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H2H: Ixekizumab vs. Adalimumab in Psoriatic Arthritis

d Jack Cush, MD

Lilly has issued an advanced press release on its SPIRIT-H2H trial, wherein ixekizumab (Taltz) was shown to be more effective than than adalimumab (Humira) in a 24 week psoriatic arthritis study.

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Rising Physician Exclusion from Medicare and Medicaid

d Jack Cush, MD

JAMA Network Open has published that an increasing number of physicians are being excluded from Medicare and other forms of public insurance. 

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Cryotherapy Never FDA Approved

d RheumNow

Another injury related to whole body cryotherapy (WBC) has been reported by practitioners in Philadelphia, serving as yet another warning of WBC's potential to cause serious adverse effects.

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RheumNow Podcast – Vasculitis and Strange Bedfellows (12.14.18)

d Jack Cush, MD

Dr. Jack Cush reviews the news from the past week on RheumNow.com. 

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CDC Top 15 Most Common Opioid Overdose Drugs

d Jack Cush, MD

The Dec. 12 issue of the National Vital Statistics Reports from the U.S. Centers for Disease Control and Prevention reports that the most commonly abused drugs causing drug overdose deaths (between 2011-2016) include fentanyl, heroin, oxycodone, and cocaine.

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Clinical pain severity & disability in OA is higher amongst African Americans vs Whites. Metanalysis of 61 articles shows higher pain severity in AA using the WOMAC (0.57; 95%CI: 0.54, 0.61) & non-WOMAC studies (0.35; 95%CI: 0.23, 0.47). Journal of Pain. https://t.co/qLm2Pbw7pz

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 282 Bx proven Temporal arteritis pts (Northern Italy) finds increased mortality associated with large vessel Dz (HR 5.14) at diagnosis and reduced mortality with PMR (HR 0.57) at Dx and adventitial inflammation (HR 0.31) on Bx. https://t.co/iF90cqYtqn

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Podcast is up - Vasculitis and strange bedfellows. Watch here https://t.co/SEw0RojCBB or listen on iTunes or here https://t.co/8StKrqV11F

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Dr. John Cush RheumNow ( View Tweet)

Check out Vinay Prasads @VPplenarysesh Plenary Session Podcast that discusses studies on Fish oils and MTX in cardiology - the CIRT NEJM study appears at 35:23 - interesting to hear non-Rheum views on this approach https://t.co/MQCWLYgEnD

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of 24 PPI studies, 319,568 hip fracture pts, suggests PPIs associated with a greater risk of hip fracture (RR 1.20, 95% CI 1.14–1.28, p < 0.0001) and may be greater with higher dose (RR 1.30, 95% CI 1.20–1.40, p < 0.0001). https://t.co/nbiEIPRaXg

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Dr. John Cush RheumNow ( View Tweet)

Len Calabrese says its about time Rheumatologists tap into new ways of learning - social media, the ACR Meeting App, Websites covering the meetings and journals. Time to get on the bus! https://t.co/pRdJqGv3OM

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Dr. John Cush RheumNow ( View Tweet)

Study of 1.8 million Psoriasis pts in RCTs shows a ~1.7 fold increased risk of Crohn Dz & ulcerative colitis. Study of 5. 9 millions with Pso in Cohort studies finds a 2.5-fold increased risk of Crohns and a 1.7-fold increased risk of ulcerative colitis https://t.co/3Ccl2VR8iz

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Dr. John Cush RheumNow ( View Tweet)

With irAEs arthralgias snd arthritis are common, but also can present as tendinitis tenosynovitis, dactylitis, PMR and most are seronegative https://t.co/WRvczdEsh9
Dr. John Cush RheumNow ( View Tweet)
Bing Bingham MD talking on immune related adverse events (MSK and autoimmune). Says these occur in 3-5% of cancer pts treated with Checkpoint inhibitors. Unofficial surveys show nearly 50% of Rheums have seen these referrals. #MARS #ARTHROS https://t.co/yZHMQjpMz8
Dr. John Cush RheumNow ( View Tweet)
Read my take on why TWITTER can be a + force in the field of RHEUM! @RheumNow @psufka RonanTKavanaugh @AWIRGOUP @creakyjoints @ACRheum @EULAR_org Social Media as a Creative/Disruptive Force in Rheumatology (or Why I Now Tweet) https://t.co/hvRyEREFvu

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Leonard Calabrese LCalabreseDO ( View Tweet)

Best Rheums go to the Best Meetings - RHEUMNOW LIVE - the next best Rheum CME meeting - Interactive panels, digital interface, Downloads, Shot Lectures, Big Name Faculty. Special discounted Holiday Registration rates. March 22-24 2019 in Ft Worth, TX https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

While flu activity is starting to rise in US, CDC issued Updated Influenza Antiviral Medications Summary for Clinicians | CDC. **DON’T USE: Amantadine OR Rimantidine to Tx flu ** ⁦@RheumNow⁩ ⁦@CDCFlu⁩ https://t.co/6W26hBEQvF

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k dao KDAO2011 ( View Tweet)

Comparison of pediatric (214) and adult (5348) GPA pts shows Pediatric GPA to have 30% more hospitalizations and 2-3 fold more leukopenia, neutropenia, hypogamma than adults. No diff in severe infections, major relapse, ESRD. https://t.co/Q1qX80RJDK

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Dr. John Cush RheumNow ( View Tweet)

By turning my back to the EMR, looking 1 on 1 at the patient and letting the patient tell their story, I collect more information, trust and goodness than I would ever from by reading reams of reports and results and "documenting"

Dr. John Cush RheumNow ( View Tweet)

No differences seen in the rates of major adverse CV events (MACE) between RA, axial SpA or PsA pts, suggesting inflammation, rather than a disease, drives CV risk. Data from a Swiss mixed retrospective/prospective cohort study https://t.co/Kn8a8tWId9

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Dr. John Cush RheumNow ( View Tweet)

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