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Autoimmune disease and pregnancy
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EurekAlert!
For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.
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Leaving Academia (2.2.24)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week we discuss hipsters undergoing hip replacement, pregnancy outcomes in RA and the future of academic clinicians.
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SeXXist Reason for More Women with Autoimmune Disease
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EurekAlert!
Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.
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Korean Database study of 1796 #AS pf (vs 7184 controls 1:4 ratio); 9.3% develeoped cancer; AS pts have no overall increase in cancer risk (aHR 1.1); AS pts had higher risk ofupper GI cancer (HR: 1.51) & hematologic CA (aHR: 2.36). Is there an NSAID effect? https://t.co/6W68upVQrn https://t.co/RWlhLFV9EJ
Dr. John Cush RheumNow ( View Tweet)
Telemedicine in MSK - systematic review of 35 studies (2015-22); 69% of low quality. Most found telemedicine to be equal or better by PROMs (vs F2F care). All showed notably lower costs for telemedicine compared to in-person visits. https://t.co/eA8QEzhJGZ https://t.co/h65WMDXjQN
Dr. John Cush RheumNow ( View Tweet)
Since April 2017, DEA Take Back (drugs) campaign has spread to 17,000 locations where your patients can safely dispose of narcotics or unsafe drugs. Find your Everyday Drop-Off center by clicking here: https://t.co/uZPtFtXk6a https://t.co/dRalITYyfV
Links:
Dr. John Cush RheumNow ( View Tweet)
No evidence of harm starting urate lowering Tx (ULT) during #gout attack. Metanalysis 6 RCTs (445 pts) w/ gout attacks given ULT vs PBO or delayed ULT. No differences in pain, time to resolve gout flare or risk of recurrent gout flare in 30d (RR 1.06) https://t.co/Zk6OjJ8I2F https://t.co/prBQeSYH2Y
Dr. John Cush RheumNow ( View Tweet)
Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/Nny9HSD5zX https://t.co/2Dnhrjz8ud
Dr. John Cush RheumNow ( View Tweet)
240 consecutive estab. RA pts underwent cervical spine X-rays looking for ant. atlantoaxial subluxation (aAAS >3 mm); aAAS found in 25 (10.4%) mean interval =4.2mm. One-third had no neck pain. aAAS predicted by lower BMI, CCP, erosions & joint prostheses https://t.co/VTMdv6wudB https://t.co/RDbjjuJAjD
Dr. John Cush RheumNow ( View Tweet)
Full read, great review of JAK/STAT signaling and JAK inhibitors published in Ann Rheum Dis.-- Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story (Authored by JAK mavens) https://t.co/xen1Htkv2o https://t.co/5hX9hhuK77
Dr. John Cush RheumNow ( View Tweet)
2022 EULAR Recommendations on Screening & Prophylaxis for Opportunistic Infections
https://t.co/5SxqsK4mSA https://t.co/2tfFRGiJcJ
Dr. John Cush RheumNow ( View Tweet)
Greek study finds 251/1264 #RA pts (20%) had difficult to treat RA (D2T). D2T Predictors were Younger age, fibromyalgia, OA, no change in DAS28-ESR in 1st 6mos b/ts-DMARD Rx. Mental-/pain-/metabolic-Dz contributed to LT worsening https://t.co/A5bfth79L2 https://t.co/f5AOvFW9Yu
Dr. John Cush RheumNow ( View Tweet)
Microbiome study of 16 SLE pts (44 fecal samples) shows that blooms of Ruminococcus gnavus pathobiont was assoc w/ lupus flares and may be the drivers of clinical of relapsing lupus disease https://t.co/Sj3dLesZpL https://t.co/7cu0X7jPM9
Dr. John Cush RheumNow ( View Tweet)
Great interview and discussion of leadership; featuring Dr. Jack Cush and Amanda Mixon, PA-C from RhAPP
https://t.co/ZjSIBmfF12
Links:
Dr. John Cush RheumNow ( View Tweet)
Now in the RheumNow poster hall:
JAKi safety and efficacy in bDMARD-IR patients with RA. Results from a long-
term extension through Week 204. Sponsored by AbbVie US Medical Affairs.
https://t.co/eoSFQMXmQk https://t.co/DFuC8kOGQp
Dr. John Cush RheumNow ( View Tweet)
One-Third of Physicians Intend to Leave Academia
A cross-sectional survey of academic physicians shows that approximately one-third intend to leave their institutions in the next two years.
https://t.co/Bugkjg9r9q https://t.co/PjPJi8TICz
Dr. John Cush RheumNow ( View Tweet)
Aging Brain Increases Pain in Older Women
https://t.co/450fwH4zQr https://t.co/dttRc4HgYC
Dr. John Cush RheumNow ( View Tweet)
Outcomes of Acute, Subacute and Persistent Low Back Pain
Low back pain is a major cause of disability around the globe, with more than 570 million people affected.
https://t.co/aIR110aEr0 https://t.co/tKPp0Un68H
Dr. John Cush RheumNow ( View Tweet)
Is non-alcoholic fatty liver dz assoc w/ osteoarthritis? Study of 2633 pts - 317 (12.8%) w/ OA& 1140 NAFLD(41.5%); NAFLD was positively correlated with OA (OR = 1.72; 1.26–2.34). https://t.co/whWX2XIu3d https://t.co/sGXQYSFcH3
Dr. John Cush RheumNow ( View Tweet)
Wed. Jan 31st was Dr. Janet Woodcock’s last day at the US Food and Drug Administration (FDA), capping a remarkable 38-year career. A rheumatologist, Dr. Woodcock She’s has been one of the most powerful and influential drug regulators worldwide. THANKS JW! https://t.co/vVUGaknYmM https://t.co/9pV7QYH0zm
Dr. John Cush RheumNow ( View Tweet)