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ACR21 Best Abstracts - Day 1

Jack Cush, MD

The RheumNow faculty have been glued to their monitors all day, watching video, and running down abstract presentations to find the best – several of these stood out as #ACRBests. Here is a listing of “Best” they saw on Day 1.

Akhil Sood MD Tweet
AkhilSoodMD
Abstr 0579 Kim & Colleagues examined predictors of Tx change among RA patients w/ TNFi as 1st line biologic agent - Females & GC use more likely to switch agent - Vitamin D use & hx of other immune-mediated diseases (eg. Psoriasis, IBD) less likely to switch #ACR21 @RheumNow https://t.co/FM5mSWmSNA
Eric Dein Tweet
ericdeinmd
#ACR21 Abs#0825 Early RA -Rx-naive: 48 wk, csDMARD+GC vs. 3 bDMARD+MTX (CZP/ABA/TCZ) ⭐️Superiority for ABA+MTX and CZP+MTX vs. to csDMARD+GC, not in TCZ+MTX ⭐️ Radiographic progression low in all ▶️ Short study w very aggressive 1st line combo Rx https://t.co/TJPZkqmN8z @Rheumnow
Aurelie Najm Tweet
AurelieRheumo
🩸 Hb levels markers of RA activity and structural progression? Boston BRASS registry: 1500+ patients. Low hb at headline associated w/ MTX TNFi and ⬆️ increase in TSS. Not that surprising provided low Hb is a marker of systemic inflammation. #Abtr0786 #ACR21 @Rheumnow https://t.co/eQLGxsANkk
TheDaoIndex Tweet
KDAO2011
Can RA be cured? Dr. Thomas' proof of concept RA immunotherapy study: DEN-181 is a liposome immunotherapy given by SQ injx; it's presented by LN-DCs causing: CTL exhaustion while controlling autoreactive CD4+ T cells #ACRbest @rheumnow #ACR21 Abst#0967should have been a plenary! https://t.co/6ZzDgavafS
Richard Conway Tweet
RichardPAConway
@KronzerMD @jeffsparks on association of respiratory diseases with incident RA. Upper airway diseases (sinusitis, pharyngitis) seem to associate even more strongly than asthma/COPD. Abstr#564 #ACR21 @RheumNow https://t.co/HvoBOs3OOF
Richard Conway Tweet
RichardPAConway
Dr Mahajan on lung disease in early RA. Common, airway disease in 60%, parenchymal disease in 30%. But minimal/no progression over 1 year which is reassuring. Abstr#574 #ACR21 @RheumNow https://t.co/s9r06MSStF
Richard Conway Tweet
RichardPAConway
MUC5B and RA-ILD. Dr McDermott @jeffsparks show that MUC5B is associated with RA-ILD, older age at RA diagnosis, and ILD within 5 years of RA onset. Is this a different disease to other RA or modulation by the promotor variant? Abstr#0576 #ACR21 @RheumNow https://t.co/r2fQqxVY6N
Richard Conway Tweet
RichardPAConway
And here is ORAL-Surveillance, small increase in MACE and malignancy with tofacitinib vs TNFi. 1 extra MACE per 319-567 patient years, 1 extra malignancy per 275 patient years. Abstr#0831 #ACR21 @RheumNow https://t.co/wMJnspTTBy
David Liew Tweet
drdavidliew
For rheumatologists, instinct says in RA everything’s better with MTX. For tofacitinib, where immunogenicity not an issue, is that actually true? Canadian registry data: maybe no after 36m, low no. ?valid, markups mine Need to see more of this! #ACR21 ABST0827 ⁦@RheumNow⁩ https://t.co/VVwd4SZgVx
TheDaoIndex Tweet
KDAO2011
Dr. Thomas reviews risk for progression to RA 👉+ACPA (9% risk) 👉1st degree relative 3-9X risk 👉70% risk in 5 years of both are true!👈 #ACR21 @rheumnow https://t.co/y5eUyacBFT
Aurelie Najm Tweet
AurelieRheumo
An important message from Dr Ranjeny Thomas on #RA #disease control: "Patients can have a significant impact on the control of their disease, and the interventions we recommend need to be personalised to their resilience ability." #ACR21 @RheumNow https://t.co/h63uz5kfU8
David Liew Tweet
drdavidliew
Booking regular clinic visits for controlled RA pts - can we be more efficient? 12m RCT Self-monitoring app, supported self-initiated care only one scheduled follow-up visit controlled RA pts DAS28/pt satisfaction same visits/y: 1.7 vs 3.0 @reade_020 #ACR21 ABST0830 @RheumNow https://t.co/600XTKo9GM
TheDaoIndex Tweet
KDAO2011
Risks for RA: - chromosome 6 has HLA risk genes encoding HLA-I and -II - HLA-DRB1 *04:01 and *04:04 stonrgly assc w/ RA in white Americans/Europeans - the Shared epitope increase risk for RA & severe disease; high assc with ACPA+ Protective➡️HLA-DRB1*13:01 @rheumnow #ACR21 2/2
TheDaoIndex Tweet
KDAO2011
Chances for RA if a family member has RA? Dr. B Masri reviews familial studies: 👉person w/1st degree relative w/ RA has 2-4 X risk 👉Multigen study standard incidence ratios: 3.02 child, 4.64 siblings, 9.31 in multiplex family, 6.48 twins, 1.17 in spouses #ACR21 @rheumnow 1/
TheDaoIndex Tweet
KDAO2011
Dr. Ranjeny Thomas on preventing RA: 👉60% genetics/immunopathogenesis (noncontrollable factors) 👉40% lifestyle modifications: healthy diet, healthy weight, avoiding tobacco, reduce occupational exposure, improve exercise/sleep, decrease stress. #ACR21 @rheumnow 1/2 https://t.co/eoh3kcekR8
TheDaoIndex Tweet
KDAO2011
Dr. R Thomas: current studies on prevention of RA: 👉oral DMARDS (MTX, HCQ) 👉biologics (RTX, abatacept) 👉 studies regulating T cells to restore tolerance 👉biomarkers of tolerant state & look at people who don't develop RA 👉 imaging as window of subclin dz. #ACR21 @rheumnow https://t.co/5bsu5459az
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