All News
What is #nonadherence in #SLE associated with?
115 Pts w #lupus in Spain
Overall medication adherence 58%!
👇Reduced if
Male
Low education
No partner -NS adjusted analysis
Unemployed
Comorbidities
3 or more drugs/pills -NS adjusted
#ACR25 @RheumNow @ACRheum
#abst0216 https://t.co/CkG6gpiCw3
Janet Pope Janetbirdope ( View Tweet)
Two Jacks, One mission 🤓
Head on to the booth and get a chance to meet either one of them (both if you’re lucky, like me!)
Continue tuning in for coverage of #ACR25 by the @RheumNow faculty and KOLs https://t.co/Y2pS8CpoH5
sheila RHEUMarampa ( View Tweet)
CE study BEL vs csDMARDs in TriNetX
Mortality ~3-4% for MTX/AZA/MMF vs ~1.5% for BEL, ~50% reduction in adjusted analysis
Pretty surprising given mediocre results from BLISS RCTs, but strong research group & lotsa fancy stats
Do you believe it?
#ACR25 @RheumNow Abstr#0804 https://t.co/Yex98EYDjP
Links:
Mike Putman EBRheum ( View Tweet)
#ACR25 Abstr#802 In #SLE pts with CLASI-A ≥8, pooled post-hoc analysis of Phase 2 RCT showed enpatoran, oral small molecule toll-like receptor 7/8-i impoved cutaneous response vs PBO as early as WK4. First-in-class promising therapy & warrant investigation in Phase 3 @RheumNow https://t.co/rn6NXdiGjD
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Urinary proteomics reveals promising biomarkers for ankylosing spondylitis. PIK3IP1 & SDC1 levels were significantly elevated in AS patients, showing strong diagnostic performance (AUCs: 0.852 & 0.875). Combined with AMY1A, the multiplex panel reached an AUC of 0.973. Abstract https://t.co/YUulKFqj8V
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Effect of BioDMARDs on Diabetes risk in 6400+ Psoriasis pts
IL-23i and IL-17Ai associated w/
-lower risks of diabetes
-Diabetic nephropathy
-Stage 3–5 CKD
and reduced risk compared to TNFi treated and bionaive pts
Adjustment on several variables, but not disease severity https://t.co/TDIHXJOC2T
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
The benefits of exercise has been proven for most rheumatic diseases, and there are lots of good reasons why
#ACR25 Brian Andonian @RheumNow https://t.co/IEErXL6ynL
David Liew drdavidliew ( View Tweet)
What is my risk of developing proteinuria?
Hopkins Lupus Cohort developed a risk score predicting 10-year risk of new-onset proteinuria after SLE dx (n=1,418)
@RheumNow #ACR25 https://t.co/Z0zPrG2NJ3
Akhil Sood MD, MS AkhilSoodMD ( View Tweet)
#ACR25 Abstr#801 Post-hoc analysis of Phase 2 RCT showed longer duration on Ianalumab (IAN) is beneficial. More #SLE pts achieved LLDAS or DORIS remission and GC taper in IAN in blinded 28-wk phase + open label IAN for the next 24-week group vs PBO-Open Label IAN @RheumNow https://t.co/I1Ugfj3BBl
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
A retrospective study from Spain assessed the relationship bet HPV infxn & biologic tx in SLE pts
đź”… Prevalence of HPV 9.9%
đź”… No significant assocs bet HPV infxn, biologic tx, SLE-related dse variables & HPV RF progression
Still, emphasize HPV screening
#ACR25 @RheumNow Abs0659 https://t.co/1YusM1nYPr
sheila RHEUMarampa ( View Tweet)
#0777 Big news for VEXAS! 🎯
The first validated disease activity index (VEXAS-DAI) has been developed via international Delphi consensus. A 12-domain, 40-point tool to standardise assessment & power trials in this complex syndrome. Validation underway! @RheumNow #ACR25 https://t.co/DSeHb7eNeV
Mrinalini Dey DrMiniDey ( View Tweet)
Redefining When to Biopsy the Kidney in Patients with SLE # Petri et al. ACR 2025 - Lupus nephritis may be seen in lower proteinuria too (69%)
Happy to share similar results from our study-Padiyar S, As C, Gowri M, Mathew J. Lupus. 2024;33(13):1511-1517.
@RheumNow
Dr Shivraj Padiyar DrPadiyar ( View Tweet)
New biomarkers 14-3-3η multiplex autoantibody assay improves axSpA diagnosis, especially in HLA-B27– patients. Combined with CRP & HLA-B27, detection rose to 99% (training) & 91.4% (evaluation). In HLA-B27– cases, 14-3-3η lifted detection to 70.6% & 55%. Abstract 0531 @RheumNow
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
FDA Approves Obinutuzumab for Active Lupus Nephritis
The FDA has approved obinutuzumab (Gazyva) for the treatment of lupus nephritis. This is good news for the more than 1.7 million people worldwide with lupus nephritis.
https://t.co/Wr3tG5izCi https://t.co/P8A5PUCIX0
Dr. John Cush RheumNow ( View Tweet)
#Cancers esp #hematologic & #lung are ⬆️in Pts w #inflammatory #rheum #diseases
Odds ratios of hem malignancies are wide
& risk stratification is imp
Are we doing a good job?
🤔skin cancer screening ??- not as per general standards
Abst#0172 #ACR25 @RheumNow @ACRheum https://t.co/Uve9knXD3o
Links:
Janet Pope Janetbirdope ( View Tweet)
Do you believe that patients w #rheumatic #diseases flare if #extreme #weather?
Even 90 days after extreme weather events flares occur - loss of power, heat’ med storage = ++stressful events
Is it early flare from weather & then ++stress
@RheumNow @ACRrheum #ACR25 abst#0164 https://t.co/pGPwOKrKU7
Janet Pope Janetbirdope ( View Tweet)
Why do pts with #Still’s #AOSD
Get hospitalized?
#Sepsis
1827 unweighted & 9135 Weighted #US #hospitalizations
Worse in
men
Black
Medicaid
But is it truly #infection or Still’s flare or both?
Abst#0163
ACR25 @RheumNow @rheumacr
#ACRBest as largest N ever! https://t.co/fLMNyQQNNj
Janet Pope Janetbirdope ( View Tweet)
#ACR25 Beyond blinatumomab, A-319, CD3xCD19 BiTE in 12 patients with #SLE in China reported dose-dependent depth of B-Cell depletion but not efficacy or safety. One withdrew due to AE. No CRS/ICANS. Be interested to see results in larger trials & longer follow-up @RheumNow https://t.co/e5RuZlFI6i
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
In case there was any doubt:
GCA leads to ischemic vision loss
PMR does not
#ACR25 ABST0753 @RheumNow https://t.co/mCS9B4Flgl
David Liew drdavidliew ( View Tweet)
Leflunomide - a perennial question in GCA, that we still haven’t answered (as this meta-analysis shows), despite clear potential.
We are getting a clearer idea of the strengths/limitations of MTX in GCA, is it now time to get better clarity for LEF?
#ACR25 ABST0731 @RheumNow https://t.co/ycuvPx8Xdg
David Liew drdavidliew ( View Tweet)
