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Dr. Cush reviews the news, and kicks off ACR21 learning and how to take in the annual meeting.
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Article
Since the start of the pandemic, hydroxychloroquine (HCQ) was forced into the limelight for the prevention/treatment of COVID-19.
Article
The pharmaceutical companies will feature the results of their pivotal clinical trials and data analyses at ACR Convergence 2021. Below is a listing of some of their best studies for you to review and look for in the meeting.
Article
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that Black people living with systemic sclerosis may have more severe disease and worse prognosis than patients in other racial or ethnic groups, and these worrying disparities may be driven by several socioeconomic factors (Abstract #1854). This poster will be presented Tuesday morning, November 9, 2021 in the Clinical Poster III (1836–1861) section on Systemic Sclerosis & Related Disorders.
Bella Mehta
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Machine learning predicted lupus nephritis in #SLE patients in real world data #ACR21 @RheumNow #abst0324 https://t.co/67HBT7F2GO
TheDaoIndex
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Don't wait!
DR. Petri wants us to change paradigm of how we treat aggressive lupus nephritis: early, aggressive, and multimodal. Does not matter if you add on VCS or BLMB, just don't treat LN with MMF monotherapy.
#ACR21 #GreatDebate @rheumnow https://t.co/ebSiic095h
TheDaoIndex
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"I don't want rheumatologist only use BLMB and nephrologist using only VCS."
- Dr. M Petri on how we should work together with nephrologists on managing lupus nephritis.
(She did give a final dig & added "BLMB can be used with any GFR")
#ACR21 #GreatDebate @rheumnow
TheDaoIndex
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#GreatDebate: add on BLMB vs. VCS to MMF for LN
Dr. Petri argues for BLMB b/c:
👉cost is less
👉better adherance
👉not good for class V
👉voclosporin had greater nephrotoxicity
👉insuff data in pregnancy, but not contraindicated like VSC #ACR21 @rheumnow https://t.co/mk2eXwkxcG
Eric Dein
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#ACR21 Great Debate Dr. Brad Rovin:
Voclosporin: Combo with MMF is effective pts of diverse racial and ethnic backgrounds.
⭐️Big plus for a disease with large healthcare disparity issues
@Rheumnow https://t.co/rMpCRPLLGQ
sheila
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KL-6, Anti-Ku, anti-CENPB were assoc'd w/ #myositis &/or ILD in #lupus patients accdg to this study by Dr. T Cotton et al. This may help identify patients at risk for developing such.
@RheumNow #ACR21 abs0330 https://t.co/p0uxBOTLZm
Robert B Chao, MD
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Great Debate on Voclosporin vs. Belimumab in Lupus Nephritis therapy.
Dr. Petri argues Belimumab has less potential AE including infections, cardiovascular risk, malignancy potential. No drug-drug interactions.
What would you choose?
#ACR21
#ACRBest
@RheumNow https://t.co/FywUp3zCj2
Eric Dein
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@jhrheumatology Dr. Petri - if Lupus nephritis biopsy is very active start a dual therapy with MMF right away.
▶️ If not, continue to re-evaluate at 3 and 6 months for early combo therapy
#ACR21 Great Debate
@Rheumnow https://t.co/ctKdbWTMqy
David Liew
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How can we tell whether a patient already on rituximab will have an immunogenic response to Pfizer COVID-19 vaccination?
Better chance of response if:
- RA or SLE, not AAV or IIM
- high serum IgG pre-last RTX
- longer time since last RTX
Israeli data #ACR21 ABST0437 @RheumNow https://t.co/yyuFd0eDH6
Eric Dein
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@jhrheumatology Dr. Petri at #ACR21 Great Debate.
Safety issues with Voclosporin:
1) Nephrotoxicity
2) Infection
3) CV Risk Factors
4) Malignancy
5) Neurologic toxicity
6) Osteoporosis
7) Drug interactions
8) Deaths
9) Pregnancy contraindication
@RheumNow https://t.co/wjluivmKNt
TheDaoIndex
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Dr. Chambers review @MotherToBaby prospective data on HCQ use in pregnancy (n=279):
👉no major defects (regardless of dose)
👉no oral clefts
👉SGA slightly lower in exposed group b/c of underlying dz
👉no case of retinopathy in babies after 1 year f/u @rheumnow #Pregnancy https://t.co/vw2eryFgro
Md Yuzaiful Md Yusof
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#Abstr0076 #ACR21 Can we predict #thrombosis in #lupus patients? Predictors of serology transition at 5yrs:
✅LAC+ to LAC-:Afro-American,HCQ and normal C3
⛔️LAC+ to 🩸Clot:Obesity, low C3 and not on HCQ
Data need in those with Triple Positivity @RheumNow https://t.co/byeL5NjVUS https://t.co/CchtZir2GN
Md Yuzaiful Md Yusof
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Either we need to review the Yearly PAP cervical screening in SLE women or work hard to improve patient awareness. Suspect the latter as time between tests was over 4 years late 😱 and 2.7% developed cancer #ACR21 #Abstr0133 @RheumNow https://t.co/wm01MfoFjf https://t.co/blD8WafZsE
Md Yuzaiful Md Yusof
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#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph
TheDaoIndex
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👉Voclosporin for SLE: rapid control of proteinuria (50% reduction over 29 days in UPCR w/o high side effects) @rheumnow #YearInReview #ACR21
Are you all starting to use this drug now? It has helped my patients; pretty well tolerated. https://t.co/zqJRsjnV4n
Eric Dein
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AURORA 1, Year in Review: Voclosporin as add-on therapy lupus nephritis. Approved in 1/2021 for active lupus nephritis, very positive data @rheumnow #ACR21 https://t.co/rudYD1OC59
