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Lupus Worries (3-25-22)
Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.
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Stable Low Risk of Acute Coronary Syndrome in RA
A Nordic multinational collaborative study examined the risk of acute coronary syndrome (ACS) in rheumatoid arthritis and found a less than 2 fold increased risk of ACS patients initiating biologic disease-modifying antirheumatic drugs (bDMARDs) with little risk variation with short-ter
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ICYMI: Drugs for Pregnancy Hopefuls
A Young Woman has uncontrolled RA, but wants to get pregnant.
What do you chose?
https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd
Links:
Dr. John Cush RheumNow ( View Tweet)
High disease trajectory despite disease control (^HAQ > DAS28) in RA is more likely with higher pain, fatigue & depression. 10 ys study of 2500 RA pts from NOAR, ESPOIR, ERAN) https://t.co/mrB7fog6PD https://t.co/tqm3LPkOdM
Links:
Dr. John Cush RheumNow ( View Tweet)
Having the MUC5B promoter variant increases odds of RA-ILD w/ earlier onset in RA, esp w/ older age of RA onset. Mass Gen Biobank study of 1,005 RA pts; MUC5B found in 15% w/ incr risk of RA-ILD (OR 3.34) & RA onset after 55 yrs (OR 1.52) https://t.co/5odVWnpuxo https://t.co/zeKxADTSBZ
Links:
Dr. John Cush RheumNow ( View Tweet)
Aging & Inflammatory Rheumatic Dis is a growing Problem:
- Multimorbidity drives polypharmacy & compounds safety risks
- More malnutrition, sarcopenia & frailty
- Phenotype of Rheum Dz changes w/ age
- Tx differs for the elderly
- Elder RA is undertreated https://t.co/J2q0mEOqDd https://t.co/VfolGeYx6V
Dr. John Cush RheumNow ( View Tweet)
Phases preceding RA diagnosis.
@karen_kc123 @RheumNow #RNL2022 https://t.co/KJT9ml8ZJY
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Completed early RA prevention trial!
One dose of Rituximab at day zero in the PRAIRI Trial, delayed onset of RA diagnosis.
After 36 months mo difference .
@karen_kc123 @RheumNow #RNL2022 https://t.co/R3639V6b07
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Patient-centered, holistic approach in #multimorbidity management.
🔑 Patients with #RA and #MM need help and coaching in guiding and directing their care.
🔑 Good communication with healthcare provider is the key.
@RheumNow #RNL2022 https://t.co/iLrZAT0y9r
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
Approaching comorbidities!
Elena Myasoedova @RheumNow #RNL2022 https://t.co/Y3JNsBT9bJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
ACPA is a strong predictor for RA development.
any ACPA : 30% developed RA within 3 years.
High titer ACPA: 50% developed RA with 3 years.
Finally ACPA Titer Matters?!
@karen_kc123 @RheumNow #RNL2022 https://t.co/blbVovf1KZ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Healthy behaviors (moderate EtOH, healthy body weight, no smoking, healthy diet, physical activity) associated with lower RA risk
"Chronic systemic inflammation fans the flames of brewing RA"
@RheumNow #RNL2022 https://t.co/gAerZaAcso
Robert B Chao, MD doctorRBC ( View Tweet)
Family history risk includes genetic and shared environmental factors
@RheumNow #RNL2022 https://t.co/3J4nisbSX1
Robert B Chao, MD doctorRBC ( View Tweet)
ACPA prior to RA diagnosis.
Notice epitope spreading proceeding diagnosis!!
@karen_kc123 @RheumNow #RNL2022 https://t.co/glgrOdVyyJ
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Completed Early RA prevention trials using agents like steroids, RTX, atorvastatin, abatacept
No sig difference in steroids, atorvastatin
RTX delayed onset but no overall diff
Abatacept decreased RA progression at 1.5 years
@RheumNow #RNL2022 https://t.co/v7WxI2P7r5
Robert B Chao, MD doctorRBC ( View Tweet)
@Janetbirdope on drug cycling in #RA. What’s beyond TNFi failure? No golden rule, but:
👉🏻 switching to non-TNF can be superior than staying with the TNFi class
👉🏻 response to other bDMARs maybe blunted in non-TNFi naive
👉🏻 JAKi can be a good choice for some @RheumNow #RNL2022 https://t.co/25MiiFh2CK
Elena MyasoedovaMD MyasoedovaElena ( View Tweet)
How NOT to get rheumatoid arthritis. Excellent tips by @karen_kc123 #RNL2022 #rheumatoidarthritis https://t.co/brLeWzioQD
Jonathan Hausmann MD hausmannMD ( View Tweet)
Patients often ask me what they can do on their part to help their disease... this is it! @karen_kc123 reviews the modifable risks in RA. @rheumnow #RNL2022 @CreakyJoints https://t.co/FM0BtNX6eb
TheDaoIndex KDAO2011 ( View Tweet)
#Rheumatoid arthritis- is it all or partially in your genes 🧬? Many genes are not sufficient or necessary to produce #RA. Genes were used in a study to predict development of RA better than clinical parameters. But not ready for prime time YET #RNL2022 @RheumNow @karen_kc123 https://t.co/J5aBs4iLbR
Janet Pope Janetbirdope ( View Tweet)
Dr. Elena Myasoedova on Multimorbidities and RA
Important to recognize multimorbities are 2-3x higher in RA and how it impacts our RA pts
@RheumNow #RNL2022 https://t.co/N6VPdU6wzV
Robert B Chao, MD doctorRBC ( View Tweet)
