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Arthritis Increased Amongst US Veterans
CDC
A recent CDC reports estimates that in 2019–2021, 21% of U.S. adults (53.2 million) have physician diagnosed arthritis. Now, an updated report shows a larger number (~33%) of U.S. veterans having diagnosed arthritis. Compared to nonveterans, this prevalence was double in men, and 60% higher in women.
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Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty
A study of nearly 80,000 US veterans who underwent primary knee joint arthroplasty (TKA) showed the incidence of prosthetic joint infection (PJI) was highest in the first 3 months and remained elevated through 12 months compared with 12 months or more after surgery.
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Pain sensitization in #OA in the MOST study. Biomechanical forces- ground reaction forces may
Alter nociceptive signaling but was not associated with pain.
Walking evoked knee pain specifically tested - no diff @RheumNow #ACR23 https://t.co/G7TXuwJ2EQ
Bella Mehta bella_mehta ( View Tweet)
Development of New classification crieteria to target patients earlier in thier #OA disease course!
One tatget molecule will not solve this heterogeneous disease! @rheumnow #ACR23 https://t.co/waynA6RdUg
Bella Mehta bella_mehta ( View Tweet)
Erosive hand #OA may be more painful than treated #RA patients. The burden of OA is often not alked about, and this study highlights it! @RheumNow #ACR23 https://t.co/jLbvtMmgE0
Bella Mehta bella_mehta ( View Tweet)
Synovitis in hand #OA
genetic
risk of synovitis predisposed to clinical and radiographic hand OA
@RheumNow #ACR23 https://t.co/aXnXD7UPnv
Bella Mehta bella_mehta ( View Tweet)
What do we know about IL1 drugs in #OA only a small few stidies prior to CANTOS .
COLCHCINE didnt seem to work
LoDoCO2 post hoc analysis may work? @RheumNow #ACR23 https://t.co/h4oVRppI5S
Bella Mehta bella_mehta ( View Tweet)
Pain experience in #OA may have different contributing factors
Its a while joint disease!
What are the future targets in #OA being tested? @RheumNow #ACR23 @Tuhina_Neogi https://t.co/lI06pJrdYR
Bella Mehta bella_mehta ( View Tweet)
Physical therapy and lifestyle counseling the main pillars of #OA management are underutilized!
Mainstay remains weight loss and exercise! @RheumNow #ACR23
Rrf memorial lecture @Tuhina_Neogi https://t.co/yXqWIEccq4
Bella Mehta bella_mehta ( View Tweet)
K-drama!
Korean database noted smokers and ex-smokers had less OA fewer TKR! These were age, comorbidities matched. Unclear what the data is for sex difference or occupation. Other pubs in the past noted similar observations. Abst#1808 @rheumnow #ACR23 @UnaMakris https://t.co/ZkjWoxD8wD
TheDaoIndex KDAO2011 ( View Tweet)
Extended-Release Fluticasone Propionate for Injectable Suspension - EP-104IAR
Phase 2 Randomized (1:1), Double-blind, Vehicle-Controlled Trial
318 pts, 57% F, age 64,
Clinically and statistically significant pain relief for 14 weeks compared to vehicle
@RheumNow #ACR23 #abstL04
Bella Mehta bella_mehta ( View Tweet)
OA and Microbiome!
Ab#1581 @RheumNow #ACR23
Microbiome transplantation of mouse models - benefit if before or soon after OA induction (meniscal destabilization)
⭐️OA is inflammatory dis of innate immune sys, not "wear-and-tear" and gut biome may be a 🔑 https://t.co/eA8unUBnpC
Eric Dein ( View Tweet)
🔥 Absolute masterclass @philseo in the Clinical Year in Review #ACR23
➡️ Certain subpopulations have lower risk of AE with Tofacitinib
➡️ Knee OA 📈 75% by 2050
➡️ Exciting novel approaches in Rx of IA in development
➡️Better clinical trial endpoints needed for SLE https://t.co/5cjbZLPsCM
Caoilfhionn Connolly ( View Tweet)
Revisiting question in #painful #knee #osteoarthritis Which #steroid to inject - esp with #triamcinolone #hexacetonide shortages which is superior to #acetonide. New extended release #fluticasome #propionate > #placebo ? Is how about vs IA steroids LB04 @RheumNow @ACRheum #ACR23 https://t.co/qJazwihSe0
Janet Pope ( View Tweet)
#obesity is a significant RF for #osteoarthritis
Assoc'd with:
💠impairment of gut biota
💠microbial translocation
Leads to innate immune activation
#ACR23 @RheumNow @rheumarhyme https://t.co/iuEvBh3A1j
sheila ( View Tweet)
Different plant products
We need more RCTs
Cohort studies have a lot of attrition
Survey data shows increased utilization
#ACR23 @RheumNow https://t.co/H2pOEJ99Qh
Bella Mehta bella_mehta ( View Tweet)
Mic drop moments in #OA research by David Walsh! Focus on the bone- subchondral bone main be the PAIN POINT. @rheumnow #ACR23 https://t.co/PxCQ68YsTx
Bella Mehta bella_mehta ( View Tweet)
Subchondral bone lesions in #OA on the weight bearing regions are the source of pain - David Walsh excellent talk summarizing pain mechanisms. #ACR23 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
OA and Syncope
OA patient on NSAIDs presents with a peptic ulcer and GI Bleed.
https://t.co/ezMbqgAB0Q https://t.co/iutdfUAPv2
Dr. John Cush RheumNow ( View Tweet)
JAMA Review of Knee Pain:
- 5% PCP visits for knee pain:
- Knee #OA: 654 mill worldwide, mostly >45 yrs age
- Patellofemoral OA: < 40 yrs age; Sx: ant knee pain w/ squat
- Meniscal tears: 12% adults < 40 yrs; dx by McMurray test & joint line tenderness
https://t.co/AKVFXjY0D8 https://t.co/GpBxA2rdLP
Dr. John Cush RheumNow ( View Tweet)
