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ICYMI: Retrospective study of 98 patients with X-linked agammaglobulinemia (XLA) shows arthritis seen in 46% - more oligo- than polyarthritis, affecting . Knee, hip, and ankle. IVIG response rates around 70%; many w/ arthritis had missense mutation https://t.co/qT49OXLyKU https://t.co/Drz1poV1AH

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Dr. John Cush RheumNow ( View Tweet)
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Hand OA and Heroes in Rheumatology (2.11.2022)

d Jack Cush, MD

Interesting reports this week about dementia, who gets hand OA and a great list of women Heroes and Pillars of Rheumatology. Tune in as Dr. Jack Cush reviews the news and journal articles from this past week in RheumNow.com.

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Analysis of nearly 1000 undifferentiated-arthritis(UA) pts show that MRI use is most effective when applied to those who are seronegative or who have oligoathritis. https://t.co/aKIp2rZSNk

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Dr. John Cush RheumNow ( View Tweet)

DIP,OA

Why Would Hand OA Be Less Severe in Black People?

d MedPage Today

Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.

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ICYMI: Radiographic progression in AxSpA studied in 101 Spanish Pts - pts w/ sustained low ASDAS had less XRay progression than those with active Dz (2.33 vs 1.76, p=0.027). Long term TNFi use didnt influence progression until the 3rd Yr https://t.co/TchcLL2ivN

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Dr. John Cush RheumNow ( View Tweet)

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An Ounce of Prevention (2.4.2022)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout. 

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ANCA, vasculitis, test

ACR/EULAR 2022 Classification Criteria for Microscopic Polyangiitis

d Jack Cush, MD

The 2022 ACR/EULAR  classification criteria for microscopic polyangiitis (MPA) have been developed, validated and are now ready for use in clinical research.

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GWAS study in RA used to develop polygenic risk score (PRS) for Xray progression (training set = 500 and validated testing set= 740). Risk factors for severe XRAY progr = PRS (P=0.00019), female (P=0.0033), ACPA (P=0.0023), BMI (P=0.031) https://t.co/dwDSnTFUqs

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Dr. John Cush RheumNow ( View Tweet)

hands.stiff2_.jpg

Referral Rules for At-Risk Inflammatory Arthritis

d Jack Cush, MD

A prospective primary care study of patients at-risk for inflammatory arthritis (IA) showed that progression to IA was most likely in those with high anti-CCP antibody titers levels and involvement of the hands/feet/ IA.

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hip.fx2_.jpg

Fracture Risk with Osteoporosis Drug Holidays

d Jack Cush, MD

While bisphosphonate drug holidays are recommended, there are few comparative studies.

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PSS.scleroderma.arthritis.contractures

Autoantibody Associations in Systemic Sclerosis

d Jack Cush, MD

Analysis of two large cohorts of systemic sclerosis (SSc) patients shows a signfiicant minority of patients to have autoantibodies typical of rheumatoid erosive arthrits, but their presence in SSc patients was associated with unique manifestations of SSc. 

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Feet, foot

Pre-clinical RA: starting off the wrong foot

d Aurelie Najm, MD, PhD

Patients with clinically suspect arthralgia can represent a challenge for clinicians, in a sense that there are not yet reliable markers to predict evolution to clinical RA nor enough evidence to support routine prescription of conventional synthetic DMARDS or biologic treatments in this setting.

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SI AS SpA ACR

TNF inhibitors and radiographic progression in axSpA

d Aurelie Najm, MD, PhD

A remaining challenge for clinicians is the ability to delay, if not completely stop, structural progression in patients with axSpA, whether they are diagnosed with radiographic (r-axSpa) or non-radiographic (nr-axSpA) disease.

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heel enthesitis spur calcaneal

Predicting RA, and Treatment of Subclinical Arthritis

d Meral K. El Ramahi, MD, FACP, FACR

Identifying patients that will develop RA in situations of seropositivity without overt clinical arthritis or identifying patients with undifferentiated oligo/polyarthritis that will develop RA remains a challenge in the field of rheumatology. 

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great Thieves market another dx to consider for ? inflammatory arthritis swelling/stiffness post cold exposure Microgeodic Disease-digital swelling/pain likely from bone infarction 2/2 to cold induced vasospasm characteristic x ray/MRI findings on poster #ACR21 #meded https://t.co/eq0aOlcB7I
Adam J Brown AdamJBrownMD ( View Tweet)
Echos in PsA, RA: 🔹Diastolic dysfxn: 52% of PsA and RA (!), controls 5% 🔹Mitral regurge PsA 84%, Ra 53%, controls 10% 🔹Mild pulmonary valve regurge higher in PsA (Diastolic dysfxn has been seen in prior RA studies) https://t.co/QCKR5itfYj #ACR21 Abst1308 @RheumNow

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Pedro Castillo _Castillo_Pedro ( View Tweet)

Calcium hyperproficiency is a rare complication of vitamin D deficiency, where excess calcium from bone resorption forms complex structures resembling primary teeth. Neoformed teeth grow on different bones, such as this patient's hand, causing fractures and joint dysfunction. https://t.co/oGYCYkh1WD
Eduardo Valdés-Hevia 🦟 Valdevia_Art ( View Tweet)
#ACR21 @RheumNow Abst#0364 by Wetterslev et al. sought to identify axSpA characteristics of patients tapered off TNFI and showed clinical and radiographic improvement. 🔽52% were tapered off ⭐️The highest predictor of success is a low physician global VAS score

swethaann23 swethaann23 ( View Tweet)

Completely new one for me, Dr Taniguchi presenting on using ear ultrasound to diagnose and monitor disease activity in relapsing polychondritis. Appears useful, I suspect in clinical practice more so for diagnosis. Abstr#0169 #ACR21 @RheumNow https://t.co/PLJtkYkP3A
Richard Conway RichardPAConway ( View Tweet)
DCVAS testing results in GCA. @davidliew @philipcrobinson are you guys essentially not imaging anyone in anyway? What's going on? #ACR21 @RheumNow https://t.co/IMr5ee2Iea
Richard Conway RichardPAConway ( View Tweet)

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