Cardiovascular Risk in Cutaneous Lupus Erythematosus Save
A retrospective study of cutaneous lupus erythematosus (CLE) patients finds an increased risk of atherosclerotic cardiovascular disease (ASCVD) on par with systemic lupus patients.
An IBM MarketScan Commercial Claims data analysis from 2018 to 2020 included patients with CLE, SLE, and psoriasis, matched 10:1 with the CLE population on age, sex, insurance type, and enrollment duration. THe primary outcome of ASCVD defined as coronary artery disease, prior myocardial infarction, or cerebrovascular accident.
The cohorts included 8138 CLE (median age 49 years; 81% female), 24 675 SLE (median age 46 years; 91% female), 192 577 psoriasis (median age 48 years; 55% female), and 81 380 controls (49 years; 81% female). In multivariate analysis, ASCVD risk was higher CLE (odds ratio 1.72 [95% CI, 1.45-2.02]; P < .001) and SLE (OR, 2.41 [95% CI, 2.14-2.70]; P < .001) compared to controls.
When followed for a median of 3 years incidence rates of ASCVD were
- SLE 24.8 per 1000 person-years
- CLE 15.2 per 1000 person-years)
- psoriasis 14.0 per 1000 person-years
- controls 10.3 per 1000 person-years
In this retrospective matched longitudinal cohort study, CLE was associated with an increased risk for ASCVD, similar to the risk in SLE but higher than the risk in psoriasis.
ADD THE FIRST COMMENT
Disclosures
The author has no conflicts of interest to disclose related to this subject
If you are a health practitioner, you may Login/Register to comment.
Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.