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RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.

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RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Jack Cush, MD

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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RheumNow Podcast – Pounds of Prevention (3.5.2021)

Jack Cush, MD

Dr. Jack Cush reviews and discusses nearly a dozen news reports and journal articles from the past week on RheumNow.com.

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Weight Loss to Avert Risk of Gout

Jack Cush, MD

Analysis of the NHANES population survey data shows weight gain during adulthood increases the risk of gout and that maintaining normal weight could reduce the overall gout risk by nearly 33%.

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Combo Therapy Boosts Response in Uncontrolled Gout

MedPage Today

The addition of an immunomodulating agent to pegloticase (Krystexxa) among patients with uncontrolled gout significantly improved response rates, a systematic literature review found.

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ANAGO Study - Anakinra for Gout Flare

MedPage Today

The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found.

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Are You a Super Rheum? https://t.co/omvQXwhcoV https://t.co/8iQaRAi5di

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Dr. Ken Saag giving Rheum Grand Rounds at UT Southwestern. Data showing lower dose colchicine is safer than higher dose in acute gout @UTSWIMchief @KenSaag https://t.co/5KAn9SWlrU
Dr. John Cush RheumNow ( View Tweet)
News Feature: RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout https://t.co/3TkjwlrSEP https://t.co/GaS8cAJijq

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Dr. John Cush RheumNow ( View Tweet)
News Feature: Are You a Super Rheum? https://t.co/LsGpFNXlkp https://t.co/Q9iojEQNqL

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Dr. John Cush RheumNow ( View Tweet)
Top 4 arthritis types that significantly increase the risk of CVA: 1) RA (RR=1.38), 2) ankylosing spondylitis (RR=1.49), 3) psoriatic arthritis (RR=1.33) & gout (RR=1.4). With these, the risk was higher in younger (<45 yrs) (RR = 1.46), not older (>65) https://t.co/Snb6OrtZJH

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Dr. John Cush RheumNow ( View Tweet)

Septic arthritis MIMICs (all presenting as acute monoarthritis) - consider: cellulitis, bursitis, abscess, osteonecrosis, gout, pseudogout, Lyme, Osteomyelitis, reactive arthritis, Lyme disease,, Rheumatoid arthritis, & Transient synovitis (kids) https://t.co/uNirAcoBds

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Dr. John Cush RheumNow ( View Tweet)

Great Gout Teaching points. Here's my 2 cards on how to Stop #Gout https://t.co/bJ4D4Qzd5N https://t.co/ZUX0TXm1Rn

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Dr. John Cush RheumNow ( View Tweet)
News Feature: Weight Loss to Avert Risk of Gout https://t.co/wzf69PvSJc https://t.co/Dph4OAC2Ar

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Dr. John Cush RheumNow ( View Tweet)
Comparison of MSU crystal ID, DECT scanning and US to Dx gout - study of 147 pts. Compared to the gold standard (MSU ID), Feet/ankles (87% sensitivity; 100% specificity) or knees DECT (91% & 87%) alone had best Dx accuracy. US was inferior to DECT. https://t.co/h8ctkfeadZ

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Combo Therapy Boosts Response in Uncontrolled Gout https://t.co/K6tmYWqDCg https://t.co/Li9fcLnP4f

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Dr. John Cush RheumNow ( View Tweet)
We are three weeks out from RheumNow Live. Are you planning on attending? https://t.co/vJlU0Z3Q3x

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Dr. John Cush RheumNow ( View Tweet)

News Feature: ANAGO Study - Anakinra for Gout Flare https://t.co/btP7ivMuPO https://t.co/HHsUKsjjuI

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Dr. John Cush RheumNow ( View Tweet)
SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu

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Dr. John Cush RheumNow ( View Tweet)
MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout. https://t.co/DRkIMOAhs4 https://t.co/2dft1QjC6E

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Dr. John Cush RheumNow ( View Tweet)
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