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#ACR21 Abst#0293
RA patients with lung disease have increased rates of SSc-specific autoantibodies compared to RA w/o lung disease.
▶️ Suggests we may need to investigate further into overlap phenotype in RA-ILD
@Rheumnow https://t.co/04FFuBUKmA https://t.co/A83kaie2gr
Links:
Eric Dein ericdeinmd ( View Tweet)
#Flu vaccine coverage remains low in patients with #rheumatoidarthritis.
Results from @earlyarthritis Abs#0141
https://t.co/DoZl5xyq2Q
How can we increase vaccine uptake in our patients?
@RheumNow https://t.co/nldA63EcVW
Mrinalini Dey DrMiniDey ( View Tweet)
Dr O'Brien on co-existent AAV and RA. Not something I'm used to seeing, but maybe we need to think about it more? 25 cases with RA+AAV, 52 with RA + ANCA but no AAV, not sure what the denominator is here though. Abstr#0428 #ACR21 @RheumNow @profgayecunnane https://t.co/fN3BRpc7UJ
Richard Conway RichardPAConway ( View Tweet)
🔥 Ready for the next level of imaging? The radio-labelled tracer binding to integrin αvβ3 99mTc-maraciclatide is able to detect hypervascularization in RA joints and correlates w/ PDUS findings
⭐️ Sens 78%
⭐️ See 91%
Fancy, yet more invasive than US! #Abst0174 @RheumNow #ACR21 https://t.co/eCOxjJsERh
Aurelie Najm AurelieRheumo ( View Tweet)
Dr Adachi presents ⬆️BMD gain with denosumab than risedronate in RA. Non-significant reduction in fractures (very small numbers) Interesting, but need to see fracture benefit in larger study to justify dmab as first line Abstr#0445 #ACR21 @RheumNow https://t.co/GgaS9JZGzb
Richard Conway RichardPAConway ( View Tweet)
What's the added value of MRI in diagnosing #rheumatoidarthritis among pts w/ undiff'd arthritis?
Accdg to this study by N. Hollander et al, Tenosynovitis was independently assoc'd w/ RA development esp. among ACPA- UA pts 👇
@RheumNow #ACR21 abs0155 https://t.co/F6xlZ1Hy7u
sheila RHEUMarampa ( View Tweet)
Don't forget to discuss Influenza vaccination w/ your RA patients! Higher concerns about RA medications and low necessity of vaccination beliefs associated with a ⬇️ likelihood of vaccination and suboptimal vaccine coverage.
#ACR21 @RheumNow #Abst0141 https://t.co/c5GthZxh3n https://t.co/4Nt92CHFzV
Aurelie Najm AurelieRheumo ( View Tweet)
#ACR21 Abst#0289: Predictive score for preclinical RA-ILD based on 4 identified RF:
⭐︎ ⚦ sex (OR 3.9)
⭐︎ MUC5B T-risk allele (OR 3.7)
⭐︎ mean DAS-28 (OR 2.0)
⭐︎ older age at RA onset (1.1)
Obtain HRCT if w/ above (Se ~87%)!
#ACRBest @Rheumnow https://t.co/KKRkQVY2pf https://t.co/wifiTi6vPq
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
How can we tell whether a patient already on rituximab will have an immunogenic response to Pfizer COVID-19 vaccination?
