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What is JAKne? (5.6.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports, FDA actions, new side effects and changing prevalence of Gout.

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medical.marijuana

Lack of Research Stymies Uptake of Medical Marijuana for Rheumatic Pain

Creaky Joints

A new review article from CreakyJoints finds that there has been limited progress in understanding the potential of cannabis based therapies for the treatment of pain associated with rheumatic conditions in the past five years because of a lack of standardization of clinical research and barriers to conducting research due to existing federal and state regulations.

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Pre-exposure Prophylaxis for COVID-19 (4.22.22)

Jack Cush, MD

Dr. Jack Cush discusses the news and recent journal reports from last weeks RheumNow.com, and answers viewer questions from #ACA - Ask Cush Anything.

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vaccine,mRNA,Covid,vial

COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients

Jack Cush, MD

Putman et al has reported vaccine survey results from the COVID-19 Global Rheumatology Alliance (C19-GRA) in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD).

Survey data from 7005 vaccinated and unvaccinated, adult RMD respondents from 102 countries was analyzed.

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COVID,vaccinate,injection,green

Evusheld as Protective Therapy in High Risk COVID-19 Patients

Jack Cush, MD

A single dose of the monoclonal-antibody AZD7442 (combination of tixagevimab and cilgavimab) has been shown to be safe and effective as prophylaxis against COVID-19 infection in high risk individuals who tested positive for COVID-19. 

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Male vs. Female Responders (4.15.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal Reports from the past week on RheumNow.com - including fellowship COVID-19 concerns, the limits of T2T in gout and the real odds of RA remission with your first biologic. 

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From the Hopkins Lupus cohort - Just one month of Prednisone 40 mg/d yields a FOUR fold increase in avascular necrosis risk #UTSWSLE2022 https://t.co/RGP06PUIKH
Dr. John Cush RheumNow ( View Tweet)
UT Southwestern Symposia on "Future of SLE". Summary of Disparities in SLE Care/Outcomes (from Dr. Candace Feldman - Harvard). #UTSWSLE2022 https://t.co/KQb9JV7uJU
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How do we solve/address the problem of Health Disparities in Lupus and Rheumatology? Dr. Ashira D Blazer, MD @ashira_md (HSS) approach: Study Listen Educate Partner Diversity #UTSWSLE2022 https://t.co/w3DX1w0chy
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There is 1.4 million transgender persons in the US. ACP has published a guideline "Care of the Transgender Patient" addressing health disparities, certain cancers, substance abuse, mental health conditions, infections, and chronic diseases. https://t.co/AoBeOzv9YH https://t.co/jKabVELPxH

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TLR7 signaling impt to SLE as it drives type I IFN & activation of autoreactive B cells. Nature reports missense TLR7 (Y264H) variant from severe lupus induces guanosine & cGMP & causes murine lupus when introduced into mice. https://t.co/mzAWd3Pke8 https://t.co/knwa7fBLxk

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Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL

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SLE (n=2428) pts followed for 224,295 Pt-months- Osteonecrosis seen in 122 pts (6.5/1,000 PtYrs). Higher ON risk - African Americans (2x), Male (1.8x), smokers (1.5x). Higher Rates w/ high dose prednisone (not pulse or IM TCA) https://t.co/omU9Z1Z3kU https://t.co/wceGoCcUBV

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Dr. John Cush RheumNow ( View Tweet)
COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients Putman et al has reported vaccine survey results from the C19-GRA in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD). https://t.co/sqsOHGThzV https://t.co/zeZrlDeQ9Z

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Taiwan claims data shows among 2050 new SLE, 783 on HCQ. HCQ had no effect on future development of CKD over 14 yrs. Yet some rec HCQ in all lupus nephritis to reduce kidney flares, ESKD and death. https://t.co/JS0ST1W0LW https://t.co/ihQp3d5rcy

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ICYMI: SLE study from BC, Canada shows that among 3062 incident #SLE patients 96% received antimalarial (AM) Rx with only 40% adherent. Over a 6.4 yr F/U, 242 (8%) died. AM adherence was assoc w/ a 71% and 83% lower risk of death https://t.co/0uKAKJVxri https://t.co/KuvEA2pzrg

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Dr. John Cush RheumNow ( View Tweet)
SLE study from BC, Canada shows that among 3062 incident #SLE patients 96% received antimalarial (AM) Rx with only 40% adherent. Over a 6.4 yr F/U, 242 (8%) died. AM adherence was assoc w/ a 71% and 83% lower risk of death https://t.co/S9LsDaSZNx https://t.co/lFWZJTh367

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Increased Cancer Risk with Autoimmune Disorders (AID) The incidence and mortality of cancer among AID was studied in a large Chinese cohort, demonstrating that while onset time and risks vary, there is an increased risk of malignancy in AID. https://t.co/T2WkOWp0cA https://t.co/iNJioAvrIe

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Systematic lit review of 5694 CTD pts (SLE, RA, IIM, SSc) admitted to the ICU shows overall risk of mortality was 33%. ICU admits mainly for sepsis (43%), flares(40%). Mortality risk was 70% in IIM, 40% SSc, 35% SLE subgroup, 20% RA. https://t.co/ubVujkLCNy https://t.co/nnJdO36imK

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The Effect of Socioeconomic Status on Lupus Outcomes Socioeconomic status (SES) often associates with poorer outcomes in systemic lupus erythematosus (SLE) patients; and a current study suggests this is unrelated to healthcare access issues. https://t.co/J1BMlsakGN https://t.co/BNhCN89Pqv

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