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Heritability of Osteoarthritis
A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.
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New Year's Resolutions (1.5.2024)
Dr. Jack Cush imparts his new New Year's Resolutions for 2024 and also reviews the news and journal reports from the past week on RheumNow.com.
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Life expectancy in RA? Taiwan insurance claims data shows life expectancy after an RA Dx was 26.3 yrs, w/ mean loss of 5 yrs. Women lived 1–2 yrs longer than men. https://t.co/Z5PqWZX94V https://t.co/RKZNDxPUd3
Dr. John Cush RheumNow ( View Tweet)
QD Clinic - A Non-Textbook Patient
Widespread pain and a swollen wrist
https://t.co/OixGhsKHRQ https://t.co/lvZ0duYwxw
Dr. John Cush RheumNow ( View Tweet)
Curcumin therapy for knee osteoarthritis
Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly KOA.
https://t.co/0EmPrEZTce https://t.co/74uNQJ3a34
Dr. John Cush RheumNow ( View Tweet)
Enthesitis, Synovitis, and Tenosynovitis in Psoriatic Arthritis
An ultrasound study suggests that enthesitis is associated with both synovitis and tenosynovitis in patients with Psoriatic arthritis (PsA).
https://t.co/fsVlUwOXCW https://t.co/1tLTlEoXd8
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Experience the Future of Rheumatology at RheumNow Live 2024, just three weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/HN8ErCpSMb https://t.co/kCYD7Hbhxx
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Hydroxychloroquine for COVID may have caused 16,990 deaths. Systematic review of 44 cohort studies showed HCQ use in COVID was associated with 11% increase in mortality in 6 countries (US 12,739, Spain 1,895, Italy 1,822, Belgium 240, France 199,Turkey 95 https://t.co/vmhvSx4XLO https://t.co/KRxqiiSFC3
Dr. John Cush RheumNow ( View Tweet)
There is a dose, duration and recency-dependent relationship between previous GC use and MACE. GC doses 5mg/day, durations of 30 days, and use one year prior to MACE were all associated with an increased risk of MACE, Wallace B Abst#2430 #ACR23 #ACRBest https://t.co/VOUmsvAs2r https://t.co/LKtuuoD3xa
Dr. John Cush RheumNow ( View Tweet)
Biomarker Predicts Survival in Autoimmune Lung Disease
One major subgroup of patients with ILD arising from polymyositis/dermatomyositis (PM/DM) survived significantly longer when serum levels of interferon-λ3 were relatively low, researchers found.
https://t.co/2nYPBbNfCh https://t.co/n2Llxb7tdx
Dr. John Cush RheumNow ( View Tweet)
Small study of 33 #AAV pts and 21 controls shows nailfold capillaroscopy of no value in diagnosing/assessing AAV pts. https://t.co/QbNCJZLoix https://t.co/9xkFPE0noV
Dr. John Cush RheumNow ( View Tweet)
Anti-TNF mAbs, JAKi & anti-IL17 Rx appear protective against anterior Uveitis in AxSpA pts. Network Metanalysis of 44 trials, AU IR -TNF mAb: 4.1, ETN: 5.4, IL17i: 2.8, JAKi: 1.5, & placebo: 10.8. AU risk: TNFi < JAKi < IL-17i < ETN << PBO https://t.co/3zIcvuIaBV https://t.co/UseZ6t00EB
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Congratulations to Professor Paul Emery OBE on being named CBE: Commander of the Most Excellent Order of the British Empire for his research and advances in rheumatology. He is the Versus Arthritis Professor of Rheumatology, Leeds Institute https://t.co/27igYiQxna https://t.co/KcQk5LasfN
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AutoAbs in poly/dermatomyositis - ANA+ 50% to 80%, but not helpful in Dx. Look for MSA Abs - espec antisynthetase ABs (anti-Jo-1), but also newer Abs: MDA-5, TIFF-1 gamma, NXP-2 (to be discussed #RNL24 Dr. Christopher-Stine) https://t.co/ZRlMPE48qX https://t.co/kxD1jw832C https://t.co/afC617tbmq
Dr. John Cush RheumNow ( View Tweet)
Sarcopenia Linked to Smoking in Osteoarthritis
Sarcopenia commonly has been linked to aging and arthritis and contributes significantly to quality of life and outcomes, but the association between sarcopenia and OA has not been well established.
https://t.co/anZMTGnFej https://t.co/TgVg3xpiWI
Dr. John Cush RheumNow ( View Tweet)
Biomarker Predicts Survival in Autoimmune Lung Disease
One major subgroup of patients with ILD arising from polymyositis/dermatomyositis (PM/DM) survived significantly longer when serum levels of interferon-λ3 were relatively low, researchers found.
https://t.co/PcTmzavJuC https://t.co/cNL3iTSGiF
Dr. John Cush RheumNow ( View Tweet)
Sarcopenia Linked to Smoking in Osteoarthritis
Sarcopenia commonly has been linked to aging and arthritis and contributes significantly to quality of life and outcomes, but the association between sarcopenia and OA has not been well established.
https://t.co/ucEWJjZ8Zv https://t.co/MeHw56vLjj
Dr. John Cush RheumNow ( View Tweet)
GNSC-001 gene therapy w/ a recombinant adeno-assoc. viral vector expressing IL-1Ra, to block IL-1. GNSC-001 now in a phase Ib, 50 pt, 10 center USA trial to assess its efficacy in Knee OA. Given as single injx in the affected joint; results in late 2024 https://t.co/jW9FHlGyC2 https://t.co/Dbv15Flqlv
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Dr. John J Cush RheumNow ( View Tweet)
Cross-sectional study of 307 RA pts, 49 (16%) used psychotropic meds and 70 (23%) had at least one fall per year. RA on psychotropic meds had double the rate of falls (39% vs 20%). w/ an adjusted incidence rate ratio, 1.63. (p = 0.02). https://t.co/D1lhZj3he3
Dr. John Cush RheumNow ( View Tweet)
New download on ChatGPT available!
https://t.co/mZc5Ex2vU9 https://t.co/DyfZepwFOD
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Dr. John Cush RheumNow ( View Tweet)