Better chance of response if:
- RA or SLE, not AAV or IIM
- high serum IgG pre-last RTX
- longer time since last RTX
Israeli data #ACR21 ABST0437 @RheumNow https://t.co/yyuFd0eDH6
David Liew drdavidliew ( View Tweet)
Dr McDermott @jeffsparks on risk factors for RA-bronchiectasis. Seropositivity, older age at RA onset, and lower BMI⬆️risk. Abstr#0288 #ACR21 @RheumNow https://t.co/7d2ZVWLzn6
Richard Conway RichardPAConway ( View Tweet)
#ACR21 Abst#0170:
↑ epicardial adipose tissue volume predicts new coronary plaque development in the following RA patients:
⋆ <10 yrs dz (OR 5.75)
⋆ 1 cardiac risk (OR 3.4)
⋆ statin < 1 yr (OR 3.3)
⋆ w/o calcification at b/l (OR 2.65)
@Rheumnow
https://t.co/tnyWRVSger https://t.co/uhak4kdbll
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Interesting study on 5yr CV event risk in early #rheumatoidarthritis pts who received T2T mgt shows no difference in CVE risk in ERA grp vs control
ERA cohort:
> Longer remission = protective for CVE
> ⬆ HAQ = predictive of CVE
Tighter control, ⬇ CVEs
@RheumNow #ACR21 abs0282 https://t.co/GG7HPvWd0r
sheila RHEUMarampa ( View Tweet)
Dr. Chambers review @MotherToBaby prospective data on HCQ use in pregnancy (n=279):
👉no major defects (regardless of dose)
👉no oral clefts
👉SGA slightly lower in exposed group b/c of underlying dz
👉no case of retinopathy in babies after 1 year f/u @rheumnow #Pregnancy https://t.co/vw2eryFgro
TheDaoIndex KDAO2011 ( View Tweet)
Abst#271 #ACR21. RA activity predicts left ventricular mass change in pts without CVD
⭐️35% had abnormal LV geometry at baseline TTE
⭐️55% at f/u TTE 3-6 years later
⭐️Increase in concentric remodeling on LV
@Rheumnow https://t.co/uHnqITcTy9 https://t.co/KmV8volVwd
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Abst#0276:
Pulse pressure (PP) = Systolic BP - Diastolic BP, measures arterial compliance
⭐️RA: higher PP than controls
⭐️PP was independent risk factor for subclinical atherosclerosis
▶️ Look at the vitals, we have this at every pt visit!
@Rheumnow https://t.co/KZaf1AwO6Q https://t.co/kN4xGxWiV9
Links:
Eric Dein ericdeinmd ( View Tweet)
It's what's below the surface that's most scary.
see: RA & the heart
- why do RA pts without cardiovasc dx/Sx get LV remodelling over time
- why is it worse with worse RA control?
RA goes deeper than the joints & our pts need to hear that!
@Columbia #ACR21 ABST0272 @RheumNow https://t.co/NDHLZwoEjy
David Liew drdavidliew ( View Tweet)
Despite >20y of bDMARDs, our patients still have a 50% greater risk of cardiovascular issues
(similar to family history or abdominal obesity)
Cardiovascular disease in RA is not historic, it's today's reality we too often ignore.
2020 data @VUamsterdam #ACR21 ABST0286 @RheumNow https://t.co/Az4wHNUOGe
David Liew drdavidliew ( View Tweet)
#ACR21 Abst#0284. RA and Dementia?
⭐️1366 pts with RA, retro pop-based cohort
⭐️Risks: older age, diabetes, CVD.
⭐️Large joint swelling swelling HR 2.2 (1.2-3.9). No significance by RF/CCP/ESR/erosions/nodules
▶️CVD risks appear > RA activity
https://t.co/2uN2lBs4tr @Rheumnow https://t.co/HEOXPosE5Z
Links:
Eric Dein ericdeinmd ( View Tweet)
Diabetes puts you at risk of cardiovascular disease, right?
What about RA?
Look at this graph and compare the pair.
"already it was impossible to say which was which” - George Orwell, Animal Farm
#ACR21 ABST0287 @RheumNow https://t.co/r0yaeC530l https://t.co/mKJhoyJ2Cn
David Liew drdavidliew ( View Tweet)
Study by @BethIWallace @Tuhina_Neogi shows that we seem to treat fibromyalgia symptoms with steroids in RA patients. Its a bad idea in fibromyalgia, and has got to be bad practice in RA too. Abstr#0120 #ACR21 @RheumNow
Richard Conway RichardPAConway ( View Tweet)
