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Open label trial compared arthroscopic repair to PT in 100 young pts w/ traumatic, MRI proven meniscal tear without knee OA. Outcomes at 24 months - both groups improvved and were not different between groups https://t.co/rbrUAWuKRa https://t.co/OaNTssAvCG
Links:
Dr. John Cush RheumNow ( View Tweet)
How much does diet and exercise help in knee osteoarthritis?
Pragmatic RCT (WE-CAN), n=823
a diet & exercise intervention program led to:
- 10kg weight loss
- some significant pain improvements
We need to fund diet & exercise programs for OA patients!
ABST1675 #ACR22 @RheumNow https://t.co/Ctm8ZoRF3o
David Liew drdavidliew ( View Tweet)
WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity:
💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL
🍽️+🚶♀️in OA? = Yes we can!
#ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC
sheila RHEUMarampa ( View Tweet)
Ab1675 #ACR22 WE-CAN - Knee OA
823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E)
Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO)
20% more likely: clinically meaningful improve
Improved BMI, 6MW, HRQoL, activity
Pain Rx, depression: no change
@RheumNow https://t.co/Su2g4Z38FV
Eric Dein ericdeinmd ( View Tweet)
Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl
Janet Pope Janetbirdope ( View Tweet)
Plenary session III:
Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life.
Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV
Robert B Chao, MD doctorRBC ( View Tweet)
Messier et al. WE-CAN pragmatic trial of diet and exercise (vs attention control) in knee OA with high BMI. Significant improvement in pain, walk distance, SF-36 with corresponding reduction in body weight @RheumNow #ACR22 Abstr#1675 https://t.co/uSSzx4u2sp https://t.co/upnIVecRjv
Richard Conway RichardPAConway ( View Tweet)
In overweight and obese patients with knee OA, 18-months of diet and exercise delivered in community settings significantly reduced WOMAC knee pain (-0.6) compared to an attention control group. Messier S Abs#1675 https://t.co/GvPCGz0NMN #ACR22 @RheumNow https://t.co/yWAwGwunzT
Dr. Antoni Chan synovialjoints ( View Tweet)
Promising data on denosumab in erosive OA
Phase 2 study - less erosive progression, more symptom improvement
Abs# L05 @RheumNow #ACR22 https://t.co/9Fg3r02ZQG
Robert B Chao, MD doctorRBC ( View Tweet)
Wittoek et al. 48-week RCT of Denosumab in erosive hand OA. Prevents structural progression! @RheumNow #ACR22 Abstr#L05 #ACRbest https://t.co/CI6VBERSmn https://t.co/OszJkGeJF7
Richard Conway RichardPAConway ( View Tweet)
L05 #ACR22 High-dose Denosumab in Erosive Hand OA
48Wk, Double-blind PBO Phase 2 100 patients
GUSS change higher in DEN v PBO at w24, incr at w48
New erosions lower in DEN w48 (2% v 7%, OR 0.23, p<0.001)
Open label extension w improvement to baseline
@RheumNow https://t.co/X6MF9q2bKj
Eric Dein ericdeinmd ( View Tweet)
Walrabenstein et al. RCT of 16-week triple intervention - plant-based diet, exercise, stress management - vs usual care in OA. It works, but we don't know which component, or if Hawthorn effect @RheumNow #ACR22 Abstr#1644 https://t.co/p74Ptd8bZ2 https://t.co/EOg7RxRmO7
Richard Conway RichardPAConway ( View Tweet)
Denosumab in erosive hand OA. 12-weekly dosing, primary end-point at 24 weeks.
@RheumNow #ACR22 #LateBreaking
Julian Segan JulianSegan ( View Tweet)
Yazici et al. IA Lorecivivint in Knee OA. 56 week DB-RCT of single injection at time 0. Didn't work. Not for primary endpoint (Pain NRS) or any PRO. @RheumNow #ACR22 Abstr#1639 https://t.co/66KyJW1zVz
Richard Conway RichardPAConway ( View Tweet)
Utamawatin et al. DB-RCT of Triamcinolone 10mg vs 40mg for knee OA. No difference! Wonder if 10mg would be better than saline? @RheumNow #ACR22 Abstr#1890 https://t.co/vcKze7mSf4 https://t.co/ErEkmUN0Wp
Richard Conway RichardPAConway ( View Tweet)
Maksymowych et al. RCT ofAdalimumab for knee OA!? it doesn't work. @RheumNow #ACR22 Abstr#1891 https://t.co/pfPVJ9A1Ex https://t.co/X7sLEaqGvT
Richard Conway RichardPAConway ( View Tweet)
Yazici et al. RCT of IA Lorecivivint for moderate/severe knee OA. CLK/DYRK inhibitor. No effect seen. @RheumNow #ACR22 Abstr#1899 https://t.co/XGQrMmNnSR https://t.co/rSJrT6Hms6
Richard Conway RichardPAConway ( View Tweet)
Bihlet et al. Anti-histamines may reduce structural progression of knee OA. Post-hoc analysis of 2 trials @RheumNow #ACR22 Abstr#1893 https://t.co/RrrelHDz75 https://t.co/Sf7RpjjAaN
Richard Conway RichardPAConway ( View Tweet)
Shanahan et al. RCT of Genicular nerve block for knee OA. It works but temporary, with loss of effect by week 12. @RheumNow #ACR22 Abstr#1892 https://t.co/VySjBGrVeR https://t.co/JNKQeOVB6z
Richard Conway RichardPAConway ( View Tweet)
Ab0577 #ACR22 Sao Paulo Aging & Health (SPAH)
Radius 1/3 BMD enhance fx risk estimates when combined w/ spine (RR 1.4, p=0.03)
For radius+hip or radius+spine/hip, radius DEXA is non-significant - only hip predicted fx
Use radius BMD when hip unattainable- THA/severe OA
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
