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RA Disease Activity and Alcohol Use

Jack Cush, MD

Despite its well known toxicities, alcohol is known to be antiinflammatory. The effects of alcohol use in rheumatoid arthritis (RA) is less known, but a recent study suggests that alcohol consumption was dose-dependently associated with lower disease activity and higher health-related quality of life in RA patients.

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Worse Birth Outcomes in RA and SLE

Jack Cush, MD

A population-based retrospective cohort study patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and their infants demonstrated significant adverse pregnancy outcome, particularly the infants of women with SLE.

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Holes in TH17 cells release IL-1α on NLRP3 activation

EurekAlert!

Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and an international research team discovered.

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2022 Rheumatology Year in Review (1-6-2023)

Jack Cush, MD

Dr. Jack Cush reviews the best of 2022 in Rheumatology - highlights on new drug indications, breakthrough lupus therapies, new biosimilars and the multivitamin letdown.

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2022 Rheumatology Year in Review

Jack Cush, MD

2022 was a year of recovery, discovery, and some losses.  While still dealing with the aftermath of COVID-19, rheumatologists were resilient as leaders for their patients and research in advancing rheumatologic care.

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Worse Birth Outcomes in RA and SLE A population-based retrospective cohort study patients with RA or SLE and their infants demonstrated significant adverse pregnancy outcome, particularly the infants of women with SLE. https://t.co/oK05W8ncW0 https://t.co/3eJzHHOvXO

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Dr. John Cush RheumNow ( View Tweet)
anti-mitochondrial antibodies (AMA) in were assayed in 404 #RA patients & found to positive in 14-26%. Importantly AMA Abs were associated with erosive disease (p<0.05) and interstitial lung disease (p<0.01), independent of CCP or RF https://t.co/TW2xsa1igt https://t.co/jr1ltgGmdF

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Dr. John Cush RheumNow ( View Tweet)
473 RA pts from the BeSt study were analyzed. for correlation betw joint cumulative inflammation and radiographic damage. Cumulative jt swelling was signif correlated w/ future xray damage/erosions, less so for tender only jts https://t.co/DQ06VYBDxm https://t.co/PfRWCcti8T

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Dr. John Cush RheumNow ( View Tweet)
Population data on incidence of #RA from Northern Savo, Finland, 46 new RA cases in 2020; incidence seropos RA was 22.3 per 100K. Incidence did not differ by gender but decreased w/ age < 55 years, p = 0.003 (change in risk factors?) https://t.co/QxMwKh7wIU
Dr. John Cush RheumNow ( View Tweet)
Autoimmune Dz may be assoc w/ new-onset Atrial Fibrillation, esp in women. Population-based UK Biobank found significant increases for AFib in Rheumatic fever w/o CVD (HR 1.47), Crohn’ (1.23), UC(1.17), RA (1.39), PAN (1.82), SLE (1.82), PSS (2.32) https://t.co/rpIiztUfg9 https://t.co/FWmLiZ6x1S

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Dr. John Cush RheumNow ( View Tweet)
Status of #RA; an Egyptian College of Rheumatology study of 10,364 pts from 26 centers. Mean age 45 yrs, Dz duration 6.4 yrs, onset age 38. (F:M 5.4:1) DAS28 was 4.4  & HAQ 0.95  RF+ 74%, CCP+ 67% Rx use: MTX 78%, HCQ 74%, steroids 71%, Biologics 11.6% https://t.co/19omwKqAQl https://t.co/m04QabOwgZ

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Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine significantly lowers Alzheimer’s and dementia risk. Study of g 109,124 #RA pts starting HCQ or MTX. showed an 8-16% lower risk. https://t.co/gV4AYHRwmU https://t.co/crbTu1zr3E

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Dr. John Cush RheumNow ( View Tweet)
520 RA pts were screened with FibroScan (liver fibrosis)- F3 or F4 liver fibrosis seen 13.3% of controls vs 12.7% arthritis pts. MTX was not significantly correlated w/ higher FS scores. Liver stiffness was correlated w/ BMI, waist, male , age. https://t.co/nINWp8vbUu

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Dr. John Cush RheumNow ( View Tweet)

Open Access Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study 📰 https://t.co/reGuRVPQSG #dementia #rheumatoidarthritis https://t.co/0K7URVTkYO

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The Journal of Rheumatology jrheum ( View Tweet)
Dr. Kristi Kuhn & Univ of Colorado researchers have linked RA risk with the gut bacterium Subdoligranulum didolesgii. This could be pathogenically important and supports their "Mucosal origins hypothesis" to RA risk https://t.co/EMfNzWSPBK https://t.co/dp7p6vMI4W https://t.co/E1CBUPy2Wp

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Dr. John Cush RheumNow ( View Tweet)
Join us for RheumNow Live this March 18-19 in Dallas, TX! We're not like other meetings--we're answering the questions you want answered. RNL is a meeting to engage your mind and change your practice. Join us in-person or virtually! https://t.co/bMphD12Bie https://t.co/Hx0uHAIUWd

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Dr. John Cush RheumNow ( View Tweet)
Dr. Kristi Kuhn & Univ of Colorado researchers have linked RA risk with the gut bacterium Subdoligranulum didolesgii. This could be pathogenically important and supports their "Mucosal origins hypothesis" to RA risk https://t.co/xDyejVR8MW https://t.co/M663ziXOcT https://t.co/y7zpukZah5

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Dr. John Cush RheumNow ( View Tweet)
Rheums manage #RA. But patients have to manage RA and their lives - I wish we could provide better guidance to our patients about Life with RA. Heres one patient from Wash, DC who accomplished SO MUCH in 2022 and she has RA! @hirokonishimura https://t.co/QStFGZLsTR https://t.co/Q7GoYQYvwx

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Dr. John Cush RheumNow ( View Tweet)
2002-2019 Canadian study of Rheumatology care: access has improved but problems exist, esp w/ DMARD use. In 112,494 new RA pts, 84% saw Rheum <1yrs w/ 43% increase by 2019. Suboptimal DMARD use in elderly improved 55 to 69% https://t.co/tpv514P0GP https://t.co/AIRuf7u60d

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Dr. John Cush RheumNow ( View Tweet)
608 EARLY RA pts in BARFOT study had Xrays over time. 24% did not show Erosions after 8 yrs. Pt w/ NO Erosions were younger, younger, w Less ACR criteria, & seronegative at Dx. They had more TJC, less SJC, lower ESR, less DMARDs & pred Rx. https://t.co/5jYNd7bwE3 https://t.co/z3Y0TPJTwd

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Dr. John Cush RheumNow ( View Tweet)
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