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ILD Onset in MDA-5 Dermatomyositis
Anti–melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is a rare, aggressive and progressive subtype of DM.
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World Congress on OP, OA & MSK Disorders
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EurekAlert!
Bone and musculoskeletal disease researchers and physicians from around the world will meet today in London, UK for the opening of the largest scientific event in the field, the World Congress on Osteoporosis, Osteoarthritis and Muscul
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Neuropsychiatric SLE - 2/3 Improved at 12 Months
The management and outcomes of neuropsychiatric systemic lupus erythematosus (NPSLE) can be challenging as there is limited data.
Best Imaging in Giant Cell Arteritis - US, PET, MRI?
Imaging is often instrumental in diagnosing and staging patients diagnosed with giant cell arteritis (GCA).
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JAMA: SLE Review
Drs. Caroline Siegel and Lisa Sammaritano (from HSS in NYC) have published an impressive overview of systemic lupus erythematosus (SLE) in JAMA. This timely, well-written review covers the many complexities of this multi-organ disorder that affects nearly 3.4 million people worldwide.
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Is IL-6 a potential therapeutic target in neuropsychiatric lupus (NPSLE)?
Just published in the Journal of Neuroinflammation- Some interesting findings from the Putterman lab in a murine NPSLE model... https://t.co/7yn2o7ZRxS
chaim putterman ChaimPutterman ( View Tweet)
In RA, previously affected Jts more likely to flare ("joint-specific memory") ?mediated by synovial resident memory T cells, predominantly CD8+ T cells, with a restricted TCR repertoire, responding to specific Ags by releasing chemokines & cytokines https://t.co/VfFZ03yZYL https://t.co/npX3TGDe5A
Dr. John Cush RheumNow ( View Tweet)
Cross-sectional study of7887 NY & IL nurses: between 2018-21 top reasons for 2287 leaving nursing were planned retiring (39%), burnout (26%), insufficient staffing (21%), family obligations (18%) & COVID (17%)-- all addressable by health care employers https://t.co/Ls6p060mFB https://t.co/Pxpa8fqchz
Dr. John Cush RheumNow ( View Tweet)
Seasonal Pathogens and Henoch-Schönlein Purpura
Epidemiologic studies of Henoch-Schönlein purpura (HSP) have suggested seasonal variation in occurrence rates (higher from September-April, lower in June-August), suggesting a role for infectious triggers.
https://t.co/MmuVVziqv8 https://t.co/PhidOFTbFV
Dr. John Cush RheumNow ( View Tweet)
Pearl: Patients with persistent TMJ pain are more likely to have fibromyalgia than inflammatory or degenerative arthritis (as the underlying cause of their chronic pain) https://t.co/gCEm8A3RAT https://t.co/bvK2ii4fXP
Dr. John Cush RheumNow ( View Tweet)
IL-1 recept accessory protein (IL1RAP) shown to block mediators (IL-1, IL33, IL36) that may drive systemic sclerosis. In vitro, IL1RAP inhibited fibroblasts and endothelial cells; in mouse models of SSc anti-IL1RAP decr dermal & pulmonary fibrosis. https://t.co/jWjUMKdqGw https://t.co/O3o5iDHD6X
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Top 5 Clinical Pearls in RA Management
https://t.co/DphF8HcuHD https://t.co/CF9UuBCUxS
Dr. John Cush RheumNow ( View Tweet)
SLE in JAMA (authored by Drs Siegel & Sammaritano at HSS), impressive, full-read review, Covers:
- Presentations: skin, Jts, brain, heme, etc
- Treatments
- Prognosis
- Complications: CV, infx, CA
- FAQs
https://t.co/TPkm3BlrSw https://t.co/FqN1ZXyv4Y
Links:
Dr. John Cush RheumNow ( View Tweet)
1/600 Falls May Die (4.5.2024)
Dr. Jack Cush reviews the news and Journal reports from this past week on RheumNow- including problems w/ falls, pain and treatment of Dupuytren’s contractures.
https://t.co/37JSS1fbLi https://t.co/WEwjntAQEt
Dr. John Cush RheumNow ( View Tweet)
Serious Infections in Takayasu arteritis
The large vessel vasculitis, Takayasu arteritis (TAK), carries a significant morbid risk and a cohort analysis shows these patients are also at high risk of serious infection with resultant higher risk of death.
https://t.co/qqtpCMYnZf https://t.co/ZlxATKVQIA
Dr. John Cush RheumNow ( View Tweet)
Canadian OBRI study in 692 RA pts shows pts treated w/ triple DMARD (MSH) stayed on Rx longer (15 mos) compared to MTX+LEF (9.6 mos); not significant but MTX/SSZ/HCQ had signif lower DAS28 @ 6 mos (3.4 vs 3.9) & at 12 mos (3.2 vs 3.5, p=0.0005) https://t.co/tuIigaswDK https://t.co/DAh3lgRufA
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Dr. John Cush RheumNow ( View Tweet)
Primary care pop. study pts shows poor health literacy in gout pts assoc. w/ more gout flares. Study of 551pts; 30% w/ 2+ flares in 12 mos; 9.4% w/ poor health literacy. pts had more flares (OR 4.1) & hx of oligo/polyarticular flares (OR 1.93) https://t.co/tDiFqixbLV https://t.co/Kb75iJwTZE
Dr. John Cush RheumNow ( View Tweet)
#RNL2024 @RheumNow
@AlexisOgdie
Many therapies for SpA - but ONLY TNFi, IL17i, and JAKi for AxSpA
Check out https://t.co/3918uYvdFj to help guide treatment decisions: Prior therapies? enthesitis? concomitant IBD/uveitis? comorbidities? Pt preferences? https://t.co/6ugueBPMTy
Dr. John Cush RheumNow ( View Tweet)
TAPIR study shows that GPA patients treated with rituximab can be safely weaned off low dose prednisone. But. 20% risk of relapse in those treated with non-RTX regimens @VasculitisBCN24 #vasculitis https://t.co/jDy0lOQQIP
Catherine Hill CatherineL_Hill ( View Tweet)
Human touch. A systematic review that underscores the physical and mental health benefits. The essence of medicine that will not be provided by #AI
https://t.co/OvCDJYAsoS @NatureHumBehav @j_packheiser @helenahhartmann
@FredericMichon @GazzolaValeria @sbl_nin https://t.co/YuAiKtq87p https://t.co/Sxj1LfO5ZG
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Eric Topol EricTopol ( View Tweet)