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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com
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An outcomes study from the Leiden Early Arthritis Clinic (EAC) has shown substantially less diagnostic delay and better long-term outcomes when patients are referred to EAC compared to usual referrals.
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Dr. Jack Cush reviews the news and journal reports from this past week on Rheumnow.com - including obesity, disappointing durability with GLP-1 drugs, AI diagnoses and worries about CV risk in ANCA-associated vasculitis. And take this week's RheumIQ quiz!
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Smolen, Kerschbaumer, Aletaha, and Robinson have published a comprehensive review article of rheumatoid arthritis (RA) in JAMA, noting significant changes to our understanding and treatment guidelines.
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Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. New drugs approved, new drugs halted and some drugs out of control. Ready to test your knowlege? Take this week's quiz!
Dr. John Cush
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Obesity and Rheumatic Disease
Presented as part of RheumNow's "The Obesity Imperative" campaign.
https://t.co/d2fl4EJX8Q https://t.co/AZGfKRvZrx
Dr. John Cush
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Metanalysis of 87 studies shows predictors of #MTX response: early Dz, low dz activity, early MTX initiation, and absence of erosive disease. Smoking and higher BMI were linked to reduced efficacy. https://t.co/OfB09aHNOS https://t.co/4UiOgfW940
Dr. John Cush
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Early RA Referral Clinics Work!
An outcomes study from the Leiden Early Arthritis Clinic (EAC) has shown substantially less diagnostic delay and better long-term outcomes when patients are referred to EAC compared to usual referrals.
https://t.co/6vGd0S0V1W https://t.co/2ATEMRhtMM
Dr. John Cush
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Indian study of 85 #RA pts in LDA or better (DAS28-ESR ≤ 3.2). W/ 6 mos F/U, 39 (46%) had 1+ RA flare (DAS28 > 3.2); time to flare 12 wks (8–18) unrelate to Dz activity. Predictors: seropositivity (HR 2-2.3) https://t.co/ifqeoPtxpx https://t.co/ltx64X55fd
Dr. John Cush
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Single center study of FALLs in 124 ambulatory RA females ≥50 yrs.(age 68 yrs, DAS28 2.6, sarcopenia 16%, prior fall 25%). 27.4% had falls; predicted by prior fall hx (OR 2.76, hypnotics/anxiolytics (3.92), not steroids or sarcopenia (NS trend) https://t.co/J62RPF9rQs https://t.co/OKxdPl5Oev
Dr. John Cush
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JAMA: Review of Adult Rheumatoid Arthritis
This JAMA narrative review is a follow-up to their 2018 publication, informed by 123 articles (46 RCTs, 28 cohort studies, 11 systematic reviews/meta-analyses, 15 guidelines) covering epidemiology, pathogenesis, diagnosis, and https://t.co/6Fiu9iLF5I
Dr. John Cush
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TriNetX retrospective EHR study showed VTE in #RA not incr by taking JAKi. Pts undergoing THA/TKA Rx w/ JAKi (n 284) vs TNFi (n 288). VTE- 17 JAKi (6%) vs 11 TNFi (3.8%)- nonsignif incr (RR 1.57) https://t.co/OM5ipieQtr https://t.co/ng8b9EkWmT
Dr. John Cush
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QD Clinic: Weight Loss Changed the Course of RA
Dr. Bella Mehta, New York, presents this case which highlights that obesity may be a target for disease modification in rheumatoid arthritis, as part of RheumNow's "The Obesity Imperative" campaign, presented in September 2026. https://t.co/KNNS0cHmA4
Aravind Palraj
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The 1980s quietly rewired rheumatology.
Methotrexate became the anchor DMARD.
APS emerged as a distinct clinical syndrome.
SLE classification was standardized.
Cytokine biology began pointing toward the biologic era.
A decade that moved rheumatology from symptom control toward https://t.co/9NUXorQDTG
Dr. John Cush
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High BMI decreases the odds for MDA in PsA, esp w/ TNFi Rx (but not Inflx, IL-17i, IL-12/23i, IL-23i, JAKi). Longitudinal PsA cohort 1291 pts (mean BMI 29); Higher BMI independently assoc w/ signif. lower odds for MDA (OR 0.97), also female, age, smoking, FM & Xray damage. https://t.co/zAJ8Pmk1HY
Dr. John Cush
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Cohort analysis shows autoimmune rheum Dz (AIRD) pts who recv COVID vax w/ boosters & updates were 41%, 71%, and 69% less likely to have COVID-related hospitalization (vs no Vax). If only initial vaccine series (without booster/updated vaccine), risk reduction was 5.6%. (n= https://t.co/NdEKKWdOAy
Dr. John Cush
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Swedish study of 1097 #RA pts looked at modifiable healthy lifestyle habits (HLHs: EtOH use, smoking, physical activity). At Baseline, 56% had three HLHs , unchanged (58%) at Yr 3. Nonsmoking incr 77-83%, healthy alcohol from 85%-97%. but healthy PA decr 84-71%. Lifestyle modif. https://t.co/cDyQwiN6Ae
Dr. John Cush
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NEJM images: Jaccoud’s arthropathy is a chronic, deforming;from laxity of the ligaments & tendons (not damage to bone & cartilage). Deformities are reducible & no erosions on Xray. Jaccoud’s mimics RA, but most seen w/ SLE. https://t.co/99WDNcpT5c https://t.co/EdiGW1dDWY
Dr. John Cush
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QD Clinic: RA, IBD and Frank's sign
Daric Mueller, PA-C, St. Clair Shores, MI, presents a case called, "Rheumatoid Arthritis, IBD and Frank's Sign", as part of RheumNow's "The Obesity Imperative" campaign presented in September 2026.
https://t.co/XMD0b35fiu https://t.co/9WUdZKAR0w
Dr. John Cush
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“ABCDE” Approach to Difficult-to-Treat Rheumatoid Arthritis
The proposed approach to D2T-RA is based on the EULAR definition (having failed 2 or more b/tsDMARDs). It is estimated that up to 20% of RA patients meet this D2T-RA definition and can be plagued by active or https://t.co/o39IREvjI4
