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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

Jack Cush, MD

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on RheumNow.com, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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High Risk Cancer Profiling with Inflammatory Myositis

Jack Cush, MD

A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs).

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Alveolar Hemorrhage and Mortality in Lupus

Jack Cush, MD

Metanalysis of patients with diffuse alveolar hemorrhage (DAH), show this to be a rare and life-threatening complication of systemic lupus erythematosus (SLE), that is more apt to affect older, severe lupus patients with active infection.

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ACR Promotes New COVID-19 Vaccine Clinical Guidance for Rheumatic Patients

Jack Cush, MD

The American College of Rheumatology has published a draft guidance on the use of COVID-19 vaccination in rheumatic disease and musculoskeletal disease patients, based on the efforts of the North American Task force. The document provides guidance to rheumatology providers on the use of the COVID-19 vaccine and the associated management of RMD patients around the time of vaccination. Here is a summary of the recommendations.

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Comorbidity and Drugs Drive COVID-19 Severity and Survival in Rheumatic Disease

Jack Cush, MD

While comorbidities are associated with severe COVID-19 infection, it appears they also influence severity and survival in rheumatic disease (RMD), according to a a French cohort study,

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QD Clinics- The Sawtooth Steroid Taper Sawtooth Steroid Taper Surgery Rules for DMARDs & Biologics RA & DVT Traveling to Medical Meetings during COVID Hemoptysis and SLE When to do Genetic Testing in Febrile Patients https://t.co/dZLqGUyizG https://t.co/PYsH7K6ByB

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Dr. John Cush RheumNow ( View Tweet)
Single center study of 43 pregnant SLE pts (57 pregnancies) - 96.5% intended to breast feed & 72% did (same as gen population). But SLE women had more early discontinuations @ 3 mos (assoc w/ smoking, BMI, joint Dz) HCQ assoc w/ longer breastfeeding https://t.co/VVVTVUeOT5

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - Hemoptysis and SLE Key Features of Alveolar Hemorrhage in lupus https://t.co/qNZYDYmn70 https://t.co/sitc7Tlf5V

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Dr. John Cush RheumNow ( View Tweet)
Alveolar Hemorrhage and Mortality in Lupus Metanalysis of patients with DA), show this to be a rare and life-threatening complication of SLE, that is more apt to affect older, severe lupus patients with active infection. https://t.co/EILQZTYYjk https://t.co/kDAFuYIJuH

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Dr. John Cush RheumNow ( View Tweet)
RWCS Highlights - Day 4 from Dr. Rachel Tate ( @uptotate) -Novel Therapies Year in Review (RA, SLE, OA) -Novel concepts in Pediatric Rheumatology -TeleRheumatology Update: Post-COVID, Pre-?? https://t.co/JoTV25suxD https://t.co/Id19zgRT37

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Dr. John Cush RheumNow ( View Tweet)
Video---Proposal of Novel Multimodal Outcome Instrument for Assessing SLE Activity--RWCS 2021 Poster Session by Dr. Barbara Jacobs, UC-San Diego https://t.co/3H4iNssyrZ

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Dr. John Cush RheumNow ( View Tweet)

Potential, Phase 2, novel therapies in SLE: OBIN (anti-CD20 mAb), BIIB059 (BDCA2 binder), & IBD (modulator of the E3 ubiquitin ligase complex) showed efficacy. EVO (oral BTKi) failed to show efficacy. Drs. Fleischmann and @alvinwellsmd #RWCS2021 #RWCS @RheumNow @RWCSmtg https://t.co/i04nx71GSx
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Fleischmann describes research SLE metrics at #RWCS2021 #RWCS @RheumNow @RWCSmtg https://t.co/WaaMv9ybRk
Dr. Rachel Tate uptoTate ( View Tweet)
Proposal of Novel Multimodal Outcome Instrument for Assessing SLE Activity RWCS 2021 Poster Session by Dr. Barbara Jacobs, UC-San Diego https://t.co/3H4iNssyrZ

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Dr. John Cush RheumNow ( View Tweet)

Danish Cohort study of 5310 cutaneous LE or SLE pts between 1995-2014 (7-8 yrs F/U and 40.724 PYs) shows an overall increased cancer risk for CLE (SIR 1.35)and SLE (1.45), esp a 3-4 fold increased risk for NHL, hematological, pancreatic and lung cancers https://t.co/0FialHXVvb

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Dr. John Cush RheumNow ( View Tweet)

Text mining of #EHRs can be used to accurately identify and characterize patients with #SLE #Lupus #Rheumatology #RheumTwitter https://t.co/JayhTRRPz9

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Rheumatology Advisor RheumAdvisor ( View Tweet)

RheumNow Podcast is up! Tofacitinib Safety Concerns - covering vagal nerve stimulation, IL-23 in PsA, Diet & RA, NSAIDs & COVID, Plaquenil side effects and more. Watch it here>> https://t.co/7RDZ0avZLC ListeniTunes>>https://t.co/FHJv01AAbC or SoundCloud>>https://t.co/yJWJNa6CRL

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Dr. John Cush RheumNow ( View Tweet)

Don’t Hold the Benlysta, Take the Vaccine The RheumNow podcast is available on Soundcloud, https://t.co/fxtCOkxTER, and Apple/Android car play. https://t.co/34XMLMZGMH

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Dr. John Cush RheumNow ( View Tweet)

Download available--Maintaining a Healthy Immune System https://t.co/wiWzZldnik https://t.co/ZL3r3dHPC2

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Dr. John Cush RheumNow ( View Tweet)
High Placebo Responses in SLE Trials A systematic review in randomized controlled trials (RCTs) of non-renal, non-neuropsychiatric systemic lupus erythematosus (SLE) patients showing unexpectedly high placebo responses. Read more: https://t.co/zUPsVFEz4n https://t.co/Gk7ke4hBwY

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Dr. John Cush RheumNow ( View Tweet)
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