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Polyautoimmunity in RA, Regardless of ACPA Positivity
While it is believed that autoimmunity follows autoantibody positivity, a Danish study shows the incidence of polyautoimmunity to be similar in rheumatoid arthritis (RA) patients who are either anticyclic citrullinated peptide antibody (ACPA)–positive or ACPA–negative.
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19% Arthritis Prevalence in the USA
According to the National Health Interview Survey (NHIS), in 2022, the prevalence of diagnosed arthritis in adults was 18.9% (women 21.5%, more than men 16.1%). These numbers are down since the CDC's MMWR report of 2019–2021, where is was estimated 21.2% of U.S.
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Early-onset Osteoarthritis is a Growing Health Problem,
Data from the Global Burden of Diseases Study 2019, suggests that early-onset osteoarthritis (OA) (before age 55 yrs) is an emerging health issue that parallels societal problems of obesity.
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Preoperative Delay & Education Benefits Arthroplasty Patients
Having patients waiting for knee arthroplasty undergo a preoperative program of weight loss, exercise, and other interventions gave them modestly improved pain, function, and quality of life, a small randomized trial showed.
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Can Mycophenolate be Stopped in Stable SLE?
In patients with clinically stable systemic lupus erythematosus (SLE) and lupus nephritis, the withdrawal of mycophenolate mofetil was not significantly inferior to mycophenolate maintenance, but MMF withdrawal had numerically more reactivations, while MMF maintenance had more infections.
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COVIDs Extended Risk for Rheumatic Disease
Annals of Internal Medicine reports a large, binational study finding SARS-CoV-2 infection was associated with an increased risk for autoimmune inflammatory rheumatic diseases (AIRDs) that extends up to 12 months after infe
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