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The Last Word on JAK Inhibitor Safety & 1133 Study (1.28.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  This week a trifecta of Gout reports and the last word on the ORAL Surveillance study...

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MMWR: Booster Vaccine Efficacy in Immunosuppressed Patients

CDC/MMWR

For adults aged ≥18 years who received 2 doses of an mRNA COVID-19 vaccine, a third dose increased vaccine effectiveness (prevention of hospitalization) among adults without (82% to 97%) and with immunocompromising conditions (69% to 88%), with near similar efficacy.

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3rd Vaccine Dose May Benefit ANCA-Associated Vasculitis Patients

Jack Cush, MD

ARD has publish a prospective, multicenter, observational study of vaccination outcomes in antineutrophil cytoplasmic antibodies associated vasculitis (AAV) patients, showing that AAV patients may not be adequately protected after standard two-dose COVID-19 vaccination, but that a third

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COVID Test Antibody

Weak Vaccine Responses in ANCA-Associated Vasculitis Patients

MedPage Today

Patients with ANCA-associated vasculitis (AAV) did not mount durable antibody responses to the SARS-CoV-2 Delta variant after the standard two-dose regimen of the Pfizer-BioNTech vaccine -- and for those taking rituximab (Rituxan) as maintenance therapy, even a third dose wasn't much help.

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The Overpricing of Drugs (1.14.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. This week we discuss amputations, a $57 billion RA market, an FDA approved drug for Cat arthritis and drug that works in Sjogren's.

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Hold Myophenolate or Not with COVID-19 Vaccination?

Jack Cush, MD

While the American College of Rheumatology recommends holding mycophenolate (MMF) in rheumatic and musculoskeletal diseases patients (RMD) receiving COVID-19 vaccines, there is limited data on such an approach. A recent cohort study of RMD patients showed that holding MMF yielded higher antibody responses than continuing MMF.

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COVAX Registry: Safety of COVID-19 Vaccines in Rheum Patients

Jack Cush, MD

The EULAR Coronavirus Vaccine (COVAX) physician-reported registry has shown that the use of COVID-19 vaccines in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD) is effective, safe, and well tolerated.

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ICYMI: MMWR reports >40,000 pregnant women who received COVID-19 vaccination during pregnancy- VAX not associated with preterm birth or small-for-gestational-age at birth overall compared with unvaccinated pregnant women. https://t.co/GtRMsNrFnn

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From 1969 hospitalized COVID Spanish pts (46% F, age 61), 31 pts w/ preexisting RMD -- they did not have more long-term post-COVID sxs (OR 1.46; 0.89–2.4), functional limitation (OR 1.058), anxiety, depression or MSK pain vs non-RMD https://t.co/IYJz5zFoLe

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: JAMA reports that between Dec 2020 and July 2021, COVID-19 vaccination saved nearly 241,000 lives, prevented 1, 133, 617 hospitalizations and prevented more than 14 million COVID-19 cases (all in 1st 6 mos of the COVID vaccines) https://t.co/q9TvLjtY9p

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Dr. John Cush RheumNow ( View Tweet)

3rd Vaccine Dose May Benefit ANCA-Associated Vasculitis Patients https://t.co/UXUryaQ7Fz https://t.co/p40xND4lVP

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Dr. John Cush RheumNow ( View Tweet)
How's the United States doing on boosters? Trailing a long list of countries, including Serbia, Slovenia, and Lithuania @OurWorldInData https://t.co/cOCVoyuqT3
Eric Topol EricTopol ( View Tweet)
How Bad and How Far? CDC says to date, in the USA, there have been 6,715,937 COVID cases and 850,575 deaths from COVID-19. A total of 249,393,487 (75.1%) have recv at least one VAX dose, 209,312,770 (63%) fully VAX, 38.7% had a booster dose https://t.co/M9fYWL80ae

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Dr. John Cush RheumNow ( View Tweet)

COVAX Registry: Safety of COVID-19 Vaccines in Rheum Patients  https://t.co/dzDuza09JW https://t.co/HqL7nWdaP0

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Dr. John Cush RheumNow ( View Tweet)
World Health Organization has recommended baricitinib & sotrovimab for COVID-19 (both already given EUA by the FDA). BARI (+/- steroids) given as 4 mg qd to severe hospitalized COVID. Sotrovimab, is for outpt, less severe disease. https://t.co/Hv8YdWUoYk https://t.co/l98zcyfGRk https://t.co/RAHKhqPWjp

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Dr. John Cush RheumNow ( View Tweet)
JAMA reports that between Dec 2020 and July 2021, COVID-19 vaccination saved nearly 241,000 lives, prevented 1, 133, 617 hospitalizations and prevented more than 14 million COVID-19 cases (all in 1st 6 mos of the COVID vaccines) https://t.co/VIcwcPwbjn

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: JAMA study shows that, compared with usual care, colchicine did not significantly reduce mechanical ventilation or 28-day mortality in patients hospitalized with COVID-19 pneumonia (HR 0.83; 95% CI, 0.67-1.02; P = .08). https://t.co/72P5EHwD8l

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: Patients on biologics are NOT at higher risk for COVID-19 infx. Retrospective matched cohort study compared 7631 Biologic Rx pts to 74910 matched cohort with equal Infx & death rates. COVID infx assoc w/ age, minorities, more comorbidities https://t.co/lY1MVpBoF1

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Hold Myophenolate or Not with COVID-19 Vaccination? https://t.co/9Bp8huqJ6M https://t.co/AD11BmoZE8

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Dr. John Cush RheumNow ( View Tweet)
COVAX Registry: Safety of COVID-19 Vaccines in Rheum Patients  https://t.co/MrywKZKcIV https://t.co/QgajVPdesg

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Dr. John Cush RheumNow ( View Tweet)
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