John Cush
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N Zealand Rheum Assn audit of 355 new seropositive pts referred, saw 65% starting DMARDs w/in 6 wks. DMARD starts were linked rurality & the # of rheumatologists. If there was 1 Rheum FTE/100,000 population, 80% were on DMARDs <=6wks https://t.co/8OvniRQt1I https://t.co/TsgegOJ9ZG
Dr. John Cush
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Calif Cohort of 19340 rheumatic pts, finds Cardiovascular events (CVE) in 1.4% & antiphospholipid syndr in 5.5%. CVE increased risk of adverse pregnancy outcomes (>50%), including Sm for Gestational age (aRRs 1.2-1.5), Premature birth (aRR 1.6) https://t.co/9lxzrOVEks https://t.co/Jcm7tH61cv
Dr. John Cush
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Systematic review: RX of macrophage activation syndr (MAS), included 57 reports, 1148 MAS pts (889 sJIA, 137 SLE). Most effective was high-dose GCs, IL-1 (83%) & IFNγ (93%) inhibitors, especially in sJIA-MAS. Also Ciclosporin, etoposide, Ruxolitinib https://t.co/4EnMOnlcYl https://t.co/PQnAZLvVwq
Dr. John Cush
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Full Read Overview of the safety of bDMARDs/tsDMARDS - contraindications, precautions, & boxed warnings for treatment of RA, PsA, SpA, JIA - safety checklist for a class of drugs you use and diseases you treat https://t.co/TIdCtJjF21 https://t.co/UE0nGbESDB
Dr. John Cush
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Medical literature review of suggests low vitamin D status is common in Rheumatic pts. & low vit D levels linked to loss of muscle strength, MSK pain, sarcopenia & falls (esp in IIM, PMR, SLE, RA, SSc) (BUT DOES REPLACING VITAMIN D FIX THESE PROBLEMS???) https://t.co/30IiKj7l4d https://t.co/ydU6FQMTi5
Dr. John Cush
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FIRST registry of 1424 #RA pts found 732 achieving HAQ-DI <0.5 & 454 w/ pain VAS <4/10. Achieiing LDA in 1st 6mos predicted by seropositivity & JAKi use. Less likely were: older, failin ≥ 2 b/tsDMARDs, hi baseline HAQ& steroid use (not comorbidities) https://t.co/7y0uMV414j https://t.co/6aLPTzf5fm
Dr. John Cush
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Earlier RA Diagnosis Leads to Lower Costs of Care
A study from the Leiden Early Arthritis Clinic shows that is RA is diagnosed within 12 weeks after symptom onset, treatment costs were lower in both autoantibody-negative and autoantibody-positive RA.
https://t.co/0vI4EWfBfA https://t.co/E5q3LpxC24
Dr. John Cush
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Digital Self Screening for Arthritis Diagnosis
A new study evaluates patient use of a mobile AI–based symptom checker for diagnoses, but demonstrated only modest accuracy when applied to a cohort of patients with joint symptoms.
https://t.co/YLkheDOrdI https://t.co/MFMEYifP3W
Dr. John Cush
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RA & OA: Nearly 40% have Anxiety, Depression or Fibromyalgia
Researchers at Rush University analyzed clinic MDHAQ data and found between 36-40% of OA and RA patients screen positive comorbid anxiety (ANX), depression (DEP), or fibromyalgia (FM).
https://t.co/ZElo9iPfA6 https://t.co/dcE0fAsp2N
Dr. John Cush
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Bad News Coronary Artery Calcium in Rheumatic Patients
In the 2024 SCCT meeting, Dr. Brittany Weber presented findings showing that incidentally discovered CAC in patients with IMID can lead to worse outcomes, even without prior ASCVD.
https://t.co/aJhf0IL1WW https://t.co/uMl89rXjBK
Dr. John Cush
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Earlier RA Diagnosis Leads to Lower Costs of Care
A study from the Leiden Early Arthritis Clinic shows that is RA is diagnosed within 12 weeks after symptom onset, treatment costs were lower in both autoantibody-negative and autoantibody-positive RA.
https://t.co/TnrpZGZ4fX https://t.co/elNQ3Pde2a
Dr. John Cush
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2001-2004 NHANES population study shows 28% report hx of erectile dysfunction (ED) & 19% w/ arthritis. Having arthritis was assoc w/ 4 fold higher ED risk; mostly in #OA (OR=1.11), RA (OR=1.03). https://t.co/L2LhEPH9DY https://t.co/yLhVmLw7nt
Dr. John Cush
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UK Natl Early Inflammatory Arthritis Audit (5/18-10/22) compared 682 persistently active vs 1026 low activity RA pts. pactiveRA were younger, more women. pactiveRA assoc. w/ Age, gender, smoking, depression, lung dz, gastric ulcers, baseline steroids https://t.co/QGuUZmSBHD https://t.co/TDlPFmTQEn
Dr. John Cush
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Potential of Radiomics to Predict TNF Therapy Outcomes in axSpA
Dr. Bella Mehta interviews Dr. Vincenzo Venerito about abstract POS0236 at Eular 2024 in Vienna, Austria.
https://t.co/ZR5pFINagR https://t.co/bEWjSXWlB0
Dr. John Cush
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Inspirations About RA-ILD
Dr. Jonathan Kay discusses abstracts POS0070, POS0043 and POS0022 presented at the Eular 2024 meeting in Vienna, Austria.
https://t.co/sKwr7yMUcX https://t.co/UBTYD5SioS
