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Mucosal Disruptions as Initiators of Rheumatoid Arthritis
Many have suggested that microbiome and mucosal disruptions are contributors to autoimmunity, especially rheumatoid arthritis (RA). This is partly represented in what is known as the "mucosal hypothesis" to RA. A current review article by Hollers, et al. addresses how distinct mucosal endotypes can serve as drivers or initiators of RA.
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Analgesic Prescribing in Patients with Inflammatory Arthritis
A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis (IA) patients has declined, but still remains substantial, including opioid prescribing.
Stop Counting Bugs (10.4.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research.
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Risk of Uveitis with Spondyloarthritis
A retrospective registry study shows that uveitis may be seen in 10% with the diagnosis of axial spondyloarthritis (axSpA) but becomes more common (47%) over the next 30 years of disease. The good news is that biologic therapy can significantly lower the risk of uveitis in (SpA).
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Genomic profiling of 34 ANCA-assoc vasculitis pts w/ glomerulonephritis suggests activity by cytokine-producing CD4+ & CD8+ T cells & potential for ustekinumab. 4 relapsing GN pts Rx w/ UST & CTX +steroids, w/ good responses, improved GFR and BVAS scores… https://t.co/ospA8CJ6JE https://t.co/HbRpXMec0f
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Postop periprosthetic femoral Fx (POPFF) post hip replacement (THR) is uncommon. POPFF needing surgery 0.92 per 1,000 prostheses years; higher in elderly (1.31) & w/ THR for hip Fx (2.19). 1% risk of POPFF w/in 10yrs of THR (15% these die w/in 1 yr) https://t.co/8u3WUWhHnU https://t.co/LfOSPpYbzw
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Korean Claims analysis of 413 radiographic axial spondyloarthritis (TNFi exposed=75 ). Recurrent CV events = 32 per 1,000 person-years; but lower if TNFi Rx'd = 19/1000PYs. TNFi exposure significantly lowered risk of recurrent CV events https://t.co/f69SHpXZCx https://t.co/ofpg0JbrR1
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Medscapes Diagnostic evaluation of inflammatory myositis patients
Labs
Imaging
EMG/NCV
Muscle Bx
https://t.co/jDNlqypoq8 https://t.co/dBgMgex4Cw
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2023 EULAR Recommendations on Management of Fatigue
A 2023 EULAR task force has made recommendations to the approach and management of fatigue in patients with inflammatory rheumatic and musculoskeletal diseases (I-RMDs).
https://t.co/0wMEa9IHcH https://t.co/I8OgefJKfy
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Korean population study shows RA was linked to a higher migraine risk, regardless of seropositivity. Comparison of 42,644 RA vs 213,370 controls - found higher risk of migraine (adj HR 1.21; 1.17–1.26). https://t.co/8jlJ4oV95Z https://t.co/r7hsQpt3u7
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Full read review of Pathogenic autoantibodies in idiopathic inflammatory myopathies: antisynthetase autoAbs, TIF1, MDA5, SRP, HMGCR, TRIM72, cN1A, FHL1, eIF3 autoantibodies and more https://t.co/uzCmauulWZ https://t.co/twhwCB4xof
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ASAS Imaging Recommendations for Suspected Spondyloarthritis
ASAS (Assessment of Spondyloarthritis International Society) has convened specialized task force to guide imaging request on patients with suspected/known axial spondyloarthritis (axSpA).
https://t.co/snSKDtToHh https://t.co/wpGSHkTwCD
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JAMA Patient Education Page - Plantar Fasciitis
Plantar Fasciitis accounts for more than 1 million US clinic visits per year. People at risk include obesity, jobs w/ prolonged standing https://t.co/BzAWmdX8gA https://t.co/bNFSSuN8Xv
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Pneumocystis Jirovecii Pneumonia Complicating Systemic Vasculitis
A retrospecitive analysis of 62 patients with systemic vasculitis complicated by Pneumocystis jirovecii pneumonia (PJP) showed those with MPA had a higher mortality risk, possibly due to a higher prevalence of… https://t.co/yWjWOXtMwR https://t.co/2aD3EIsi7z
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Upcoming at #ACR2024 -- New updated Lupus Nephritis management Guidelines. Look for it! https://t.co/i5MbtBHhAb https://t.co/udm2YHYlRi
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FDA has approved Otulfi (ustekinumab-aauz), a ustekinumab biosimilar for the treatment of Crohn’s disease, ulcerative colitis, moderate to severe plaque psoriasis and active psoriatic arthritis. Otulfi ismade by Fresenius Kabi and Formycon https://t.co/p2h9X0C16W https://t.co/YD0uJSEbaq
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JAMA metaanalysis of psoriasis pts (40 RCTs, 21 438 pts) Rx w/ biologics: a >=90% PASI (skin) response was less likely with older age, prior biologics, higher BMI, and smoking https://t.co/v5EpOpYVYt https://t.co/wXTXP76Emu
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Hand-Held Imaging Could Transform Arthritis Care
A new hand-held scanner developed by UCL researchers can generate highly detailed 3D photoacoustic images in just seconds, paving the way for their use in a clinical setting for the first time and offering the potential for… https://t.co/YSCfoWCXpr https://t.co/du6cruFfRQ
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VASCULTIS Literature analysis shows most frequent citations, research centers and reveals the top 3 vasculitis topics to be:
1. Immune checkpoint inhibitors
2. GPA/Wegener's granulomatosis
3. SLE - lupus vasculopathy
https://t.co/FS2cuv9gt4 https://t.co/ziI4sfexrm
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Using MRI to Evaluate Knee Pain
Interim results from a randomized trial show that middle-aged patients with knee pain and suspected meniscal tears can benefit from MRI scans even in relatively simple cases.
https://t.co/xAVA07LcqD https://t.co/YRrZgiMQjs
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