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Slow Lung Decline Typical in Systemic Sclerosis

30 September 2020

The interstitial lung disease that develops in a subset of patients with systemic sclerosis tends to be heterogeneous, with the majority of patients experiencing a slow pattern of decline in lung function, analysis of outcomes in the European Scleroderma Trials and Research (EUSTAR) database foun

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Novel Biologic Promising in Mid-Stage Scleroderma Trial

29 September 2020

The anti-interleukin agent romilkimab showed significant benefits on skin fibrosis among patients with systemic sclerosis in a phase II trial, researchers reported.

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DMARDs for Early Rheumatoid Arthritis Have Cardiovascular Benefits

21 September 2020

Patients with RA have up to a three-fold increased risk of mortality versus the general population, largely due to an increased incidence of premature CVD, such as atherosclerosis and heart failure.

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Capsaicin Injection Improves Knee OA Pain

15 September 2020

Highly purified synthetic trans-capsaicin (CNTX‐4975) injected directly into the joint reduced pain in chronic knee osteoarthritis (OA), data from the open-label phase III VICTORY-3 trial showed.

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ICYMI: HCQ May Help Prevent Fetal Heart Block

08 September 2020

Hydroxychloroquine (HCQ) helped reduce recurrent maternal autoantibody-mediated congenital heart block (CHB) in fetuses, an open-label study suggested.

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Older Lupus Patients Can Stop HCQ Without Increasing Flare Risk

02 September 2020

Since patients with SLE have longer life expectancies in the modern era, they may be at elevated risk for HCQ adverse events, including maculopathy and cardiomyopathy. Therefore, Peter M. Izmirly, MD, of New York University School of Medicine in New York City, and colleagues assessed whether older SLE patients could safely discontinue HCQ.

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Treatments Differ Across Centers in Systemic JIA

26 August 2020

Significant variations were seen across hospitals in the treatment of children admitted with new-onset systemic juvenile idiopathic arthritis (JIA), despite increasing evidence of the efficacy of biologics and the hazards of extended glucocorticoid exposure, a retrospective cohort study found.

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In Lupus, Older Age and Male Sex Raise Cancer Risk

25 August 2020

Among patients with systemic lupus erythematosus (SLE), cancer risks overall were associated with older age at diagnosis and male sex, and lung cancer specifically was related to smoking, analysis of data from a large multicenter cohort found.

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ACP/AAFP Guidelines on Managing Musculoskeletal Pain

17 August 2020

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended as first-line therapy in a new guideline for treating acute, non-low back pain from musculoskeletal injuries in outpatient settings.

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Cachexia Common in Lupus

12 August 2020

Cachexia is an underappreciated complication of systemic lupus erythematosus, researchers reported.

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