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Rheumatoid,RA,nodules,damage

Shifting Trends in Initial RA Treatment Approaches

d Caoilfhionn Marie Connolly, MD

A recent study by Sparks et al reveals evolving trends in DMARD usage for rheumatoid arthritis over two decades in the United States. This retrospective analysis evaluated 407,728 DMARD initiation episodes among 229,365 unique patients from 2001 to 2021.

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RA pearls from #ACR24 review course: 1. Remission is DRUG maintained-Ok to reduce MTX dose while on TNFi. 2. Multimorbidity=Poor outcomes, High risk for mortality. 3. Can RA be truly prevented or we are delaying the inevitable? https://t.co/111w1Myqrg

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Adela Castro AdelaCastro222 ( View Tweet)
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ACR24 Preview Podcast (11.15.2024)

d Jack Cush, MD

ACR 2024 starts tomorrow. Here are a few previews of abstracts to be presented, along with my recommendations of sessions you don’t want to miss.

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Multimorbidity reduces response to b/tsDMARDs in RA. We can make a difference by treating the whole person! Amazing talk by Dr Iain McInned to wrap up #ACR24 #ReviewCourse. @RheumNow https://t.co/NiaUXzt4nT

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Jiha Lee JihaRheum ( View Tweet)
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A Polygenic Model for Still's Disease

d Jack Cush, MD

Adult-onset Still's disease (AOSD) is systemic autoinflammatory disorder of unknown etiology.  It is considered among the febrile autoinflammatory etiologies.

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Survey of 779 RA pts in the National Rheumatoid Arthritis Society. Respondents were 95% Caucasian in their 50s with menopause in their 40s. 80% responded that their arthritis was worse during the menopause with 10% being much worse. https://t.co/NqZXK1lLQe https://t.co/k59HD5bKrd

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Dr. John Cush RheumNow ( View Tweet)
PAs in rheumatology report higher job satisfaction and lower burnout rates compared to PAs. Study of 430 PAs practicing in rheumatology. median age = 39 yrs, 85% female. They are 79%office-based practices, more likely to Tx older pts & engage in telemedicine(62.5%)… https://t.co/Zti5YMBo8o https://t.co/2XaWjythR1
Dr. John Cush RheumNow ( View Tweet)
Dysregulated overproduction of angiopoietin-like protein 4 (ANGPTL4) may be involved in RA pathogenesis. Markedly elevated in RA tissues & is a regulator of angiogenesis & inflammation. Anti-ANGPTL4 inhibited Dz in mice and fibroblast-like synoviocyte migration &… https://t.co/aOpnxicQSs https://t.co/1BC8CxwF6V
Dr. John Cush RheumNow ( View Tweet)
Dr. Quotes (11.8.2024) Dr. Jack Cush reviews the news and journal reports from this past week from https://t.co/V10S4oWdi3. https://t.co/NEXFg3Mp5G https://t.co/tUkGSgm6O7

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Dr. John Cush RheumNow ( View Tweet)
Dr. Quotes (11.8.2024) Dr. Jack Cush reviews the news and journal reports from this past week from https://t.co/V10S4oWdi3. https://t.co/NEXFg3Mp5G https://t.co/tUkGSgm6O7

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Dr. John Cush RheumNow ( View Tweet)
Early RA Journey - Patient Perspectives and Uncertainties Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake… https://t.co/gwNL7iZIT5 https://t.co/SL0Jw0H8f6
Dr. John Cush RheumNow ( View Tweet)
T cell study of bronchoalveolar lavage fluid, blood & synovium from 17 early RA ACPA+ pts (TCR sequencing & immunophenotyping) found shared lung/joint T cell repertoires driven by smoking. The RA TCR repertoire shaped by MHC predisposition, smoking leading to autoimmunity… https://t.co/0lEVwEbKcW https://t.co/YrhV79AvX4
Dr. John Cush RheumNow ( View Tweet)
Save the date! RheumNows will be covering #ACR24 from 11/14-11/19. Get ready for daily recaps, live streaming and much, much, more! https://t.co/vwNFU501di
Dr. John Cush RheumNow ( View Tweet)
Gut microbiome changes linked to onset of RA Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published… https://t.co/gUgYLOKrI0 https://t.co/d75NmKup2U
Dr. John Cush RheumNow ( View Tweet)
Early Rx doesnt prevent Difficult to Tx RA (D2TRA). Propective study of 722 early RA pts Rx w/ MTX found after 73 mos 29% were D2TRA. 21.5% Rx w/ b/tsDMARD after 19 mos, yet 70% were uncontrolled. 5 yr retention rates were 40%. D2T predicted by pain & swollen joints… https://t.co/veaspuCHIE https://t.co/zjlTWQn4GQ
Dr. John Cush RheumNow ( View Tweet)
undifferentiated,arthritis,early,RA

Early RA Journey - Patient Perspectives and Uncertainties

d Jack Cush, MD

Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake and referral. PCP and HCP delays in referral to a specialist still exist.

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Biosimilar Slow Growth in USA

d Jack Cush, MD

A recent Forbes article, "Biosimilars Are Making Inroads In U.S., But It’s Still A Bumpy Ride", reviews the current state and reasons for slowish uptake of these significant cost-savings alternatives to biologic therapy in treating cancer and autoimmune disorders. The following are takeaway bullets from this informative article.

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Genes Linking RA and Osteoporosis People with rheumatoid arthritis often develop osteoporosis, a more serious condition, as a result of the bone damage caused by immune cells and as a side effect of certain medications. https://t.co/hEJc77gcln https://t.co/bmsV70riUc

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Dr. John Cush RheumNow ( View Tweet)
VA #RA registry study of 263 RA-ILD pts (mean 69 yrs, 95% male, 73% W, 85% smokers), finds the MUC5B promoter variant in 33.5%. While the MUC5B variant is assoc w/ RA-ILD risk, it does not predict survival or mortality. Other genetic & nongenetic factor must be responsible… https://t.co/sr1AtAZRDT https://t.co/KKD7RLnIqR
Dr. John Cush RheumNow ( View Tweet)
New download available! Substitute Inflammatory Measures https://t.co/FiZSvvl5DA https://t.co/QwVefFLcHO

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Dr. John Cush RheumNow ( View Tweet)

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