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Lupus Worries (3-25-22)

Jack Cush, MD

Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.

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hospital,surgery

SLE Higher Risk of Postoperative Cardiac Events

Jack Cush, MD

ACR Open Rheumatology reports that systemic lupus erythematosus (SLE) patients have a higher risk of postoperative major adverse cardiac events (MACE) that can be identified by common cardiac risk measures.

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malar lupus

Poor Outcomes in Lupus Patients Not at Target

Jack Cush, MD

A prospective, longitudinal systemic lupus erythematosus (SLE) cohort study examined outcomes and showed that failure to control SLE was common and associated with poorer outcomes including organ damage, glucocorticoid exposure, poor quality of life, and increased mortality.

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renal.genes_.jpg

Iberdomide in Systemic Lupus Erythematosus

Jack Cush, MD

The NEJM reports that systemic lupus erythematosus (SLE) patients treated with iberdomide, a cereblon modulator, was effective at yielding a significant SRI-4 clinical response after 24 weeks. 

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pollution,smoke

Environmental Pollutants Ups Autoimmune Disease Risk

Jack Cush, MD

An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, connective tissue diseases (CTDs) and inflammatory bowel diseases (IBD).

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Poor Outcomes in Lupus Patients Not at Target A prospective, longitudinal SLE cohort study examined outcomes and showed that failure to control SLE was common/associated with poorer outcomes including organ damage, glucocorticoid exposure, and more. https://t.co/wQMmPgbmWF https://t.co/ROeZU56cfy

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Dr. John Cush RheumNow ( View Tweet)
Montreal General Hosp SLE cohort study of 489 SLE pts - 35% have Raynauds phenomena; RP in SLE assoc. w/ Female (OR 2.43), White (OR 1.85), CNS disease (OR 1.98), RNP Abs (OR 3.0); negatively assoc w/ hemolytic anemia & cellular casts https://t.co/dUxAAIIyya https://t.co/ttIt9pDsTh

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Dr. John Cush RheumNow ( View Tweet)
#ClinicalPearl #Lupus nephritis is often now START w 2 immune suppressive & less total dose of #prednisone & May pulse w 500 mg solumedrol x3 instead of 1g. J Merrill #RNL2022 @RheumNow https://t.co/ePKkPHWhYJ

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Janet Pope Janetbirdope ( View Tweet)

Dr. Peter Lipsky on the "Almighty ANA" "There are 45 million people out there with a +ANA. It is not a good screening tool." @RheumNow #RNL2022 https://t.co/Xtu7kUzd6K
Robert B Chao, MD doctorRBC ( View Tweet)
ANA ▶️Short lived plasma cell DNA. ▶️Long lived plasma cell ANA RNP. Peter Lipsky @rhumnow #Rnl2022 https://t.co/U7YkCBEEFJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
#ClinicalPearl Urinary biomarkers for #SLE #nephritis are still mostly too ‘dilute’ for prime time. Albumin/creative spot urine and #microalbuminuria are still v Impt @RheumNow #RNL2022 https://t.co/uEWs0saSX3

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Janet Pope Janetbirdope ( View Tweet)

Lupus heterogeneity: Anti Smith Anti RNP more common in certain ethnicity , more interferon production and aggressive disease!!! Peter Lipsky @rhumnow #Rnl2022 https://t.co/xGhafD4l8k
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
HEp-2 cell and ACR classification criteria: Peter Lipsky @rhumnow #Rnl2022 https://t.co/6o6epkjqB4
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Avoid screening with ANA, PLEASE!! Normal postive ANA Peter Lipsky @rhumnow #Rnl2022 https://t.co/GEKmhQfpfm
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Remarkable heterogeneity in results of #ANA testing using different assays #PeterLipsky on “Almighty ANA” at #RNL2022 @RheumNow https://t.co/A0y3ugBBrz
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
ANA levels fluctuate & depend on the https://t.co/rjZhNvSzE1 should we use it as an entry criterion to diagnose lupus ? #RNL2022

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madan madanpadmajan1 ( View Tweet)

ANA in otherwise healthy: Anti-DFS70 antibodies (Dense Fine Speckled, 70kDa molecular weight) are a sub-group of anti-nuclear antibodies. Peter Lipsky @rhumnow #Rnl2022 https://t.co/QH4qsdzZmu
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Q and A Positive ANA post COVID infection and vaccination? ⬇️ 1- Repeat test ( transient elevation). 2-Monitor clinical symptoms. PS, COVID infection ▶️lupus anti coagulant and catastrophic APS like syndrome. @RheumNow #Rnl2022

Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

ANA variability among different platforms and essays. Validated quantification test are needed!! Peter Lipsky @rhumnow #rnl2022 https://t.co/pyJhBkJE8P
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
RheumNow Live is Coming to Town! Have you signed up for RheumNow Live yet? We still have space available. https://t.co/FBCQRu32gO https://t.co/KoGR8An6af https://t.co/qtwPbMzqSO

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Dr. John Cush RheumNow ( View Tweet)
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