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Hospitalized GPA - Higher morbidity, Mortality and Cost

d Jack Cush, MD

Rheumatology reports on a study of patients with granulomatosis with polyangiitis (GPA) showing worse outcomes and higher costs when hospitalized with GPA.

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Diabetes in OA: Pain Is Worse

d RheumNow

Among patients with knee osteoarthritis (OA), pain was greater for those with coexisting diabetes mellitus (DM), and this association was independent of obesity and radiographic severity, European researchers found. 

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Rheumatic dz pts from British Columbia; compared 185 DMARD exposed Pregnancies vs 6,064 PREG NOT exposed. HCQ, AZA, SSZ before/during PREG not assoc w/ SGA births. 1st trimester MTX incr odds for congenital anomalies (aOR 6.58; 1.15-37.75). https://t.co/Kz5819lk1q

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Dr. John Cush RheumNow ( View Tweet)

UK population study shows that being over age 65 yrs increased the odds of receiving Seasonal influenza vaccination; but was without a reduction in hospitalizations or mortality among elderly persons. Call for new strategies https://t.co/viXwS5yx7W

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Dr. John Cush RheumNow ( View Tweet)

2016 Americans spent $3.1 trillion($9,655/person) on healthcare - 17.9% of the US GDP. Included $380 billion on low back and neck pain (the highest) and $80.0 billion on osteoarthritis. https://t.co/OniyxzDnRu

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Dr. John Cush RheumNow ( View Tweet)

EHR analysis of two health systems on finds among 3,577 # RA pts; 507 smoked and 29% quit over 4.7 yrs. More likely to quit were new Care pts (aOR 1.60), and rural community health system pts (1.66); Seropositives were less likely to quit (0.57) https://t.co/gWcWoZpRVo

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Dr. John Cush RheumNow ( View Tweet)

1 year results of the ustekinumab in SLE trial encouraging. 1st 6 mos DBRPCT showed UST 62% vs PBO 33%. At wk 48 UST SRI4 responses maintained 63.3%; PBO crossovers caught up. 15% had seriour adverse events. https://t.co/XauG4JOJIj

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Dr. John Cush RheumNow ( View Tweet)

Korean National Health claims study shows there was a significant increased risk of incident #RA 6-7 weeks following respiratory viral infections (parainfluenza, coronavirus, metapneumovirus), most evident in women and elderly. https://t.co/njXTGzdj7r

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Dr. John Cush RheumNow ( View Tweet)

NEJM clinical case - 42-year-old man with cough and shortness of breath. Ex showed a saddle-nose deformity, CT showed destruction of the nasal bones with the formation of a large nasal cavity. Your Dx? https://t.co/DgLfFigntK

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Dr. John Cush RheumNow ( View Tweet)

"An appeaser is one who feeds a crocodile, hoping it will eat him last." - Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

FDA Requires Stronger Warning About Risk of Neuropsychiatric Events Associated with Asthma/Allergy Medication Singulair and Generic Montelukast. FDA review finds reports of \agitation, depression, sleeping problems, suicidal thoughts and actions. https://t.co/eJPVB3lS3s

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic Compilation podcast from last week - hear about: Undertreatment, Involving the Dermatologist, the 7th DMARD, Hypermobility syndrome & Pred in Hand OA. Listen to the compilation (81-85) on iTunes or SoundCloud https://t.co/GNwt9ohHRe

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic 85 - HOPE for Hand OA; Watch it here https://t.co/GNwt9ohHRe or listen to it on the podcaast https://t.co/xCwyYqx0sM

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Dr. John Cush RheumNow ( View Tweet)

News » RheumNow Podcast is up (3.6.20)! Reports on GCA, ANA in Liver Dz, Sleep apnea in RA, COPD causing RA, Aldolase in Still's, Venon as a vector. Watch it here>> https://t.co/znNXBkziBD or listen to the podcast on iTunes or SoundCloud >> https://t.co/fVPAoXYPgW

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Dr. John Cush RheumNow ( View Tweet)

Tocilizumab (Actemra) has been approved by the Chinese government to treat severe #coronavirus symptoms 👉🏽https://t.co/ETEQTga6GB #COVID2019 #COVID #CoronavirusOutbreak #Coronavid19 #covid19 #Covid_19 #CoronaAlert https://t.co/EoVGaYtkX4

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Dr Ai Lyn Tan DrAiLynTan ( View Tweet)
Check out the last 2 QD clinics on 7 DMARDs & counting and Kid Arthritis - on iTUNES or here >> https://t.co/4gDqvqHjnl and https://t.co/Lij5ot15gq

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Dr. John Cush RheumNow ( View Tweet)

Breast cancer pts taking Aromatase Inhibitors have higher Risk of Arthritis (13% vs 8.2%, p < 0.0001) & carpal tunnel (1.4% vs 0.8%, p 0.008). Taiwanese Claims Analysis of 2,055 women w/ breast cancer taking tamoxifen, anastrozole, letrozole, exemestane. https://t.co/K7IzqjN28M

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Dr. John Cush RheumNow ( View Tweet)

Fasting during Ramadan, 9th mo of Islamic calendar, with intermittent fasting (sunrise to sunset) shown to reduce Dz activity (compare pre/post fasting); 36 RA DAS 28 CRP decreased 4.3 to 3.5 (p < 0.001); 20 SpA pts 3.4  to 2.9 1.3 (p = 0.001). https://t.co/SI7jgXWz7w

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Dr. John Cush RheumNow ( View Tweet)

Small phase II pilot trial of Tocilizumab in JIA (n=22) associated uveitis failed to show efficacy - 34% (7/21) responded to treatment (p=0·11). https://t.co/2EoCfLcVOA

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Dr. John Cush RheumNow ( View Tweet)

"A fanatic is one who can't change his mind and won't change the subject" -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

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