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Dr. John Cush RheumNow ( View Tweet)
Interestng overview/read on the Inflammasome - its history, clinical targeting and new inflammasome (NLRP3) inhibitors in development by pharma. https://t.co/DEdP09GZd7
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Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)
Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.
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Rheumatic Patients Are at Risk for COVID Death
Patients with rheumatic diseases who developed COVID-19 were at increased likelihood of death, with risk factors similar to those seen in the general population but also because of factors specific to their underlying disease and its treatment, analysis of data from an international registry foun
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French review of 41 TRAPS pts w/ amyloidosis AA. AA dx preceded TRAPS in 96% of cases, 47% needed renal replacement therapy and 14% died at 23 most F/U. 19 pts took biologics, 10 improved, 7 stabilized, 4 worsened. AA pts should be screened for TRAPS https://t.co/tONNSRCoOU
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Dr. John Cush RheumNow ( View Tweet)
122 Adult onset Still's disease pts followed a median of 12 mos shows 21% with >=1 relapses. The cumulative relapse rate was 29% at 36 mos. Relapses increased w intensive Rx (OR 6.8) & MAS (OR 4.0)."Intensive" refers to steroids plus DMARDs - not biologics https://t.co/BRKi5sUQQZ
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic: PFAPA Syndrome Recurrent Fevers, Stomatitis, Lymphadenopathy ? https://t.co/uMBk8e2wJO https://t.co/02ZMjRmOuU
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QD Clinic - PFAPA Syndrome Recurrent Fevers, Stomatitis, Lymphadenopathy ? https://t.co/uMBk8e2wJO https://t.co/LIs02svEDB
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Dr. Shenoi Suspect autoinflammatory Dz: patterned fevers MSK and skin involvement Serositis Other - aphthous ulcers, CNS (stroke, basal ganglia calcification,) ILD, LN, lipodystrophy) ethnicity (FMF or Mediterranean) Family Hx -- Testing options! #RWCS2021 @RheumNow @RWCSmtg https://t.co/DZk4hsxbk4
Dr. Shenoi reviews PFAPA (Periodic Fever, Aphthous ulcers, Pharyngitis, and Adenitis) in children and adults - and the potential for associated genes/ Bechet's disease spectrum. #RWCS2021 #RWCS @RWCSmtg @RheumNow https://t.co/AS4qVqUsFY
PFAPA does not have a genetic dx (yet). But she's sure increase in IL - 12 p70, this making apremilast and ustekinumab potential therapy for difficult cases. @RWCSmtg https://t.co/gdz7d5KCrm
PFAPA may be part of a spectrum the includes Behcets @rwcs https://t.co/wmX76bFPX2
PFAPA (aka Marshall syndrome) also occurs in adults @RWCSmtg https://t.co/52NVpKGCzP
Dr. Susan Shenoy @rwcs shows discovery of autoinflammatory diseases began w MEFV genes (FMF) in 1997, followed by genes for TRAPS and HIDS in 1999. @ https://t.co/sG4BlK1zhR