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Respiratory and Cardiovascular Mortality Higher in RA Women
Using data from the Nurses' Health Study (NHS), Sparks and colleagues analyzed 119,209 women beginning in 1976. The identified 964 incident RA cases and 28,808 deaths during 36 years of prospective follow-up.
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Diet, Exercise and Glucosamine Fail to Prevent Knee Osteoarthritis
Primary prevention of osteoarthritis is an ideal goal for which there has been little success in clinical trials.
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Infertility in Rheumatoid Arthritis Linked to Disease Activity
Women with rheumatoid arthritis are said to have a normal number of pregnancies. However, most of these are conceived prior to the onset of RA. Once diagnosed, the RA patient who wishes to become pregnant may be faced with difficult medication choices if she is planning to become pregnant.
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Is DLCO Predictive in Rheumatoid Interstitial Lung Disease?
Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Its presence may portend grave outcomes for those affected. The prevalence of ILD in RA ranges from 7.7% to 44% depending on the assessment tools used.
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Optimizing Treat-to-Target in RA
Treat-to-target is a common management strategy for rheumatoid arthritis that aims to employ the strategy most effective in terms of achievement of optimal therapeutic outcomes in RA.
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Hip Fractures Increased in Rheumatoid Arthritis
An analysis of 741,589 patients over age 45 years from southern Swedish registry examined patients who were followed (between 1998 and 2012) until a hip fracture, death or exit from the region occurred.
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High Sodium Intake Linked to Risk of RA
Diet has long been considered a potential risk factor for the onset or pathogenesis of rheumatoid arthris. Obesity and the microbiome are being intensively studied as risk factors for RA.
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Rheumatoid Arthritis Associated with More Severe Acute Coronary Syndromes and Outcomes
Acute coronary syndromes (ACSs), myocardial infarctions and heart failure appear to be a hazardous consequence to systemic and articular inflammation in rheumatoid arthritis.
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Dr. Woodcock Gives Senate FDA Update on Biosimilars
Biologics have been a great advance in therapeutics, but at great cost. Although biologics account for less than 1% of all prescriptions in the USA, they account for 28% percent of the cost of prescribed medications.
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Increasing Numbers of Knee Replacements
Knee replacement surgery is on the rise, and so is the cost.
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Biosimilar SB4 Performs Equally to Etanercept
Biosimilars are rapidly growing. Many of these will have their first introduction to countries outside of the USA. There is concern whether biosimilars will provide identical pharmacodynamics, biological function, efficacy and toxicity to reference products, both in the short and long term.
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DATA-Switch Study Finds the Right Sequence to Building Better Bone Mass
Long-term management of osteoporosis can be challenging, and given the increasing number of choices, the best sequence of drug use has not been addressed adequately.
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DAS28-CRP or DAS28-ESR: Are they Biosimilar?
The disease activity score (DAS28) has been developed as a dynamic assessment tool and a therapeutic response measure for use in clinical trials and practice.
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Diastolic Dysfunction in Rheumatoid Arthritis
Poor cardiovascular outcomes have been linked to inflammation and rheumatoid arthritis (RA). This includes higher rates of MI and heart failure (HF).
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Gout: New Classification Criteria from ACR/EULAR
The American College of Rheumatology and the European League against Rheumatism joined forces to finalize classification criteria for gout, a condition that affects 8.3 million Americans.
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A Controlled Trial of Yoga Benefits Arthritis Patients
Yoga and stretching appear to be important forms of exercise for patients with fibromyalgia, but their utility has seldom been explored in patients with rheumatoid or osteoarthritis.
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Monitoring of Novel Therapies in Rheumatology
The rheumatology therapeutic landscape has changed almost yearly in the last 15 years, with the introduction of at least 16 biologic or novel agents for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), spondyloarthritis (SpA), juvenile arthritis,
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FDA Warns of Bone Fracture Risk and Lower BMD with Diabetes Drug
The FDA has strengthened its warnings for the type 2 diabetes drug canagliflozin (Invokana, Invokamet) and the apparent increased risk of bone fractures, and added new information about decreased bone mineral density.
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Antibodies to 14-3-3η Found in Large Vessel Vasculitis
14-3-3η (eta) is a new test that may be useful in diagnosing patients with early rheumatoid arthritis. The test is 77% sensitive and 93% specific for RA and developers have found that antibodies against 14-3-3η may correlate with drug responsiveness.
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Arthritis and Poverty: Chicken or Egg?
The development of arthritis is an underappreciated reason why individuals become impoverished -- a finding that was particularly pronounced for women, an Australian study found.
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