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Articles By MedPage Today

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Noninflammatory Pain Persists in RA Despite Treatment

By MedPage Today
02 June 2020

Almost one-third of patients with new-onset rheumatoid arthritis (RA) reported persistent unacceptable pain after 21 months of combination therapy, according to a study by Swedish researchers.A total of 29% of patients continued to have unacceptable pain.

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Targeting the Wnt Pathway Fails in OA

By MedPage Today
28 May 2020

The Wnt pathway modulator lorecivivint failed to meet the primary endpoint in a phase IIa study for knee osteoarthritis (OA), but showed promise in certain patient subgroups, researchers reported.

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CNS

Anti-TNF and CNS Events: The Link Strengthens

By MedPage Today
20 May 2020

Patients with autoimmune diseases who were treated with tumor necrosis factor (TNF) inhibitors had an increased risk of developing inflammatory central nervous system (CNS) adverse events, a nested case-control study found.

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Kawasaki Disease

Kids' COVID-Linked Ailment Is Not Your Typical Kawasaki Disease

By MedPage Today
14 May 2020

As data continue to emerge about a multi-system inflammatory disorder in children apparently connected to COVID-19, evidence is growing that this is not your typical Kawasaki disease.

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Biologic Dose Cuts Feasible in RA

By MedPage Today
04 May 2020

Many patients with rheumatoid arthritis (RA) who achieved remission or low disease activity on biologic treatment were able to reduce the dose of their biologic, particularly if they were also on methotrexate, a retrospective study found.

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Lenabasum Encouraging in Systemic Sclerosis

By MedPage Today
30 April 2020

The oral cannabinoid receptor type 2 (CB2) agonist lenabasum showed promising results for systemic sclerosis (SSc) in a phase II study.

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COVID-19 and the Slippery Road of Cytokine Storms

By MedPage Today
21 April 2020

Early reports on the COVID-19 pandemic allude to a cytokine storm or hyper-inflammation, especially in patients who succumbed to the illness.

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Lower Risk of Diabetes with Abatacept

By MedPage Today
20 April 2020

 Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.

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Guselkumab a Hit in Phase III for PsA

By MedPage Today
13 April 2020

The monoclonal antibody guselkumab (Tremfya), which binds the interleukin (IL)-23 p19 subunit, was effective for psoriatic arthritis in two large clinical trials, providing comprehensive benefits for this heterogeneous disorder, investigators reported in The Lancet.

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Tanezumab: A Win as Last-Ditch Osteoarthritis Tx

By MedPage Today
07 April 2020

A phase III study of the nerve growth factor and monoclonal antibody tanezumab showed positive results in a refractory patient population with knee or hip osteoarthritis (OA) -- good enough that this agent may finally be approved after a long and rocky development road.

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