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Unique Oral Microbiome in Early and Pre-Clinical RA

Jack Cush, MD

An oral microbiome study of rheumatoid arthritis patients suggests that periodontal condition in patients with early rheumatoid arthritis and individuals at risk of RA.

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Step, down, arrow, blocks

ARTIC REWIND - Don't Half DMARD Therapy

Jack Cush, MD

The ARTIC-REWIND study examined rheumatoid arthritis (RA) patients in remission on conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) to see if they could "step-down" their csDMARDs theray; but  the study showed that 25% those who went on half-dose experienced disease fl

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Level, monitor, calculate, glucose, diabetes

Drug Monitoring Ineffective with Infliximab Treatment

Jack Cush, MD

The predictive value of therapeutic drug monitoring (TDM) while on biologics is debateable; gastroenterology routinely relies on TDM, while rheumatologists do not.

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RheumNow Podcast – Uppers and Downers

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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AE, Side effects

Predictors of Methotrexate Toxicity

Jack Cush, MD

A metanalysis showed that while adverse events (AEs) are common when methotrexate is used in rheumatoid arthritis or inflammatory arthritis patients, serious AEs ranged from 2.1 to 9.5% and drug discontinuations ranged from 6.7% to 15.5%, mostly due to gastrointestinal events. 

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RheumNow Podcast – Coconspirators: RA and Lung Disease

Jack Cush, MD

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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MS, multiple, sclerosis, demyelinating, brain, plaque

BSRBR: Demyelinating Disease Following Anti-TNFα Therapy

Jack Cush, MD

Analysis of patients receiving anti–tumor necrosis factor α (TNFi) therapy in the British Society for Rheumatology Biologics Register (BSRBR) shows that the risk of demyelination is rare but is marginally increased by taking TNFi therapy. 

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Increased Risk of COPD in ACPA+ Pre-RA Patients

Jack Cush, MD

The lung and its pathology is uniquely tied to rheumatoid arthritis (RA) and its pathogenesis.  A new study shows that elevation of anti–citrullinated protein antibodies (ACPAs) before diagnosis of RA increases the risk of developing chronic obstructive pulmonary disease (COPD

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NICE Guidelines on Chronic Pain Management

Jack Cush, MD

In the United Kingdom, where it is estimated that chronic pain affects one‑third to one‑half of the population, NICE (National Institute for Health and Care Excellence) has recently released an updated guideline on the management of chronic pain for people aged 16 years and over.

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New download available! Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM https://t.co/3f8sRSgyQo

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Dr. John Cush RheumNow ( View Tweet)
Real world comparision of baricitinib (n 138) and tofacitinib (n 156) in #RA patients shows at wk 24, BARI out performed TOFA - CDAI remission (40.4 vs 28.3%) and CDAI LDA (81.6 vs 69.3%); safety signals were equal between groups. https://t.co/0quNNGB18K

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Dr. John Cush RheumNow ( View Tweet)

Coconspirators: RA and Lung Disease Download this week's RheumNow podcast, where Dr. Cush reviews the news and journal articles for the last week. https://t.co/MJbfJANWwt https://t.co/PUqewOvBjZ

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Dr. John Cush RheumNow ( View Tweet)
Diary study of 79 FM, 86 RA, 33 w/ both FM/RA shows that compared to RA, pts with FM have worse daily well-being, negative affect, more isolation, inability to complete plan. FM had more perceived stigma and lower well-being. https://t.co/YZdhvYghuI

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Increased Risk of COPD in ACPA+ Pre-RA Patients A new study shows that elevation of ACPAs before diagnosis of RA increases the risk of developing COPD and/or asthma. https://t.co/1F8fOxpaQ0 https://t.co/GaaGcF90YD

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Dr. John Cush RheumNow ( View Tweet)
37 RA, 28 PsA & 20 AS pts in remission/LDA x 6 mos enrolled in DMARD spacing. Joint flares seen in 13.5% RA, 21.4% PsA & 20% axSpA pts but 5 more PsA patients had skin flare. PsA had lower persistence 61% (vs RA 87% & 80% AS) due to skin flares https://t.co/d1rMLTXSQs https://t.co/fNNSofWxgv

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Dr. John Cush RheumNow ( View Tweet)
Dual seropositivity with RF/ACPA autoantibody higher titers were strongly associated with prevalent RA-ILD (OR 2.90; developed in 3.7%). ILD more likely with high titer RF (HR 3.4) than high titer CCP (HR 1.9). https://t.co/ebvJjatQSw

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Dr. John Cush RheumNow ( View Tweet)

ASSAIL-MI trial studied 200 pt with new (<6hr) STEMI-randomized to either PBO or IV 280 mg tocilizumab. While no signif difference in final infarct size (7.2 vs 9.1%; P=.08), TCZ treated pts had better myocardial salvage & less Microvascular obstruction https://t.co/WRRGXCbP5O

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Dr. John Cush RheumNow ( View Tweet)

Smoking and RA are closely related. 50% of establish RA pts higher rate of smoking Smoking cessation - lowers RA disease activity #RNL2021

Dr. John Cush RheumNow ( View Tweet)

Can Multiple Sclerosis and RA Coexist? What Drugs can be used? https://t.co/PYFQI7vn3M https://t.co/UQplGREDjf

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Dr. John Cush RheumNow ( View Tweet)
Coverage from Dr. Robert Chao ( @doctorRBC) from #RNL2021 #RheumNow "How do you treat RA pts with persistent pain? Dr. Alan Matsumoto - “We have to understand that there may be other pathways of pain besides inflammatory”

Dr. John Cush RheumNow ( View Tweet)

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