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Contraceptive methods available for pts, avoid estrogen in +aPL or active SLE #acr21 @acrheum reproductive guidelines @rheumnow https://t.co/dNfSyqjWKc
TheDaoIndex KDAO2011 ( View Tweet)
Remember: IUDs are the easiest contraception to recommend to SLE patients... Sammaritano lecture going on now #ACR2021 @RheumNow https://t.co/ZGRFIZyf5h
Donald Thomas, MD lupuscyclopedia ( View Tweet)
#ACR21 The Great Debate: Belimumab vs Voclosporin as Add-On Therapy in #LupusNephritis | Dr. Petri & Dr. Rovin
Audience Vote 🗳: What would you add to mycophenolate first?
Belimumab 71%, Voclosporin 29%
#ACRAmbassador @ACRheum
Summary of Pros & Cons of Each⬇️ https://t.co/OtLxs8IYr9
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
Excellent debate in #Lupus nephritis 6S214 with Wofsy, Isenberg & Costenbader. Q’s. What to do about Class V renal, many class III, IV LNdon’t go into sustained remission, cases of new onset LN in pts with #Belimumab ?more/less than expected, which drug to use @RheumNow #ACR21 https://t.co/tWbw79dE7d
Janet Pope Janetbirdope ( View Tweet)
Abs0266 #acr21 @RheumNow study of impact of pandemic on pts w/SLE (67%), RA (19%), & pSS (8%): 63%reported a flare since the pandemic & 16% had COVID-19. 19% reported no changes to their care.76% reported a change in their mood& emotional health. Was your pts experience similar?
Olga Petryna DrPetryna ( View Tweet)
In a newly diagnosed SLE patient with class IV nephritis, already on HCQ, in addition to GC's, would you... #ACR21 #GreatDebate @rheumnow #LupusNephritis
TheDaoIndex KDAO2011 ( View Tweet)
Secondary antiphospholipid syndrome (2APS) in SLE in Georgia Registry
👉12-14% of SLE pts
👉aCL 67%, LAC 51.5%, and aB2GP 7.7%
👉Inc rates of +dsDNA/Smith, livedo reticularis, serositis, & heme/renal/neuro d/o
👉⬇️rate in Black pts, but ⬆️thrombosis
#ACR21 Abs 0078 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Lupus Nephritis in pregnancy:
@HopkinsRheum Petri recommendations
⭐️AZA safe for LN, with tacro if needed
⭐️❌Voclosporin (alcohol content)
⭐️Belimumab uncertain
@Rheumnow #ACR21 Great Debate
Eric Dein ericdeinmd ( View Tweet)
Dr. Eric Yen presenting about lupus nephritis mortality in the USA (1999-2019):
- Increasing trend in LN mortality x5 yrs
- Increased odds of death for Black pts > Latinx > API > AI/AN
- Urbanization (large central metro area) independent RF + effect modifier
#ACR21 https://t.co/qf61SkCqw4
Danny Soulsby dsoulsMD ( View Tweet)
#ACR21 #Abstr0456 How can we explain cognitive impairment in #lupus? Using f- and DCE-MRI, a study showed:
💠Abnormalities in brain functional connectivity
💠Extensive Blood-Brain Barrier leakage (BBB)
BBB could be a future target @RheumNow https://t.co/KLeWfbQUQ0 https://t.co/ibNvBUWlMK
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
So what’s interesting is that type I IFNs actually tighten the BBB. Is this dysfunctional in SLE? Or does this argue that CI does not correlate with SLE disease activity perhaps? #ACR21 #ACRAmbassador https://t.co/y5x2k3NQFi
Alfred Kim alhkim ( View Tweet)
Why is lupus nephritis mortality trending up in the US, in contrast to overall SLE mortality?
Race matters
Urban location can make things worse
I'm outside looking in but hope it's not too bold to say disparities affect whether you live or die from LN
#ACR21 ABST0454 @RheumNow https://t.co/wmB9l9fFTT
David Liew drdavidliew ( View Tweet)
SLE patients with +aPL was associated with:
➡️Nephritis
➡️Discoid rash
➡️Serositis
➡️Neurologic disorder
Consider aPL and LAC status in patients w/these manifestations and whether anticoagulation/antiplatelets may be needed
#ACR21 Abst#0077 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Lichenoid cutaneous lupus erythematosus mimicking acanthosis nigricans
Regional Winner of Latin America and Caribbean
Image Competition: Rheum Dz in Patients of Color
#ACR21 @rheumnow https://t.co/4oAXIClwsm
TheDaoIndex KDAO2011 ( View Tweet)
#SLE pts have equal rates of post op CV events compared to TypeII DM pts and ⬆️ compared to matched controls. Esp driven by comorbidities. Should we add ASA post op in SLE pts with CV risks? #ACR21 #abst0128 @RheumNow https://t.co/COdbDxFgBQ
Janet Pope Janetbirdope ( View Tweet)
#ACR21 Abst#0454
Lupus nephritis mortality from 1999-2019
⭐️-27% age-standardized mortality rate in LN death, though increased trend in last 5 yrs!
▶️ Afr-American 38% of deaths, though 12% of population (RR ~4.5), ⬆️mortality with urbanization
https://t.co/fjeGXtItvD @RheumNow https://t.co/cE3t6lq8zi
Links:
Eric Dein ericdeinmd ( View Tweet)
Yikes! Higher rates of lupus nephritis deaths in last 5 years
👉8900 lupus nephritis deaths in USA studied
race/ethnicity and urbanization assc w/ LN mortality
👉highest in blacks and large central metro regions
#ACR21 #Plenary Abstr# 0454 @rheumnow https://t.co/bxQvID8jht
TheDaoIndex KDAO2011 ( View Tweet)
Nice graphic presentation of the results! Dr. Katie Liao and her group present the characteristics and disease manifestations of Ro+ #SLE patients from the Australian #lupus registry and biobank
@RheumNow #ACR21 abs0323 https://t.co/Yl5sZgiTw1
sheila RHEUMarampa ( View Tweet)
#ACR21 #Abstr0454 Mortality rate in #lupus nephritis ⬇️by 26% from 1999-2019👏. BUT, racial and residence disparities were concerning; worse in Black, Hispanic, Asian, AI/AN vs White and in large central and medium metro. Residential matters! @RheumNow https://t.co/33vN39acuL https://t.co/XMwN2hXJn7
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Race/ethnicity and residence were independent risk factors for LN mortality which was higher in:
➡️Black patients
➡️Those living in central metro areas
#ACR21 Abst#0454 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
