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Dr. Eric Yen presenting about lupus nephritis mortality in the USA (1999-2019):
- Increasing trend in LN mortality x5 yrs
- Increased odds of death for Black pts > Latinx > API > AI/AN
- Urbanization (large central metro area) independent RF + effect modifier
#ACR21 https://t.co/qf61SkCqw4
Danny Soulsby dsoulsMD ( View Tweet)
#ACR21 #Abstr0456 How can we explain cognitive impairment in #lupus? Using f- and DCE-MRI, a study showed:
💠Abnormalities in brain functional connectivity
💠Extensive Blood-Brain Barrier leakage (BBB)
BBB could be a future target @RheumNow https://t.co/KLeWfbQUQ0 https://t.co/ibNvBUWlMK
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
So what’s interesting is that type I IFNs actually tighten the BBB. Is this dysfunctional in SLE? Or does this argue that CI does not correlate with SLE disease activity perhaps? #ACR21 #ACRAmbassador https://t.co/y5x2k3NQFi
Alfred Kim alhkim ( View Tweet)
Why is lupus nephritis mortality trending up in the US, in contrast to overall SLE mortality?
Race matters
Urban location can make things worse
I'm outside looking in but hope it's not too bold to say disparities affect whether you live or die from LN
#ACR21 ABST0454 @RheumNow https://t.co/wmB9l9fFTT
David Liew drdavidliew ( View Tweet)
SLE patients with +aPL was associated with:
➡️Nephritis
➡️Discoid rash
➡️Serositis
➡️Neurologic disorder
Consider aPL and LAC status in patients w/these manifestations and whether anticoagulation/antiplatelets may be needed
#ACR21 Abst#0077 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Lichenoid cutaneous lupus erythematosus mimicking acanthosis nigricans
Regional Winner of Latin America and Caribbean
Image Competition: Rheum Dz in Patients of Color
#ACR21 @rheumnow https://t.co/4oAXIClwsm
TheDaoIndex KDAO2011 ( View Tweet)
#SLE pts have equal rates of post op CV events compared to TypeII DM pts and ⬆️ compared to matched controls. Esp driven by comorbidities. Should we add ASA post op in SLE pts with CV risks? #ACR21 #abst0128 @RheumNow https://t.co/COdbDxFgBQ
Janet Pope Janetbirdope ( View Tweet)
#ACR21 Abst#0454
Lupus nephritis mortality from 1999-2019
⭐️-27% age-standardized mortality rate in LN death, though increased trend in last 5 yrs!
▶️ Afr-American 38% of deaths, though 12% of population (RR ~4.5), ⬆️mortality with urbanization
https://t.co/fjeGXtItvD @RheumNow https://t.co/cE3t6lq8zi
Links:
Eric Dein ericdeinmd ( View Tweet)
Yikes! Higher rates of lupus nephritis deaths in last 5 years
👉8900 lupus nephritis deaths in USA studied
race/ethnicity and urbanization assc w/ LN mortality
👉highest in blacks and large central metro regions
#ACR21 #Plenary Abstr# 0454 @rheumnow https://t.co/bxQvID8jht
TheDaoIndex KDAO2011 ( View Tweet)
Nice graphic presentation of the results! Dr. Katie Liao and her group present the characteristics and disease manifestations of Ro+ #SLE patients from the Australian #lupus registry and biobank
@RheumNow #ACR21 abs0323 https://t.co/Yl5sZgiTw1
sheila RHEUMarampa ( View Tweet)
#ACR21 #Abstr0454 Mortality rate in #lupus nephritis ⬇️by 26% from 1999-2019👏. BUT, racial and residence disparities were concerning; worse in Black, Hispanic, Asian, AI/AN vs White and in large central and medium metro. Residential matters! @RheumNow https://t.co/33vN39acuL https://t.co/XMwN2hXJn7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Race/ethnicity and residence were independent risk factors for LN mortality which was higher in:
➡️Black patients
➡️Those living in central metro areas
#ACR21 Abst#0454 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
#ACR21 Abst#0456. Fxnal connectivity, ⬆️ blood-brain barrier (BBB) leakage & cognitive impairment (CI) in SLE
⭐️SLE pts ⬆️♀️, older, caucasian, ⬇️ edu than controls
⭐️CI in longer disease, APS
▶️ SLE CI:⬇️Brain-wide connections, BBB permeability
https://t.co/fen9OYhWhC @Rheumnow https://t.co/DMQfWCqUhh
Links:
Eric Dein ericdeinmd ( View Tweet)
Functional MRI eval neuro-connectivity in 78 SLE pts
Cognitive impairment occurred in 48%; pts had:
👉longer disease duration
👉likely +LAC
👉abnormal fMRI
👉>blood brain barrier permeability
#ACR21 #Plenary Abstr# 0456 @rheumnow https://t.co/WI5CD73rvM
TheDaoIndex KDAO2011 ( View Tweet)
How about lipoprotein a as a potential biomarker for poor renal outcomes in #lupus?
Results of this study by Dr @CaoilfhionnMD and her group show that ⬆Lp(a) is strongly associated w/ proteinuria, ⬇ eGFR and ⬆PGA.
Interesting🤓
@RheumNow #ACR21 abs0327 https://t.co/MLgJ1tPJMp
sheila RHEUMarampa ( View Tweet)
#ACR21
Many faces of cell death
Netosis in APS and #SLE
NETs and APS
🕸️NETs are prothrombotic🕸️ https://t.co/FG3VNbQPzh
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
Plenary I
0454 LN mortality in the US & disparities using CDC WONDER data 1999-2019
"LN mortality exhibited profound disparities by race/ethnicity and place of residence"
https://t.co/UtMzaiL14D
#ACR21 https://t.co/C3fuq8anvR
Rheum Cat rheum_cat ( View Tweet)
Dr. Petri et al showed transition between lupus anticoagulant (-) to (+), (+) to (-), and (+) or (-) to thrombosis could be estimated by multistate Markov model.
#ACR21 Abst#0076 @RheumNow https://t.co/oIvbak4lV4
Pedro Castillo _Castillo_Pedro ( View Tweet)
Machine learning predicted lupus nephritis in #SLE patients in real world data #ACR21 @RheumNow #abst0324 https://t.co/67HBT7F2GO
Bella Mehta bella_mehta ( View Tweet)
Don't wait!
DR. Petri wants us to change paradigm of how we treat aggressive lupus nephritis: early, aggressive, and multimodal. Does not matter if you add on VCS or BLMB, just don't treat LN with MMF monotherapy.
#ACR21 #GreatDebate @rheumnow https://t.co/ebSiic095h
TheDaoIndex KDAO2011 ( View Tweet)
