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Panel discussion online and in person on #rheumatoidarthritis #RNL2024 Dr. Weber discusses with Dr. Guma, Dr. Gabalawy and @rheumnow ways to assess CV risk in patients by looking at family history, inflammation, comorbidities, imaging studies https://t.co/yM58kvr7CR
TheDaoIndex KDAO2011 ( View Tweet)
Happening Now! RheumNowLive @RheumNow
Stil time to register and join; only $105 for fellows!
Clinically focused & high yield; check it out! https://t.co/ADTEbsJrxP
Mike Putman EBRheum ( View Tweet)
How do you communicate risk/benefit to patients? @RADoctor's recent publication highlighted by Dr. H. Gabalawy at #RNL2024 @RheumNow
1. Increase awareness
2. Include numbers for context
3. Make it easy for patients to understand those numbers
4. Use absolute risks
5. Avoid 1 in… https://t.co/DqmgD2j5Wp https://t.co/v6CQAX9YRr
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Managing patients with clinically suspect arthritis (CSA), <20% of ACPA positive patients without arthralgia develop RA in 5 years, Hani El Gabalwy #RNL2024 @RheumNow https://t.co/RKaDsozhXl
Dr. Antoni Chan synovialjoints ( View Tweet)
Per this study: 40% of pts had RA at 5 years and 40% were seronegative at 5 years. (See red line box) Interesting finding from Dr. H. Gabalawy #RNL2024 @RheumNow https://t.co/m5zJkDO2bk
Dr. Rachel Tate uptoTate ( View Tweet)
“Less than 20% of low +CCP patients who are asymptomatic will develop RA over 5 years” – Dr. Gabalawy recommends lifestyle changes (STOP smoking, Mediterranean diet, exercise) ; a substantial proportion will revert to ACPA neg state #RNL2024 @RheumNow https://t.co/yyHwVZWOf0
Links:
TheDaoIndex KDAO2011 ( View Tweet)
Why should we care about preclinical RA? Goal: to treat once and stop the trajectory of the disease. – Dr. Gabalawy #RNL2024 @rheumnow https://t.co/afbpvrZV8v
TheDaoIndex KDAO2011 ( View Tweet)
<20% of anti-CCP+ pts without arthralgia with develop RA in 5 years!
Dr. H. Gabalawy
#RNL2024 @RheumNow https://t.co/OXe7EWfCmc
Dr. Rachel Tate uptoTate ( View Tweet)
#RNL2024 @RheumNow
TREAT-EARLIER - MTX for Clinically Suspect Arthralgias
No overall diff vs PBO
High risk pts had benefit, but not sustained at 2 yrs
But sustained reduction in HAQ & MRI inflammation
- Signs for hope? Overall, prevention studies have been disappointing https://t.co/DtBlGaw0Lf
Links:
Eric Dein ericdeinmd ( View Tweet)
Rheums are "all over the map" but tend to skew conservatively when treating pre-clinical RA.
Dr. H Gabalawy discusses the results of a case-driven polling question at #RNL2024 @RheumNow.
Be sure to register at https://t.co/DXQ0KCelIh to hear his, and other, lectures to weigh… https://t.co/Yo3ChNwNIO https://t.co/wD3AMUDNr9
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
“At 2 years, 50% of patient with +RF/+CCP Ab will develop RA, at 5 years, 70%” – Dr. Gabalawy on can we predict who will get RA, is there a point of no return, can we prevent the progression #RNL2024 @rheumnow https://t.co/G8Rxd3CAoi
Links:
TheDaoIndex KDAO2011 ( View Tweet)
Seropositive RA is a spectrum to disease
Hani El Gabalawy @RheumNow #RNL2024
Genetic and environmental factors affecting autoimmunity and leading to disease
Clinical suspect arthralgias usually finds "imminent RA", may be too late at that stage for prevention https://t.co/mGclCr3cth
Links:
Eric Dein ericdeinmd ( View Tweet)
Dr. Hani Gabalawy shared his pre-clinical stages of seropositive RA
--Break in the immune tolerance > pathogenic autoimmunity > RA
Unknowns: timeline, can we arrest pre-clinical stages, etc?
#RNL2024 @RheumNow https://t.co/8cMNGKM4rk
Dr. Rachel Tate uptoTate ( View Tweet)
Using diet to shape the microbiome and to improve outcomes in inflammatory arthritis and response to medication. An anti-inflammatory and Mediterranean diet can help improve outcomes in RA, Monica Guma #RNL2024 @RheumNow https://t.co/x64Tbseuvz
Dr. Antoni Chan synovialjoints ( View Tweet)
"The gut microbiome may affect how patients respond to their therapies" - Dr. Guma another reason why diet is important #RNL2024 @rheumnow https://t.co/7qI72HWRg0
TheDaoIndex KDAO2011 ( View Tweet)
“Even a cookie changes the gut microbiota!” – Dr. Guma showing dynamic microbiota changes to the food we eat and even to the medications we take. #RNL2024 @rheumnow https://t.co/5d6Ld39BzG
TheDaoIndex KDAO2011 ( View Tweet)
Monica Guma at #RNL2024 @RheumNow
How does Mediterranean diet help inflammation?
Maintains healthy microbiota
Enhancing production of anti-inflammatory metabolites
Maintains intestinal barrier integrity https://t.co/CyzTGBJzhm
Links:
Eric Dein ericdeinmd ( View Tweet)
You are what you eat!
So how does the Mediterranean diet affect the gut?
*maintaining/shaping healthy gut microbiota
*enhancing anti-inflammatory metabolite production
*maintaining intestinal barrier integrity
Dr. M. Guma #RNL2024 @RheumNow https://t.co/O9by7CahRW
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
How does the Mediterranean diet affect inflammation? Dr. Guma noted the diet helps to:
1. maintain healthy microbiota
2. enhance production of anti-inflammatory metabolites
3. maintain intestinal barrier integrity.
#RNL2024 @rheumnow https://t.co/d3ByStvXyR
TheDaoIndex KDAO2011 ( View Tweet)
Dr. M Guma noted @ACRheum 2022 Guidelines on RA recommend the #MediterraneanDiet; studies have shown this diet reduces CV risk, RA disease activity #RNL2024 @RheumNow https://t.co/AdKWgME4nD
TheDaoIndex KDAO2011 ( View Tweet)