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Weight Loss from Anti-Obesity Medications Prevents Gout

Jack Cush, MD

A population based study looked at the effect of the weight loss drug, Orlistat, in obese individuals. Compared to those untreated, orlistat over 1 year was associated with significant weight loss and significantly lower risks of incident gout and recurrent gout flares among overweight or obese people.

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EULAR Review of Lifestyle Improvements for Rheumatic Patients

Jack Cush, MD

A EULAR taskforce has evaluated the effect of lifestyle behaviors in rheumatic and musculoskeletal diseases (RMDs) and concluded that there is moderate evidence for a small benefit for certain dietary components, but overall, high-level evidence regarding dietary exposures on outcomes in RMDs is lacking.

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Weight Loss Drugs and the Loss of Skeletal Muscle Mass

EurekAlert!

A recent commentary published in The Lancet journal highlights the critical importance of skeletal muscle mass in the context of medically induced weight loss, particularly with the widespread use o

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A Keto Diet for Autoimmune Disorders?

EurekAlert!

Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis.

Now, they have reason to believe it could be true.

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Happy Diwali (11.1.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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Mucosal Disruptions as Initiators of Rheumatoid Arthritis

Jack Cush, MD

Many have suggested that microbiome and mucosal disruptions are contributors to autoimmunity, especially rheumatoid arthritis (RA). This is partly represented in what is known as the "mucosal hypothesis" to RA. A current review article by Hollers, et al. addresses how distinct mucosal endotypes can serve as drivers or initiators of RA.

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Stop Counting Bugs (10.4.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research.

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Planned to post so much more from #ACR24; my favorite slides from today will have to suffice. From the #BCRC Dr Monica Guma’s - diet and microbiome. Dr @NamrataRheum -a reminder that we are all aging. Dr Connie Weyand’s -metabolic checkpoints in RA T cells and macrophage. https://t.co/MtsheVsUEQ

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Kristen Young kristenyoung ( View Tweet)
Where do SGLT2i have proven benefits for CVD? 👉 Diabetes w/high CV risk 👉Heart failure (all EF) 👉CKD Dr Weber @rheumnow #ACR24 https://t.co/vFYddrLP1Y

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TheDaoIndex KDAO2011 ( View Tweet)
SELECT trial noted reduction in CV death, MI and stroke in obese pts without diabetes (other benefits: reduction in waist circumference, BP, lipids) @rheumnow # ACR24 https://t.co/GPK4Vg5bOt

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TheDaoIndex KDAO2011 ( View Tweet)
#obesity causes a lot of diseases including #arthritis. How? ⬆️ IL-6 ⬆️ leptin ⬆️ TNF-a @RheumNow #ACR24 @rheumarhyme https://t.co/qeqTZUOEZy

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sheila RHEUMarampa ( View Tweet)
The Plants for Joints RA continuation made it to #ACR24! whole-food plant-based diet, exercise, sleep/stress Rx (added on to usual RA care i.e. DMARDs) Gains made during program were sustained, can't undersell lifestyle as part of the overall picture! #ACR24 ABST0530 @RheumNow https://t.co/XSLIwYitpH https://t.co/RfiTX8Z6ff

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David Liew drdavidliew ( View Tweet)
Year in review: Semaglutide reduced knee pain over 68 weeks in patients with high BMI and moderate knee #osteoarthritis pain But mechanism of knee pain improvement not yet known if due to wgt loss or other mechanisms. @Rheumnow #ACR24 @rheumarhyme @theactiverheum https://t.co/PkrcIMbgPl

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sheila RHEUMarampa ( View Tweet)
Weight Loss from Anti-Obesity Medications Prevents Gout A population based study looked at the effect of the weight loss drug, Orlistat, in obese individuals. Compared to those untreated, orlistat over 1 year was associated with significant weight loss and significantly lower… https://t.co/P1iRjtHgHV https://t.co/MoohUKGvUn
Dr. John Cush RheumNow ( View Tweet)
NHANES study of 11264 adolescents (12–17 yrs) found Hyperuricemia (≥ 5.5 mg/dL) in 33%, (51% males, 13% females) and was more prevalent with obesity and in non-Hispanic Asians https://t.co/rwUt1Cgg9b https://t.co/dFr1LeX0nC

Links:

Dr. John Cush RheumNow ( View Tweet)
EULAR Review of Lifestyle Improvements for Rheumatic Patients A EULAR taskforce evaluated lifestyle behaviors' effects on rheumatic and musculoskeletal diseases (RMDs), finding moderate evidence for minor benefits from certain dietary components. However, high-level evidence on… https://t.co/maaz8W5IUT https://t.co/QiE6Oo1MzX
Dr. John Cush RheumNow ( View Tweet)
Weight Loss Drugs and the Loss of Skeletal Muscle Mass A commentary in The Lancet emphasizes the importance of skeletal muscle mass in medically induced weight loss, especially with the use of GLP-1 receptor agonists. While these drugs are effective for obesity treatment, there… https://t.co/8AOgDUajw6 https://t.co/0vntwZSpLy
Dr. John Cush RheumNow ( View Tweet)
Survey of UK Rheumatology pts (n 876 found 55% take daily supplements costing £10 to £200 per month (most common: vit D, C, B complex, MVI Omega 3/6). 82% take Prescription, OTC, or non-prescription pain meds, 13% sleep aids. Half of NSAID pts also take OTC supplements… https://t.co/VpMG9SiE1E https://t.co/SJYUfogeVJ
Dr. John Cush RheumNow ( View Tweet)
GLP-1 Inhibitor Reduces Knee Osteoarthritis Pain Semaglutide (Wegovy) reduced pain and improved physical function in patients with obesity and knee osteoarthritis, a randomized trial showed. https://t.co/Ch5XYlq6lX

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Dr. John Cush RheumNow ( View Tweet)

University cohort study of 673 adults w/ CLE or dermatomyositis finds that 32% take herbal supplements, esp in younger & Hispanic pts. 31% of DM experienced Dz onset or flare after supplements (vs 10% in CLE). Elderberry had highest risk of exacerbation https://t.co/BZluGYzr3t https://t.co/5zJD7AwwNK

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Dr. John Cush RheumNow ( View Tweet)
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