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ACR21 Best Abstracts - Day 2
The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).
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Day 1 Report from ACR21
The first full day of Abstracts and Presentations from ACR Convergence, was full of highly engaging sessions, quality posters and unique presentations. To hear more about the best of the best, I would encourage you to look at our Day 1 Recap Video and Day 1 ACR Best Abstracts. Here are a few of my favorites from the first day.
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#volcosporin good ~lupus nephritis added to #MMF but underbelly - side effects like but ?less than #cyclosporin. #FDA update - ⬆️hypertension and nephrotoxicity, infection #ACR21 @RheumNow https://t.co/w5nLLSTlrB
Janet Pope Janetbirdope ( View Tweet)
BAFF & APRIL support B cell development, diff, survival.
ALPN-303: Antagonist of both BAFF & APRIL
💠⬇️B cell fxn & Ab production,⬇️Plasma cells
💠⬇️UProt, dsDNA, renal immune complexes (mouse model)
💠Pending human studies
https://t.co/kzVpUDuNWs
#ACR21 Abst#1429 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Are you using less #rituximab in #SLE during #COVID #ACR21 @RheumNow #Lupus hub
Janet Pope Janetbirdope ( View Tweet)
"Baseline and routine EKGS are NOT required for SLE patients just because they are on HCQ!" - Dr. HM Belmont. "The drug has been demonized due to its use in COVID patients. We don't need to hold HCQ for EMR alerts (e.g, with cipro, SSRIs, etc)." Abstr#1743 #ACR21 @rheumnow https://t.co/5Bxavo6dRg
TheDaoIndex KDAO2011 ( View Tweet)
#PJP prophylaxis debate at #lupus hub if on #prednisone + immune suppression. #SLE has ⤴️septra side effects. Don’t know right answer. NNT v NNH is unknown. I don’t use it in #SLE. @RheumNow #ACR21 8M212
Janet Pope Janetbirdope ( View Tweet)
#SLE study hub re #Lupus nephritis rocks. #Rituximab ⬇️antiDNA but then rebound ⤴️. Thus design of adding #belimumab to Rituximab=Less flares. Love the Hubs. #ACR21 @RheumNow https://t.co/MAhxJdmkWO 10.7326/M21-2078 #ACRBest https://t.co/qWPk5x1ZtM
Janet Pope Janetbirdope ( View Tweet)
#ACR21 Ab#1029 - Great poster by Dr. Guttmann, IRAD in Summit NJ:
▶️2019 EULAR/ACR SLE criteria vs to 1997 ACR & SLICC
⭐️64% SLE pts: all 3 criteria. 10% only SLICC, 3% '97 ACR, 2% EULAR/ACR
⭐️Simliar gender, racial disparities to prior criteria
@Rheumnow https://t.co/QzG78HJgw5 https://t.co/eyuYhj4Acf
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Abst#1029 @Rheumnow https://t.co/QzG78HJgw5
What is your preferred SLE classification criteria?
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Abs:#1429: ALPN-303: Dual BAFF/APRIL antagonist for SLE:
⭐️Encouraging immunomodulatory activity and efficacy in animal models. ⬇️ Plasma cells and Ig secretions in vitro & vivo
⭐️Well-tolerated in animals w/o adverse events
🔥Phase 1 study in healthy volunteers!
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
#ACR21 #Abstr1420 A study checking #COVID vaccine response in 90 #lupus pts and 20 HC:
⬇️Titres of Abs in SLE vs controls
💠Factors of poor response: On any DMARDs exc HCQ only (OR 15) and normal dsDNA
📢Important to pause DMARDs in stable SLE @RheumNow https://t.co/USovFkiCRb https://t.co/bn5CC0xRS9
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
📢#ACR21 #Abstr1421 Is #COVID19 vaccine safe and effective in #lupus? YES!! VOCOLUP study (N=1189 pts) showed:
💠~45% had a side-effect; of which 80% mild/moderate
💠Only 3% flared post💉(MSK + Fatigue); 10 required hospitalisation @RheumNow #ACRBest https://t.co/WF4aAfiX70 https://t.co/jc0HQoJymo
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Young patients with #SLE #lupus have a #multimorbidity burden similar to individuals 30years older than them.
A high #comorbidity burden is present in SLE pts of all ages compared to non-SLE.
How can we address this?
Abs#1049 #ACR21 #ACRBest @RheumNow
https://t.co/U6t8YBFUZz https://t.co/v7Fwof1gZc
Mrinalini Dey DrMiniDey ( View Tweet)
Watch: Lupus Updates: Dr. Michelle Petri
Dr. Michelle Petri offers perspective and insight into lupus related data presented Saturday at the #ACR21 annual meeting.
https://t.co/L7T2mNJVH0 https://t.co/MCQ7nJjCIY
Links:
Dr. John Cush RheumNow ( View Tweet)
Stopping/reducing hydroxychloroquine (HCQ) in SLE associated with increased flares, especially for those in low disease activity or in remission. Super helpful data to share with pts wanting to reduce/dc HCQ.
#ACR21 Abst#0959 Plenary Session II @RheumNow https://t.co/i7jPDN2sgZ
Pedro Castillo _Castillo_Pedro ( View Tweet)
Dr FCardwell et al on Health Info use in SLE pts b4 and during COVID19 using an online survey
🦋#lupus specialists & fam physicians - ⬆preferred & trusted health info sources but access to them ⬇frequent during covid19
A call to action?📢
@RheumNow #ACR21 abs0880 @rheumarhyme https://t.co/1NBEAlFvHx
sheila RHEUMarampa ( View Tweet)
Dr. Petri on COVID19 infection vs vaccination on SLE activity:
💠Infection = NO increase SLE activity
💠Infection =⬇️ cutaneous activity
💠Infection = ⬆️anti-cardiolipin IgG/M
💠Vaccination: no increase in activity NOR aCL IgG/M
https://t.co/fWbotSLS3o
#ACR21 Abst#0858 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
#ACR21 #Abstr0988 Can we predict who would develop #lupus? Data from the Nurses Health Study showed the best model by combining Genetic Risk Score + Clinical & lifestyle factors (AUC:0.72). Need more diversity as most pts were White and aged 50s @RheumNow https://t.co/4KHiZbRgUK https://t.co/QV4npith9H
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
How concerned should we be for #hydroxychloroquine retinopathy. >4000 pts prospectively followed. 1/2 w RA & 15% w #SLE. New risks Asian with pericentral pattern and overall. Length of time on use and ⬆️wt based dose per day & CKD all risks. Abst#0989 #ACR21 #ACRBest @RheumNow https://t.co/XTfdQpVC7H
Janet Pope Janetbirdope ( View Tweet)
